Herbal Remedies: Promisingly Effective for Rheumatoid Arthritis

Rheumatoid arthritis is most significant and devastating to the human body. It is an autoimmune disorder that affects almost 2-4% of the population of the world. Rheumatoid arthritis usually occurs when the immune system works against one’s own body and attacks it. Rheumatoid arthritis generally affects the joints like wrists, elbows, knees and ankles. Even though the reason for causing RA is unknown, the contributing factors for the development of the RA are of various types. Usually women are more affected by RA then men due to the prevalence of hormonal changes. Age is also an important factor that contributes for the development of RA. The general treatment approach for rheumatoid arthritis is to prevent further damage of joints and lower the inflammation and pain. Symptomatic treatment is also the base for RA treatment in many patients. Considering these side effects and limited use of the synthetic drugs, a deep focus has been put into herbal drugs as useful remedies to treat RA successfully. So there has been as growing trend towards development of polyherbal formulation employing potent herbs to treat the disease. Scientific investigations had been carried out to prove the potency of the herbs to treat RA in various animal and invitro models. Many polyherbal formulations had been marketed successfully and were prescribed by the physician. In this view the standardization stands as utmost important parameter for proving the quality of the formulation. Considering the marketed formulations attempts are to be made to determine the quality and effect of the herbal formulations. Investigations are also to be made to determine the interaction between the herbs employed in the formulation. 

RA are of various types. Usually women are more affected by RA then men due to the prevalence of hormonal changes. Age is also an important factor that contributes for the development of RA. The general treatment approach for rheumatoid arthritis is to prevent further damage of joints and lower the in lammation and pain. Symptomatic treatment is also the base for RA treatment in many patients. Considering these side effects and limited use of the synthetic drugs, a deep focus has been put into herbal drugs as useful remedies to treat RA successfully. So there has been as growing trend towards development of polyherbal formulation employing potent herbs to treat the disease. Scienti ic investigations had been carried out to prove the potency of the herbs to treat RA in various animal and invitro models. Many polyherbal formulations had been marketed successfully and were prescribed by the physician. In this view the standardization stands as utmost important parameter for proving the quality of the formulation. Considering the marketed formulations attempts are to be made to determine the quality and effect of the herbal formulations. Investigations are also to be made to determine the interaction between the herbs employed in the formulation.

INTRODUCTION
Pains and In lammation are often correlated medical terminologies that refer to redness, rise in temperature and swelling of the area. Arthritis is derived from two words; arth meaning joint and it is meaning in lammation. Arthritis is one of the presentations of in lammation which affects various joints in the body like hips, knees, spine and other places. They usually affect all the joints weight bearing and non weight bearing types. The symptoms are related to in lammation like pain, rigidity; fatigue generalized weakness and swelling of joints. If it left untreated, it will lead to the damage of joint, destruc  (Firestein and McInnes, 2017).
Out of all the types of arthritis, Rheumatoid arthritis is most signi icant and devastating to the human body. It is an autoimmune disorder that affects almost 2-4% of the population of the world. Rheumatoid arthritis usually occurs when the immune system works against one's own body and attacks it. This attach takes place near the joints and other mobile areas due to the presence of cartilage and certain enzymes. This occurs due to the malfunctioning of the immune system where the reason for this is still not known. The symptomatic onset starts over a long period of time when the joints and cartilages are more affected (Kobelt, 2009).
Rheumatoid arthritis generally affects the joints like wrists, elbows, knees and ankles. Even though the reason for causing RA is unknown, the contributing factors for the development of the RA are of various types. The reasons being given most priority are the genetic history of the disease in family. This factor contributes for about 25% of the total RA cases. Usually women are more affected by RA then men due to the prevalence of hormonal changes. Age is also an important factor that contributes for the development of RA. People of 40-60 yrs of age commonly develop RA although they can develop the disease at any age. Though the disease affects the people at prime age, geriatrics are affected by symptoms more adversely than others. Mobility issues and other pain related issues make the disease much worse in old age people (Saag et al., 2008). RA is neither an infectious nor a contagious disease. Few life style related habits also contribute to RA like smoking and sedentary life style and stress.

Treatment of RA
The general treatment approach for rheumatoid arthritis is to prevent further damage of joints and lower the in lammation and pain. Symptomatic treatment is also the base for RA treatment in many patients. Pain is the most important symptom that is aimed to control at the basic level. With the invention of Anti-rheumatic disease modifying drugs (DMARD's), the medication pro iles of the treatment of RA has drastically changed. In symptomatic treatment there are two kinds of drugs.
NSAIDs-these are Non Steroidal anti-in lammatory drugs that are used to treat in lammation and relieve pain that is caused due to arthritis. These medicines cause only symptomatic relief from the arthritic pain but do not prevent the progressive damage caused due to the disease. The NSAID drug suppresses the pain but do not cure RA. Scienti ic literature also supports the disadvantage of these drugs in treating the disease as such (Deighton et al., 2009).
The other class of drugs is the corticosteroid class. These are hormonal similar and steroid in nature. They are similar to those hormones produced in the adrenal glands and the most important use of those drugs being the anti-in lammatory activity that is similar to cortisol drug. These drugs control in lammation and are slow acting. It may take a longer duration of treatment than expected to treat arthritis. But the use of steroids should be limited to shorter periods to avoid side effects.

Herbs used to treat RA
Considering these side effects and limited use of the synthetic drugs, a deep focus has been put into herbal drugs as useful remedies to treat RA successfully. So there has been as growing trend towards development of polyherbal formulation employing potent herbs to treat the disease. Scienti ic investigations had been carried out to prove the potency of the herbs to treat RA in various animal and invitro models. The below is the list of herbs that had been proven to possess anti-rheumatic property and the valid scienti ic results had been published in research papers (Chandrasekar and Chandrasekar, 2017;Kadhim et al., 2016) (Table 1).

Polyherbal formulations
The herbal drugs were found to be potent and safe in treating RA effectively. There was a rising concern on the usage of herbs as whole. So the polyherbal formulations had been prepared and standardized by various companies and of icially marketed as the RA drugs. These formulations were branded across in the medical market in the form of various formulations. These formulations utilize the ancient knowledge of ayurveda and other systems of traditional medicine and incorporate them into the scienti ic research ( Table 2). The polyherbal formulations are prepared using modern techniques and advanced machinery in large scale (Sara and Sailaja, 2019).

DISCUSSION
The only major hurdle for these polyherbal formulations is the drug-drug interactions which is common in herbs especially when the active principle in the herb is potent. The herbal interactions make the situation more badly as the interactions are hard to estimate and analyze. This western concept of combining drugs and treating the disease is remarkable but with limited use when it come to herbs. So the prior study about the herbs and their chemical composition is necessary before incorporating  et al., 2011). This also gives a hope to the patients and scientists that emerging trends in the formulation development incorporating herbs is best to treat the disease effectively. There had been studies that showed synergy between herbs when used concurrently and this can be used for the fullest advantage for treating the disease successfully. With all this investigations we can also hope that the disease can be treated better while offering a cure and treating the symptoms at the same time (Petchi and Para suraman, 2015).

CONCLUSIONS
There were numerous plants and medicinal herbs that are used to treat Rheumatoid arthritis. Most of them were investigated to prove the activity too. The herbs had been incorporated into herbal formulations that are used to treat the disease effectively. Many polyherbal formulations had been marketed successfully and were prescribed by the physician. In this view the standardization stands as utmost important parameter for proving the quality of the formulation. Considering the marketed formulations attempts are to be made to determine the quality and effect of the herbal formulations. Investigations are also to be made to determine the interaction between the herbs that are employed in the formulation.