Prevalence of Temporomandibular Joint Disorders Among Dental Patients in A Private Institution

Nor Masitah Mohamed Shukri1, Santhosh Kumar M P*2, Arthi Balasubramaniam3 1Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India 2Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India 3Department of Public Health Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India


INTRODUCTION
According to the American Academy of Temporomandibular Disorders, "temporomandibular disorders or dysfunctions (TMD) is a collective term that encompasses many clinical problems involving the masticatory muscles, the temporomandibular joints (TMJ) and associated structures or both" (American Academy of Orofacial Pain, 1993;Silveira et al., 2007). It collectively involved the pain and fatigue of cranio-cervico-facial muscles with the irregular of mandibular movement and clicking sound (Habib et al., 2015). The incidence rate of TMD and associ-ated structures are oftentimes seen in childhood and adolescence than that in adulthood. Also, the American Academy of Pediatric Dentistry recognizes that TMJ disorders in childhood presents with mild signs and symptoms (Sönmez et al., 2001).
In general, TMD can be classi ied into articular and nonarticular disorders, also known as intracapsular and extracapsular, respectively. Myopathies, myofascial pain, ibromyalgia and muscle strains are the scope of nonarticular disorders. The most common nonarticular disorder is presented as myofascial pain that is mainly caused by the extreme activity of clenching and parafunctional habits. Articular disorder is related to the disc-condyle relationship, which is further divided into in lammatory and nonin lammatory arthropathies. They are osteoarthritis, trauma, ankylosed disc, rheumatoid arthritis and pseudogout. The interference between mandibular condyle and articular disc may produce popping sound during jaw opening or closing (Rossi et al., 2014).
The reported prevalence of TMD in adolescence and adulthood is within the range of 4.9% to 60% with the incidence increasing with age. Studies demonstrated most adults reported features of TMD developed since childhood (de Paiva Bertoli et al., 2018). The symptoms of TMD include tenderness in the areas of head and face, preauricular and cervical spine, muscle fatigue of craniofacial and mastication region and irregularity of jaw movement and articular sounds (Dimitroulis, 1998;Callahan, 2000;CRANIO ® , 2003;Minghelli et al., 2014). Studies showed that painful symptoms in TMD are re lected by the spasm of the muscles of mastication, which is mainly due to postural deviation, malocclusion, parafunctional habits such as clenching of teeth, masticatory muscular dysfunction and emotional disturbances (Dimitroulis, 1998;Roda et al., 2007). Psychological factors such as anxiety, stress and depression also account for the pathogenesis of TMD. The painful symptom of TMD becomes more severe in people that are highly related with aggravation of emotional tension (Minghelli et al., 2014). The functional balance between teeth occlusion, muscles of mastication and TMJ are disturbed and deranged, attributing to the combination of postural, structural and psychosocial factors (Silva et al., 1993).
The pathogenesis of TMD related to emotional distress can be explained when severe forms of tension can develop constant teeth clenching, thereby alteration of ions in cell membranes and local muscle circulations. This mechanism results in pooling of lactic and pyruvic acids, in turn, leads to the stimula-tion of pain receptors (Cestari and Camparis, 2002). The complex etiologies, wide variation of clinical features and its requirement of multiple diagnostic methods and therapeutic management to reduce the symptoms are the importance that has led to the increase of studies based on the epidemiology and etiopathogenesis of TMDs (Boever and Steenks, 1996). In regards to the above matter, more and more epidemiological studies of TMDs have been conducted over the decades with the association of patient and nonpatient population. Schiffman et al. showed that more than 60% of the subjects have one TMD sign and an estimated 35% mild TMD symptoms (Fricton et al., 1988).
Our previous publications had been covered on clinical trials (Jesudasan et al., 2015;Christabel et al., 2016;Abhinav et al., 2019b,a), prospective studies (Marimuthu et al., 2018;Kumar, 2017a;Patil et al., 2017;Rao and Kumar, 2018;Jain et al., 2019), systematic reviews (Packiri, 2017;Kumar, 2017b) and epidemiological surveys Kumar and Sneha, 2016;Rahman and Kumar, 2017;Patturaja and Pradeep, 2016). Considering the lack of retrospective studies investigating the prevalence of TMDs based on the types of similar population, thus this study was aimed to evaluate the incidence rate, age and gender differences of TMDs among patients reported to the Saveetha Dental College and Hospital.

