New reagents for the spectrophotometric determination of ranitidine hydrochloride

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Published: Sep 30, 2010
DOI: https://doi.org/10.26850/1678-4618eqj.v35.3.2010.p109-115
Keywords:
spectrophotometry, ranitidine hydrochloride, ceric ammonium sulphate, malachite green, crystal violet

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Badiadka Narayana
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Karnataka, India.
https://orcid.org/0000-0001-8945-4516
Kunnummel Veena
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Karnataka, India.
Krishnamurthy Ashwani
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Karnataka, India.
Divya Narayana Shetty
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Karnataka, India.

Abstract

A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer’s law is obeyed in the concentration range of 0.4-8.0 μg/ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6μg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell’s sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms.

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How to Cite
Narayana, B., Veena, K., Ashwani, K., & Shetty, D. N. (2010). New reagents for the spectrophotometric determination of ranitidine hydrochloride. Eclética Química, 35(3), 109–115. https://doi.org/10.26850/1678-4618eqj.v35.3.2010.p109-115
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Vol. 35 No. 3 (2010): Eclética Química
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Original articles
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References

The Indian Pharmacopeia, The Controller of Publications, Ministry of Health and family Welfare, Govt. of India, New Delhi, 1996, pp.659.

R.N.Brogden, A.A. Carmine, R.C. Heel, T.M. Speight, G.S. Avery, Drugs 24 (1982) 267

W. Catterall, K. Mackie, Local anaesthetics. In J. G. Hardman & L.E. Limdind (Eds.), The pharmalogical basis of therapeutics (9th ed). Goodman and Gilman. Oxford, 1996, Pergamon Press

G. Tougas, D. Armstrong, Can. J.Gastroenterol 11 (1997) 51B

P. F. Carey, L.E. Matin, P.E. Owen, J. Chromatogr 225 (1981)161

L.E. Martin, J. Oxford, R.J.N. Yanner, Xenobiotica 11 (1981) 831

L.H. Overby, G.C. Carver, R.M. Philpot, Chem. Biol. Interact 106 (1997) 29

J.H.Kang, W.G. Chung, K.H.Lee, C.S. Park, J.S.Kang , I.C.Shin, H.K.Roh HK, M.S.Dong , H.M.Baek, Y.N.Cha Pharmacogenetics 10 (2000) 67

T. Ozden, A. Ungovmus, A. Tosun, S. Erasan, Spectroscop. Lett 30 (1997) 835

E. Dreassi, G. Ceramelli, P.Corti, P.L. Perruccio, S. Lonardi, Analyst 121 (1996) 219.

S. Fenwick, W.N. Jenner, P. Linacre, R.M. Rooney, S.A. Ring, Anal. Proc. 31(1994) 103.

[12] C. Lopez-Erroz, P.Vinas, N. Campillo, M.Hernandez-Cardoba, Analyst 121 (1996) 1043

P. Richter, M.I. Toral, F. Munoz-Varzas Analyst 119 (1994) 1371

A.Z.Abu-Zuhri, M. Hannoun, S.I.Al-Khalil, H. Hasan, Anal. Lett. 21 (1988) 1845.

P.S.Sankar, S.J.Reddy, Indian.J. Pharm. Sci 51 (1989) 263

M.A. Kelly, K.D.Altria, C.Grace, B.J.Clark, J.Chromatogr 798 (1996) 297

G. Bettermann, S. Cabrera, S. Heizenroeder, D. Lubda, Labor Praxis 22 (1998) 30

G.L. Iloyer, J. Le Doux, P.E. Nolan Jr, J. Liq. Chromatogr 18 (1995) 1239.

Z. Atkosar, M. Tunsel, Acta. Pharm. Turc 31 (1989)139

E.V.Rao, P.J.Rao, S.S.N. Murty, G.R.Rao Indian .J .Pharm Sci.49 (1987) 143

G.R. Rao, A.B.Avadhanulu, D.K.Vatsa DK, Indian Drugs 27 (1989) 133

Y. Ozsoy, B.Guvner, Acta. Pharm. Turc 29 (1987) 13

K.N. Raut, S.D. Sabnis. Indian. J. Pharm. Sci 49 (1987) 65

K. Basavaiah, B.C. Somashekar Ecl Quím 32 (2007) 19

K. Basavaiah, P.N.Gowda Indian .J .Chem. Technol 11 (2004) 11.

C.S.P. Sastry, S.G. Rao, J .S .V. M L Rao, P.Y. Naidu Anal. Lett 30 (1997) 2377

J. Ermer, J. Pharm. Biomed. Anal 24 (2001) 755