EVALUATION OF SOME ELEMENT AND MINERAL LEVELS IN PRESCRIPTION AND NON-PRESCRIPTION DOG DIETS
DOI:
https://doi.org/10.26873/SVR-1726-2023Keywords:
elements, minerals, dog, food, prescriptionAbstract
Various prescription diets prescribed by veterinarians for specific diseases in dogs have been developed and introduced to the market. Trace element and mineral levels, which are essential for healthy living conditions in animals, can differ in both prescription and non-prescription foods. In our study, it was aimed to determine the levels of some elements and minerals in various prescription and non-prescription dry foods used in dog nutrition and to evaluate their therapeutic importance.
In the study, a total of 100 different prescription dry food formulated for hepatic diseases (H, n=25), renal diseases (R, n=25), gastrointestinal diseases (GI, n=25) and, allergic diseases (HA, n=25) were used. Non-prescription dry foods from different flavors and brands in the market were considered as the control group (C, n=50). Copper (Cu), Iron (Fe), Manganese (Mn), Zinc (Zn), Selenium (Se), Calcium (Ca), and Phosphorus (P) levels of all dry foods were analyzed by Inductively Coupled Plasma-Optical Emission Spectrometer (ICP-OES, Thermo iCAP 6000 series) and the results were compared between groups. Statistical analysis was evaluated using SPSS 21.
Cu levels in GI and HA groups were higher than in the control group (p<0.05 and p<0.01, respectively). Fe levels were higher in the GI group and lower in the HA group than in the control group (p<0.05). Mn level was significantly higher in the H group compared to the control group (p<0.001). The Mn levels in GI and HA groups were higher than the control group (p<0.01). There was no statistical difference in Se and Zn levels between prescription and non-prescription dry foods. Ca and P levels in all groups were statistically lower than in the control group (p<0.001).
There are significant differences in element and mineral levels in prescription and non-prescription dry foods. These values may be out of the legal limits determined by EU Regulation. Considering the therapeutic purpose of these prescription formulas, some element and mineral amounts were determined as inappropriate.
Vrednotenje vsebnosti nekaterih elementov in mineralov v predpisani in nepredpisani prehrani za pse
Izvleček: Na trgu so prisotne različne diete na recept, ki jih veterinarji predpisujejo za določene bolezni psov. Vsebnost elementov v sledovih in mineralov, ki so bistveni za zdravo življenje živali, se lahko razlikuje tako v hrani na recept kot v hrani brez recepta. V naši študiji smo želeli določiti vsebnost nekaterih elementov in mineralov v različnih predpisanih in nepredpisanih suhih vrstah hrane za pse, ter oceniti njihov terapevtski pomen.
V študiji je bilo uporabljenih 100 različnih vrst suhe hrane, formulirane za jetrne bolezni (H, n=25), ledvične bolezni (R, n=25), bolezni prebavil (GI, n=25) in alergijske bolezni (HA, n=25). Suha hrana brez recepta različnih okusov in blagovnih znamk na trgu je bila obravnavana kot kontrolna skupina (C, n=50). Vsebnost bakra (Cu), železa (Fe), mangana (Mn), cinka (Zn), selena (Se), kalcija (Ca) in fosforja (P) v vseh vrstah suhe hrane smo analizirali z optično emisijsko spektroskopijo z induktivno sklopljeno plazmo (ICP-OES, serija Thermo iCAP 6000) in rezultate primerjali med skupinami. Statistična analiza je bila narejena v programu SPSS 21.
Vsebnost Cu v skupinah GI in HA je bila višja kot v kontrolni skupini (p<0,05 oziroma p<0,01). Vsebnost Fe je bila višja v skupini GI in nižja v skupini HA kot v kontrolni skupini (p<0,05). Raven Mn je bila bistveno višja v skupini H v primerjavi s kontrolno skupino (p<0,001). Ravni Mn v skupinah GI in HA so bile višje kot v kontrolni skupini (p<0,01). Med suho hrano na recept in suho hrano brez recepta ni bilo statistične razlike v vsebnosti Se in Zn. Vsebnosti Ca in P so bile v vseh skupinah statistično značilno nižje kot v kontrolni skupini (p<0,001).