Study design and Study setting
This retrospective cross-sectional study was conducted in Saveetha dental college and hospital, Saveetha University, Chennai, to evaluate the prevalence of temporomandibular joint disorders among dental patients reporting from June 2019 to March 2020. The study was initiated after approval from the institutional review board and it was covered by the following ethical approval number; SDC/SIHEC/2020/DIASDATA/0619-0320.

Study population and sampling
Inclusion criteria for the study were patients with no history of orthodontic treatment and at least 11 years old. Exclusion criteria included history of trauma to the TMJ, immunocompromised patients, having dental prostheses, dental anomalies, systemic diseases with cognitive problems and speech problems, missing or incomplete data. After assessment in the university patient data registry, case records of 79 patients who were diagnosed with TMD and were eligible for the study were included in the study. Cross veri ication of data for errors was done with the help of an external examiner.

Data collection
Data regarding patients having TMD were retrieved after analyzing 86000 case sheets. The following parameters were evaluated based on the dental records; age, gender and types of TMD. Chief complaints, medical and dental history and treatment report of the patients were examined for the data collection. Patients diagnosed with TMD were further classi ied into disc-condyle disorder, degenerative disorder and myofascial pain and dysfunction syndrome (MPDS).

Statistical Analysis
The collected data was validated, tabulated and analysed with Statistical Package for Social Sciences for Windows, version 23.0 (SPSS Inc., Chicago, IL, USA) and results were obtained. Categorical variables were expressed in frequency and percentage; and continuous variables in mean and standard deviation. Chi-square test was used to test associations between categorical variables (age, gender and types of TMD). P-value < 0.05 was considered statistically signi icant.

