| About the author: |
F. G. Sadikhov |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to perform an immunohistochemical study of autoimmune changes in the thyroid gland in autoimmune thyroiditis patients who received various treatment methods. In the main group, immunohistochemical studies were performed on 30 patients. The control group consisted of six patients in whom the histochemical examination was performed postmortem. Statistically significant differences were found between the forms of autoimmune thyroiditis according to Ki–67(+) (F=1428.687, p<0.050). According to the specific amount of Ki–67(+), p53(+), and thyroglobulins, there is a statistical difference between forms of autoimmune thyroiditis in cells. A correct assessment of the proliferative activity of the thyroid gland tissue during immunohistochemical studies with the determination of biomarkers Ki–67(+), p53(+) and thyroglobulin may indicate the preservation of the apoptosis mechanism, which will allow to predict the risk of recurrence of the disease and the malignancy of nodular forms of autoimmune thyroiditis. |
| Tags |
autoimmune thyroiditis,thyroglobulin,proliferative activity,biomarker,immunohistochemical studies |
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| Publication of the article |
«World of Medicine and Biology» №2(84), 2023 year, 139-143 pages, index UDK 616.44–089 |
| DOI |
10.26724/2079-8334-2023-2-84-139-143 |