Vsebnost elementov in mineralov v suhi hrani na recept in suhi hrani brez recepta se je bistveno razlikovala. Te vrednosti so lahko izven zakonsko določenih mejnih vrednosti, ki jih določa uredba EU. Glede na terapevtski namen diete na recept smo nekatere količine elementov in mineralov določili kot neustrezne.
Ključne besede: elementi; minerali; pes; hrana; recept
References
● 1. FEDIAF EuropeanPetFood. Annual Report 2023 [online]. Bruxelles: Fediaf, 2023. https://europeanpetfood.org/about/annual-report (18. 8. 2023)
● 2. Zicker SC. Evaluating pet foods: how confident are you when you recommend a commercial pet food? Top Companion Anim Med 2008; 23: 121–6. DOI: https://doi.org/10.1053/j.tcam.2008.04.003
● 3. Kelly RE. Feeding the modern dog: an examination of the history of the commercial dog food industry and popular perceptions of canine dietary patterns. Michigan: Michigan State University, 2012.
● 4. Seaman R, Bartges JW. Canine struvite urolithiasis. Compend Contin Educ Vet 2001; 23: 407–20.
● 5. Honeckman A. Current concepts in the treatment of canine chronic hepatitis. Clin Tech Small Anim Pract 2003; 18: 239–44. DOI: https://doi.org/10.1016/S1096-2867(03)00050-1
● 6. Kato M, Miyaji K, Ohtani N, Ohta M. Effects of prescription diet on dealing with stressful situations and performance of anxiety-related behaviors in privately owned anxious dogs. J Vet Behav 2012; 7: 21–6. DOI: https://doi.org/10.1016/j.jveb.2011.05.025
● 7. Kerl ME, Johnson PA. Nutritional plan: matching diet to disease. Clin Tech Small Anim Pract 2004; 19: 9–21. DOI: https://doi.org/10.1053/S1096-2867(03)00081-1
● 8. Olivry T, DeBoer DJ, Favrot C, et al. Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis. Vet Dermatol 2010; 21: 233–48. DOI: https://doi.org/10.1111/j.1365-3164.2010.00889.x
● 9. Roudebush P, Schick RO. Evalution of a commerical canned lamb and rice diet for the management of adverse reactions to food in dogs. Vet Dermatol 1994; 5: 63–7. DOI: https://doi.org/10.1111/j.1365-3164.1994.tb00013.x
● 10. Yamka RM, Friesen KG, Frantz NS. Identification of canine markers related to obesity and the effects of weight loss on the markers of interest. Intern J Appl Res Vet Med 2006; 4: 282–92.
● 11. Kaya S. Biyoelementler. In: Burçak G, ed. Biyokimya Ders Kitabı. İstanbul: İstanbul Cerrahpaşa Tıp Üniversitesi, 2012.
● 12. Choong YY, Norli I, Abdullah AZ, Yhaya MF. Impacts of trace element supplementation on the performance of anaerobic digestion process: a critical review. Bioresour Technol 2016; 209: 369–79. DOI: https://doi.org/10.1016/j.biortech.2016.03.028
● 13. Grotto D, Carneiro MFH, De Castro MM, Garcia SC, Junior FB. Long-term excessive selenium supplementation induces hypertension in rats. Biol Trace Elem Res 2018; 182: 70–7. DOI: https://doi.org/10.1007/s12011-017-1076-1
● 14. Özçelik D, Toplan S, Özdemir S, Akyolcu MC. Effects of excessive copper intake on hematological and hemorheological parameters. Biol Trace Elem Res 2002; 89: 35–42. DOI: https://doi.org/10.1385/BTER:89:1:35
● 15. Wang Y, Jiang L, Li Y, Luo X, He J. Excessive selenium supplementation induced oxidative stress and endoplasmic reticulum stress in chicken spleen. Biol Trace Elem Res 2016; 172: 481–7. DOI: https://doi.org/10.1007/s12011-015-0596-9
● 16. Gurnee CM, Drobatz KJ. Zinc intoxication in dogs: 19 cases (1991–2003). J Am Vet Med Assoc 2007; 230: 1174–9. DOI: https://doi.org/10.2460/javma.230.8.1174