RESULTS AND DISCUSSION
In this study, we evaluated the incidence of TMD among the patients attending our college and its association with gender and age groups. The prevalence of temporomandibular disorders was higher in female patients (51.9%) than male patients (48.1%). X-axis represents the gender male or female while, Y-axis represents the number of patients with TMD. Yellow denotes males and oranges denotes females. TMD was present slightly more in Females (51.9%) compared to males (48.1%) [ Figure 1]. The most frequent age group affected by temporomandibular disorders was 31-40 years (36.7%). X-axis represents age groups. Yaxis represents the number of patients with TMD. TMD was observed more in the age group of 31-40 years (36.71%), followed by 21-30 years (30.38%), 41-50 years (13.92%), 11-20 years (11.39%) and 51-60 years (7.59%) [ Figure 2]. Disc-condyle disorder (75.9%) is the most frequent sub-type of diagnosed temporomandibular disorders and the least recorded was degenerative disorders that were seen only in two patients. Xaxis represents the types of TMD. Y-axis represents the number of patients with TMD. Beige denotes MPDS, green denotes disc-condyle disorder and blue denotes degenerative disorder. Disc-condyle disorders (75.95%) was predominantly present among the patients followed by MPDS (21.52%) and degen-  Figure 3]. There was increased prevalence of degenerative and disccondyle disorders in females than in male subjects. However, there was no statistical signi icant correlation of TMDs in different ages and gender. Xaxis represents age groups and Y-axis represents frequency of patients with different types of TMD. Beige denotes MPDS, green denotes disc-condyle disorder and blue denotes degenerative disorder. Chi-square test was done and association was found to be statistically not signi icant between age groups and TMD. Chi-square test value -4.113, p=0.847 (>0.05). Disc-condyle disorder was predominantly present among all age groups compared to other types of TMD, however this was statistically not signi icant. X-axis represents gender and Y-axis represents frequency patients with TMD. Beige denotes MPDS, green denotes disc-condyle disorder and blue denotes degenerative disorder. Chi-square test was done and association was found to be statistically not signi icant between gender and TMD. Chi-square test value -2.014, p=0.365 (>0.05) and the results are statistically not signi icant. Females (39.24%) presented with a slightly higher number of disccondyle disorders compared to males (36.71%), however this was statistically not signi icant. [Figure 4 and Figure 5].
In our study, the prevalence of TMD was more in female patients (51.9%) than in male patients (48.1%). Our study results were similar to that of other studies in which TMD was found to be 3-6 times more prevalent in women than in men (Biondi and Picardi, 1993;Mcneill, 1997). Our indings are consistent with a study by Bonjardim et al. that reported the percentage of women (57.43%) with TMD is higher than that of men (42.11%) (Bonjardim et al., 2009). A study in Karnataka had concluded women (52.22%) were affected more with TMD symptoms compared to men (50.86%). The percentage of women (16.42%) with moderate TMD degrees was greater than men (10.34%) in the Karnataka population (Syeda et al., 2012).
Garcia et al. in a sample of 122 students reported 68.85% of them were women with some degree of signs and symptoms (Garcia et al., 1997). Although a higher percentage of women than men had been diagnosed with TMD, the difference was not statistically signi icant. Concurrently, Syed et al. in a study of 250 outpatients found the difference was not statistically signi icant. Despite this, there have been some theories suggested for the female predominance in TMDs. According to the postulation, females are more subjected to mental and emotional disturbances than men. They are sensitive human beings and hence severe psychological symptoms were observed in women. Besides, females are more concerned about general health as they are suggested to seek treatment more often than men (Syeda et al., 2012).
In our study, higher prevalence of TMD was observed between age 31 and 40 years (36.7%) than other age groups. The least affected age group was in the range of 51-60 years (7.6%). Few investigations revealed the prevalence of TMDs varies with age. Children, adolescence and elderly demonstrated a low rate of TMD incidence, corroborating with the current study. In women, the severity of TMD symptoms was highly frequent after puberty and rose to the reproductive age group between 20-40 years (Bonjardim et al., 2009). Modi et al. reported 159 subjects of 21-22 years were the most affected with TMD as compared to other 97 subjects who were below 20 years (Modi et al., 2012). A previous study among undiagnosed undergraduate students demonstrated a higher prevalence of TMD in students of 22-23 years (Ha ila et al., 2017). The prevalence of TMD can affect any individual of any age group, with a higher proportion seen in women aged 20-45 years (Minghelli et al., 2014). The difference could be due to social background of the sample size population and methods of diagnosis.
In our study, similar to gender predilection, there was no statistically signi icant difference between age and TMDs. This concluded that age, as a factor, was not signi icant in the prevalence of TMJ disorder. Karthick et al. also found the same signi icant indings (Ha ila et al., 2017). In contrast, Menghelli et al. and Bertoli et al. showed students in older age signi icantly were prevalent of developing TMDs (de Paiva Bertoli et al., 2018;Minghelli et al., 2014). The different consensus obtained were more likely affected with the age limit of the subjects and severity of the TMDs.
Disc-condyle disorder (75.9%) is the most frequent sub-type of diagnosed temporomandibular disorders and the least recorded was degenerative disorders that were seen only in two patients in this study. 17 patients from the study had myofascial pain and dysfunction syndrome (21.5%). In study of Brazilian adolescence, 10.3% of the sample study was diagnosed with myofascial pain, which was more prevalent in girls. 8% had disc displacement and 3.5% had arthralgia. In contrary to this study, few studies had reported myofascial pain as the most common diagnosis for TMDs. No case of disc displacement and osteoarthrosis were detected (de Paiva Bertoli et al., 2018;Franco-Micheloni et al., 2015;Kobayashi et al., 2014).
The limitations of this study include its small sample size distribution, geographic factors and associated signs and symptoms of TMDs were not mentioned. The present study is a pioneering study, therefore there is a need for long-term clinical investigations to be conducted in this region. This study will help to promote awareness of this disorder on the national level.

CONCLUSION
Within the limits of this study, TMDs were prevalent in females of age between 31 and 40 years, with disc-condyle disorder being the most prevalent type. TMD was signi icantly more common in women, but menarche was not associated with the prevalence of TMD in this sample. Considering that symptoms can be more prevalent with increasing age, clinicians and dental practitioners should be actively prepared to diagnose TMD signs at early stages for better therapeutic and clinical management.