Awareness on the wound healing effects of curcumin therapy among dental students

Turmeric also known as Curcuma longa is a rhizome used commonly in traditional medicines for decades to treat a number of in lammatory disorders and other ailments. Its therapeutic properties were primarily attributable to curcuminoids. The purpose of the study was for assessment of awareness of Curcumin’s wound healing effects amongst dental students. A cross sectional studywasdonewith a self-administeredquestionnaire comprising of 10questions circulated among 100 dental students. The questionnaire assessed the awareness about wound healing effects Curcumin therapy, their effect on collagen expression, the effect on neovascularization, effect on reepithelization and effect on free radical scavenging. The responses were recorded and analysed.78% of the respondents were not aware of the wound healing effects of curcumin therapy. 84% were not aware of the effect of curcumin in collagen expression. 88% were not aware of the effect of curcumin on neovascularization. 80% were not aware of the effect of curcumin on reepithelization. 94%were not aware of the effect of curcumin on free radical scavenging. The awareness about the use of Curcumin therapy in wound healing applications is very less among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modi ications should be incorporated to improve the awareness levels.

tions circulated among 100 dental students. The questionnaire assessed the awareness about wound healing effects Curcumin therapy, their effect on collagen expression, the effect on neovascularization, effect on reepithelization and effect on free radical scavenging. The responses were recorded and analysed.78% of the respondents were not aware of the wound healing effects of curcumin therapy. 84% were not aware of the effect of curcumin in collagen expression. 88% were not aware of the effect of curcumin on neovascularization. 80% were not aware of the effect of curcumin on reepithelization. 94% were not aware of the effect of curcumin on free radical scavenging. The awareness about the use of Curcumin therapy in wound healing applications is very less among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modi ications should be incorporated to improve the awareness levels.

INTRODUCTION
Turmeric also known as Curcuma longa is a rhizome used commonly in traditional medicines for decades to treat a number of in lammatory disorders and other ailments.
Curcumin plays a major role in enhancing healing mechanism in human body. Healing process and tissue repair are complex processes, including swelling, granulation and tissue reconstruction. Tissue damage starts a dynamic cascade that involves interactions with a variety of cells, several cytokines, developmental factors, their accomplices and extra-cellular matrix proteins. Community use of turmeric is a very common treatment practice in India for several ailments, trauma, wound healing, ulcers, cutaneous diseases , insect bite and viral chickenpox (Gribb, 1929).
In view of the antiquated utilization of turmeric in the wound healing process, prior examinations assessed the impact of curcumin on the improvement of wound healing (Aggarwal et al., 2007). The purpose of the study was for assessment of awareness of Curcumin's wound healing effects amongst dental students.

MATERIALS AND METHOD
A cross sectional survey was done with a selfadministered questionnaire with 10 questions circulated among 100 dental students. The questionnaire assessed the awareness about wound healing effects Curcumin therapy, their effect on collagen expression, the effect on neovascularization, effect on repithelization and effect on free radical scavenging. The responses were recorded and analysed.

DISCUSSION
Curcumin conditioned wound biopsies revealed an immense amount of cell migration of neutrophils, macrophages and the ibroblasts, relative to untreated wounds. The expression of myo ibroblast in the curcumin administered wounds showed faster compression of wounds (Sidhu et al., 1999). Metamorphosis of several cells is the anticipated source of growth factors required to regulate healthy mechanisms during wound healing. The Transforming growth factor (TGF-β1) is very important for wound healing because it enhances ibronectin (FN) and collagen synthesis by ibroblasts and enhances the amount of granulation tissue in vivo. Curcumin therapy culminated in increased ibronectin (FN) and collagen function (Marques et al., 2017).
In addition, treatment with curcumin resulted in improved organization of granulation tissue, improved cell material, neo-vascularization and rapid re-epithelialization of wounds in diabetic and hydrocortisone-disrupted wounds, by controlling the expression of the TGF-β1, its receptors and nitric oxide synthase throughout wound healing (Mani et al., 2002;Sidhu et al., 1998). Several studies, including the fundamental entity of curcumin, have shown its useful impacts by enhancing muscle recovery after injuries in vivo through regulating NF-£B activity (Roach et al., 2007).
Recent research has indicated curcumin prevents damage done due to hydrogen peroxide in mammalian keratinocytes and ibroblasts, suggesting cell reinforcement work in enhanced wound repairs (Krutmann and Humbert, 2010). Therefore, curcumin treatment exhibited enhanced wound reduction, better cell proliferation and suf icient free radical rummaging compared to control and the collagen-treated rodents (Gomathi et al., 2003;Gopinath et al., 2004). Curcumin supplementation enhanced the combination of hexosamine, collagen, nitrite, DNA and histological examination of wound biopsy specimens illustrated elevated collagen assertion and an improvement in ibroblast and the vascular density indicating curcumin might be able to strengthen radiation-actuated deferral in wound healing (Jagetia and Rajanikant, 2005).
Curcumin is noted for its antiulcer activity in an ulcer model in rodents by reducing glutathione exhaustion, lipid peroxidation and protein degradation. The denudation of the cell membrane during damage to the gastric lumen is overcome by curcumin by re-epithelialisation. In addition, both the oral and the intraperitoneal structure of curcumin inhibited the gastric ulceration in partly subjugated manner. It improved healing process and assured gastric ulcer healing by reducing the mobility of MMP-9 and enhancing the action of MMP-2. It is evident from these investigations that curcumin therapy has resulted in faster wound healing, far better control of the formation of granulation tissue and recognition of the growth factors (Aggarwal et al., 2007). It suggests that the improvement of wound repairs be demonstrated at different stages. Further research is needed for evaluating curcumin as a potentially bene icial operator in the clinical domain of wound healing.

CONCLUSION
The awareness about the use of Curcumin therapy in wound healing applications is very less among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modi ications should be incorporated to improve the awareness levels.