● 17. Seguin MA, Bunch SE. Iatrogenic copper deficiency associated with long-term copper chelation for treatment of copper storage disease in a Bedlington Terrier. J Am Vet Med Assoc 2001; 218: 1593–7. DOI: https://doi.org/10.2460/javma.2001.218.1593
● 18. Kather S, Grützner N, Kook PH, Dengler F, Heilmann RM. Review of cobalamin status and disorders of cobalamin metabolism in dogs. J Vet Intern Med 2020; 34: 13–28. DOI: https://doi.org/10.1111/jvim.15638
● 19. Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagn Invest 2000; 12: 101–10. DOI: https://doi.org/10.1177/104063870001200201
● 20. Meertens NM, Bokhove CAM, Van Den Ingh TSGAM. Copper-associated chronic hepatitis and cirrhosis in a european shorthair cat. Vet Pathol 2005; 42: 97–100. DOI: https://doi.org/10.1354/vp.42-1-97
● 21. Fieten H, Hooijer-Nouwens BD, Biourge VC, et al. Association of dietary copper and zinc levels with hepatic copper and zinc concentration in Labrador Retrievers. J Vet Intern Med 2012; 26: 1274–80. DOI: https://doi.org/10.1111/j.1939-1676.2012.01001.x
● 22. Haynes JS, Wade PR. Hepatopathy associated with excessive hepatic copper in a Siamese cat. Vet Pathol 1995; 32: 427–9. DOI: https://doi.org/10.1177/030098589503200414
● 23. Panda D, Patra RC, Nandi S, Swarup D. Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection. Res Vet Sci 2009; 86: 36–42. DOI: https://doi.org/10.1016/j.rvsc.2008.05.008
● 24. Elsayed NM, Kubesy AA, Salem NY. Altered blood oxidative stress biomarkers in association with canine parvovirus enteritis. Comp Clin Pathol 2020; 29: 355–9. DOI: https://doi.org/10.1007/s00580-019-03067-x
● 25. Fage SW, Faurschou A, Thyssen JP. Copper hypersensitivity. Contact dermatitis 2014; 71: 191–201. DOI: https://doi.org/10.1111/cod.12273
● 26. Hostynek JJ, Maibach HI. Copper Hypersensitivity: dermatologic aspects – an overview. Rev Environ Health 2003; 18: 153–83. DOI: https://doi.org/10.1515/REVEH.2003.18.3.153
● 27. Vural H, Uzun K, Uz E, Koçyigit A, Akyol O. Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma. J Trace Elem Med Biol 2000; 14: 88–91. DOI: https://doi.org/10.1016/S0946-672X(00)80036-X
● 28. McCown JL, Specht AJ. Iron homeostasis and disorders in dogs and cats: a review. J Am Anim Hosp Assoc 2011; 47: 151–60. DOI: https://doi.org/10.5326/JAAHA-MS-5553
● 29. AAFCO. AAFCO methods for substantiating nutritional adequacy of dog and cat foods [online]. Champaign: Association of American feed control officials, 2023.https://www.aafco.org/wp-content/uploads/2023/01/Model_Bills_and_Regulations_Agenda_Midyear_2015_Final_Attachment_A.__Proposed_revisions_to_AAFCO_Nutrient_Profiles_PFC_Final_070214.pdf
● 30. Whittemore JC, Newkirk KM, Reel DM, Reed A. Hepatic copper and iron accumulation and histologic findings in 104 feline liver biopsies. J Vet Diagn Invest 2012; 24: 656–61. DOI: https://doi.org/10.1177/1040638712445765
● 31. Shaheen SO, Newson RB, Henderson AJ, et al. Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema. Eur Respir J 2004; 24: 292–7. DOI: https://doi.org/10.1183/09031936.04.00117803
● 32. David TJ, Wells FF, Sharpe TC, Gibbs AC, Devlin J. Serum levels of trace metals in children with atopic eczema. Br J Dermatol 1990; 122: 485–9. DOI: https://doi.org/10.1111/j.1365-2133.1990.tb14725.x
● 33. Drury KE, Schaeffer M, Silverberg JI. Association between atopic disease and anemia in US children. JAMA Pediatr 2016; 170: 29–34. DOI: https://doi.org/10.1001/jamapediatrics.2015.3065
● 34. Glow AG, Marques AIC, Yool DA, Duncan A, Mellanby RJ. Whole blood manganese concentrations in dogs with congenital portosystemic shunts. J Vet Intern Med 2010; 24: 90–6. DOI: https://doi.org/10.1111/j.1939-1676.2009.0408.x
