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Food Science and Human Wellness 2024, 13(3): 1513-1530 https://doi.org/10.26599/FSHW.2022.9250128
Research Article | Open Access | Issue | Published: 08 February 2024

Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites

Show Author's Information Mingzhi Zhua,b,,  Bohao Shanga,  Fang Zhoua,  Yong Yuanc,  Feiyan Yinc,  Jin Caoc,  Jianan Huanga,  Kunbo Wanga,  Xin Zengb( ),  Maiquan Lid( ),  Zhonghua Liua( )
College of Horticulture, Hunan Agricultural University, Changsha 410128, China
College of Life Sciences, Huaibei Normal University, Huaibei 235000, China
Hunan Tea Group Co., Ltd., Changsha 410128, China
School of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China

Peer review under responsibility of Tsinghua University Press.

Keywords:
Gut microbiota, Obesity, Polysaccharides, Golden-f lower fungus, Aspergillus cristatus
Cite this article:
Zhu M, Shang B, Zhou F, et al. Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites. Food Science and Human Wellness, 2024, 13(3): 1513-1530. https://doi.org/10.26599/FSHW.2022.9250128
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Abstract Full text About this article

Golden-flower fungus, the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea, is considered a potential probiotic fungus based on its anti-obesity effect. However, the classif ication of golden-f lower fungi is still controversial; the anti-obesity effect of golden-f lower fungus polysaccharides remains unknown. In this study, we identify a golden-f lower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis, which resolves the controversy of classif ication. Moreover, we f ind A. cristatus polysaccharides (ACPS) attenuate obesity in rats. ACPS modulate gut bacterial composition, in which Akkermansia, Akkermansia muciniphila, Bacteroides, Romboutsia, Blautia, and Desulfovibrio are considered the core microbes regulated by ACPS.ACPS increase fecal total short-chain fatty acid content and serum, hepatic, and fecal total bile acid content. Furthermore, ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity, according to a fecal transplantation experiment. Thus, ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites.


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About this article

Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites

Show Author's information Mingzhi Zhua,b,, Bohao Shanga, Fang Zhoua, Yong Yuanc, Feiyan Yinc, Jin Caoc, Jianan Huanga, Kunbo Wanga, Xin Zengb( ), Maiquan Lid( ), Zhonghua Liua( )
College of Horticulture, Hunan Agricultural University, Changsha 410128, China
College of Life Sciences, Huaibei Normal University, Huaibei 235000, China
Hunan Tea Group Co., Ltd., Changsha 410128, China
School of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China

Peer review under responsibility of Tsinghua University Press.

Highlights

• Golden-flower fungus in Fu-brick tea was identified as Aspergillus cristatus.

• A. cristatus polysaccharides (ACPS) effectively attenuated obesity in rats.

• ACPS regulated short chain fatty acid and bile acid metabolism in gut.

• The anti-obesity of ACPS was attributed to the modulation on gut microbiota.

• ACPS might serve as a prebiotic to treat obesity and modulate gut microbiota.

Abstract

Golden-flower fungus, the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea, is considered a potential probiotic fungus based on its anti-obesity effect. However, the classif ication of golden-f lower fungi is still controversial; the anti-obesity effect of golden-f lower fungus polysaccharides remains unknown. In this study, we identify a golden-f lower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis, which resolves the controversy of classif ication. Moreover, we f ind A. cristatus polysaccharides (ACPS) attenuate obesity in rats. ACPS modulate gut bacterial composition, in which Akkermansia, Akkermansia muciniphila, Bacteroides, Romboutsia, Blautia, and Desulfovibrio are considered the core microbes regulated by ACPS.ACPS increase fecal total short-chain fatty acid content and serum, hepatic, and fecal total bile acid content. Furthermore, ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity, according to a fecal transplantation experiment. Thus, ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites.

Keywords: Gut microbiota, Obesity, Polysaccharides, Golden-f lower fungus, Aspergillus cristatus

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Received: 13 October 2022
Revised: 02 December 2022
Accepted: 16 January 2023
Published: 08 February 2024
Issue date: May 2024

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© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

Acknowledgements

Acknowledgements

This research was financially supported by Natural Science Foundation of China (32002095 and 32172217), Major Project of Science and Technology of Guangxi Zhuang Autonomous Region (AA20302018), Key Research and Development Program of Hunan Province (2020WK2017), Hunan “Three Top” Innovative Talents Project (2022RC1142), Natural Science Foundation of Hunan Province for Outstanding Young Scholars (2022JJ20028), Training Program for Excellent Young Innovators of Changsha (kq2107015), and Scientific Research Fund of the Hunan Provincial Education Department (20A241).

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