IMR Press / FBL / Volume 13 / Issue 11 / DOI: 10.2741/3012

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair
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1 Department of Molecular Biology and Biochemistry, University of California, Irvine 92697-3900
2 Sue and Bill Gross Stem Cell Research Center University of California, Irvine 92697-3900
3 Center for Immunology, University of California, Irvine 92697- 3900

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Landmark Ed) 2008, 13(11), 4393–4406; https://doi.org/10.2741/3012
Published: 1 May 2008
Abstract

Viral infection of the central nervous system (CNS) results in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences. One of the principal factors that directs the outcome of infection is the localized innate immune response, which is proceeded by the adaptive immune response against the invading viral pathogen. The role of the immune system is to contain and control the spread of virus within the CNS, and paradoxically, this response may also be pathological. Studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV) have provided important insights into how the immune system combats neuroinvasive viruses, and have identified molecular and cellular mechanisms contributing to chronic disease in persistently infected mice.

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