Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review

MASAHIRO SAKATA; AKINOBU TAKAKI; ATSUSHI OYAMA; TAKUYA ADACHI; NOZOMU WADA; YASUTO TAKEUCHI; TETSUYA YASUNAKA; HIDEKI ONISHI; HIDENORI SHIRAHA; HIROYUKI OKADA

doi:10.2739/kurumemedj.MS6723011

Case Report

Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review

MASAHIRO SAKATA, AKINOBU TAKAKI, ATSUSHI OYAMA, TAKUYA ADACHI, NOZOMU WADA, YASUTO TAKEUCHI, TETSUYA YASUNAKA, HIDEKI ONISHI, HIDENORI SHIRAHA, HIROYUKI OKADA

Author information

MASAHIRO SAKATA
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
AKINOBU TAKAKI
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ATSUSHI OYAMA
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
TAKUYA ADACHI
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
NOZOMU WADA
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
YASUTO TAKEUCHI
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
TETSUYA YASUNAKA
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
HIDEKI ONISHI
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
HIDENORI SHIRAHA
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
HIROYUKI OKADA
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Keywords: anorexia nervosa, hepatic complication, starvation induced liver injury, refeeding syndrome

JOURNAL FREE ACCESS

2020 Volume 67 Issue 2.3 Pages 121-129

DOI https://doi.org/10.2739/kurumemedj.MS6723011

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Abstract

Summary: Anorexia nervosa (AN) can cause severe protein energy malnutrition and the consequent development of various organ disorders. AN is known to cause hepatic complications. We report two cases of starvation and refeeding-induced liver injury in patients with AN, and review the literature on the hepatic complications of AN. Acute liver injury can be induced by both starvation and refeeding, although the underlying pathomechanisms and management of liver injury differ between these two conditions. Clinicians should carefully identify the clinical features to ensure an accurate diagnosis and appropriate management of these conditions.

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