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Food Science and Human Wellness 2024, 13(1): 27-49 https://doi.org/10.26599/FSHW.2022.9250003
Review Article | Open Access | Issue | Published: 01 June 2023

Natural sources, refined extraction, biosynthesis, metabolism, and bioactivities of dietary polymethoxyflavones (PMFs)

Show Author's Information Renyou Gana,b,1( ),  Yi Liua,1,  Hang Lia,  Yu Xiaa,  Huan Guoa,  Fang Gengb,  Qiguo Zhuangc,  Huabin Lid,  Dingtao Wub,( )
Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu National Agricultural Science and Technology Center, Chengdu 610213, China
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering and Technology Research Centre of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
China-New Zealand Belt and Road Joint Laboratory on Kiwifruit, Sichuan Provincial Academy of Natural Resource Sciences, Chengdu 610213, China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China

1 These authors contributed equally to the work.

Peer review under responsibility of Tsinghua University Press.

Keywords:
Gut microbiota, Molecular mechanism, Bioactivities, Nobiletin, O-Methyltransferases
Cite this article:
Gan R, Liu Y, Li H, et al. Natural sources, refined extraction, biosynthesis, metabolism, and bioactivities of dietary polymethoxyflavones (PMFs). Food Science and Human Wellness, 2024, 13(1): 27-49. https://doi.org/10.26599/FSHW.2022.9250003
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Abstract Full text Electronic supplementary material About this article

Polymethoxyflavones (PMFs) are a type of uncommon dietary flavonoids, characterized by more than one methoxy group, which exist in limited plant species, like Citrus species and Kaempferia parviflora. In addition, different PMFs, such as nobiletin, sinensetin, tangeretin, and casticin, have been isolated from these natural sources. PMFs have received increasing attention due to their multiple bioactivities, such as antioxidant, anti-inflammatory, anti-cancer, metabolic regulatory, immunoregulatory, neuroprotective, and skin protective effects. These bioactivities of PMFs should be associated with the regulation of critical molecular targets and the interaction with gut microbiota. In order to provide a comprehensive and updated review of PMFs, their natural sources, refined extraction, biosynthesis, metabolism, and bioactivities are summarised and discussed, with the emphasis on the molecular mechanisms of PMFs on regulating different chronic diseases. Overall, PMFs may be promising flavonoids to the forefront of nutraceuticals for the prevention and/or treatment of certain human chronic diseases.


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Electronic supplementary material
About this article

Natural sources, refined extraction, biosynthesis, metabolism, and bioactivities of dietary polymethoxyflavones (PMFs)

Show Author's information Renyou Gana,b,1( ), Yi Liua,1, Hang Lia, Yu Xiaa, Huan Guoa, Fang Gengb, Qiguo Zhuangc, Huabin Lid, Dingtao Wub,( )
Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu National Agricultural Science and Technology Center, Chengdu 610213, China
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering and Technology Research Centre of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
China-New Zealand Belt and Road Joint Laboratory on Kiwifruit, Sichuan Provincial Academy of Natural Resource Sciences, Chengdu 610213, China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China

1 These authors contributed equally to the work.

Peer review under responsibility of Tsinghua University Press.

Abstract

Polymethoxyflavones (PMFs) are a type of uncommon dietary flavonoids, characterized by more than one methoxy group, which exist in limited plant species, like Citrus species and Kaempferia parviflora. In addition, different PMFs, such as nobiletin, sinensetin, tangeretin, and casticin, have been isolated from these natural sources. PMFs have received increasing attention due to their multiple bioactivities, such as antioxidant, anti-inflammatory, anti-cancer, metabolic regulatory, immunoregulatory, neuroprotective, and skin protective effects. These bioactivities of PMFs should be associated with the regulation of critical molecular targets and the interaction with gut microbiota. In order to provide a comprehensive and updated review of PMFs, their natural sources, refined extraction, biosynthesis, metabolism, and bioactivities are summarised and discussed, with the emphasis on the molecular mechanisms of PMFs on regulating different chronic diseases. Overall, PMFs may be promising flavonoids to the forefront of nutraceuticals for the prevention and/or treatment of certain human chronic diseases.

Keywords: Gut microbiota, Molecular mechanism, Bioactivities, Nobiletin, O-Methyltransferases

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Received: 29 March 2022
Revised: 12 May 2022
Accepted: 20 June 2022
Published: 01 June 2023
Issue date: January 2024

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© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

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This work was supported by the Local Financial Funds of National Agricultural Science and Technology Center, Chengdu, China (NASC2021KR01) and the Agricultural Science and Technology Innovation Program (ASTIP-IUA-2022002).

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