● 35. Norton RD, Lenox CE, Manino P, Vulgamott JC. Nutritional considerations for dogs and cats with liver disease. J Am Anim Hosp Assoc 2016; 52: 1–7. DOI: https://doi.org/10.5326/JAAHA-MS-6292R2
● 36. Gandhi D, Rudrashetti AP, Rajasekaran S. The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions. J Appl Toxicol 2022; 42:103–29. DOI: https://doi.org/10.1002/jat.4214
● 37. Valenta R, Mittermann I, Werfel T, Garn H, Renz H. Linking allergy to autoimmune disease. Trends Immunol 2009; 30: 109–16. DOI: https://doi.org/10.1016/j.it.2008.12.004
● 38. Watchmaker J, Collins R, Chaney K. Allergic contact dermatitis to manganese in metallic implant. Dermatitis 2015; 26: 149–50. DOI: https://doi.org/10.1097/DER.0000000000000117
● 39. Booles D, Burger IH, Whyte AL, Anderson RS, Carlos GM, Robinson IP. Effects of two levels of zinc intake on growth and trace element status in labrador puppies. J Nutr 1991; 121(suppl. 11): S79–80. DOI: https://doi.org/10.1093/jn/121.suppl_11.S79
● 40. Cummings JE, Kovacic JP. The ubiquitous role of zinc in health and disease. J Vet Emerg Crit Care 2009; 19: 215–40. DOI: https://doi.org/10.1111/j.1476-4431.2009.00418.x
● 41. Lowe JA, Wiseman J, Cole DJA. Zinc source influences zinc retention in hair and hair growth in the dog. J Nutr 1994; 124(suppl. 12): S2575–6. DOI: https://doi.org/10.1093/jn/124.suppl_12.2575S
● 42. Or ME, Bakırel U, Tuncel H, et al. Deri hastalıklı köpeklerde serum cinko ve bakır Düzeyleri ile histopatolojik değişikliklerin ilişkisi. Istanbul Üniv Vet Fak Derg 2002; 28: 337–45.
● 43. Zentrichová V, Pechová A, Kovaříková S. Selenium and dogs: a systematic review. Animals 2011; 11: e418. doi:10.3390/ani11020418. DOI: https://doi.org/10.3390/ani11020418
● 44. Sharada KC, Purushotha B, Radhakrish PM, Mantri AP, Vagdevi HM . Role of selenium in pets health and nutrition: a review. Asian J Anim. Sci 2011; 5: 64–70. DOI: https://doi.org/10.3923/ajas.2011.64.70
● 45. Zachara BA, Pawluk H, Korenkiewicz J, Skok Z. Selenium levels in kidney, liver and heart of newborns and infants. Early Hum. Dev 2001; 63: 103–11. DOI: https://doi.org/10.1016/S0378-3782(01)00141-4
● 46. Aaseth J, Alexander J, Alehagen U, et al. The aging kidney-as influenced by heavy metal exposure and selenium supplementation. Biomolecules 2021; 11: e1078. doi:10.3390/biom11081078. DOI: https://doi.org/10.3390/biom11081078
● 47. Xie C, Zeng M, Shi Z, Li S, Jiang K, Zhao Y. Association between selenium status and chronic kidney disease in middle-aged and older Chinese based on CHNS data. Nutrients 2022; 14: e2695. doi:10.3390/nu14132695. DOI: https://doi.org/10.3390/nu14132695
● 48. Stockman J, Villaverde C, Corbee RJ. Calcium, phosphorus, and vitamin D in dogs and cats: beyond the bones. Vet Clin North Small Anim Pract 2021; 51: 623–34. DOI: https://doi.org/10.1016/j.cvsm.2021.01.003
● 49. Parker VJ. Nutritional management for dogs and cats with chronic kidney disease. Vet Clin North Small Anim Pract 2021; 51: 685–710. DOI: https://doi.org/10.1016/j.cvsm.2021.01.007
● 50. Davies M, Alborough R, Jones L, Davis C, Williams C, Gardner DS. Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines. Sci Rep 2017; 7: e17107. doi:10.1038/s41598-017-17159-7. DOI: https://doi.org/10.1038/s41598-017-17159-7
● 51. Duran A, Tuzen M, Soylak M. Trace element concentrations of some pet foods commercially available in Turkey. Food Chem Toxicol 2010; 48: 2833–7. DOI: https://doi.org/10.1016/j.fct.2010.07.014
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