Prevalence of smoker’s palate and smoker’s melanosis among patients visiting a private dental college

Nor Syakirah binti Shahroom1, Manjari Chaudhary*2, Iffat Nasim3 1Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India 2Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India 3Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India


INTRODUCTION
Tobacco dependence is a serious public health problem. Smoking or chewing tobacco are deleterious to oral health and it promotes the development of oral cancer, premalignant lesions and other oral mucosal lesions such as leukoplakia, smoker's palate (nicotinic stomatitis), smoker's melanosis and chewer's mucosa (Mirbod and Ahing, 2000;Steele, 2015;Muthukrishnan and Kumar, 2017;Warnakulasuriya and Muthukrishnan, 2018). In potentially malignant disorder, the alteration to the oral mucosa can alter the expression of Matrix MetalloProteinase-9 (Venugopal and Maheswari, 2016). Consumption of tobacco especially smoked form are not only harmful to the smoker's but may also affect the health of the infants or adults who inhale the smoke. It may cause the development of other chronic diseases such as pulmonary diseases, cardiovascular diseases, gastroenteral diseases and malignancies (Luo, 2007). Very rarely, metastatic malignancies of the oral cavity occur (Misra, 2015). Cancer treated with radiotherapy is more prevalent to oral mucositis compared to chemotherapy (Chaitanya, 2017). Sometimes, cancer patients may experience neuropathic pain (Chaitanya, 2018;Subha and Arvind, 2019). Thus, it is said that general health and oral health are both equally important (Subashri and Maheshwari, 2016;Choudhury, 2015;Rohini and Kumar, 2017;Patil, 2018). In India, it was estimated that 47% of the individuals who consumed tobacco use tobacco where 72% smoke bidis and 12% smoke cigarettes (Singla and Verma, 2016). Various commercial preparations are known as pan masala and gutkha have become available in India (McCullough et al., 2010).
Oral mucosal lesions are frequently seen in elderly and males (Jindal, 2006;Patil et al., 2013;Rohini et al., 2020). The elderly population have high risk in developing pathologies due to increasing development of systemic diseases, age-related metabolic changes, nutritional de iciencies, medicationrelated and deleterious habits such as tobacco and alcohol consumption (Rohini et al., 2020). While treating elderly patients, it is important to take a proper drug history as some drugs may cause changes to the oral mucosa . The type, frequency and duration of tobacco usage may in luence the clinical appearance, location and extent of the oral mucosal lesion (Bhonsle, 1992;Behura et al., 2015). Severe effects of the long term usage of tobacco may be seen on the oral mucosa (Aljabab et al., 2015).
Another name for smoker's palate is nicotinic stomatitis. It is an asymptomatic lesion usually associated with cigar, heavy pipe, cigarette smoking and reverse smoking. The clinical features of smoker's palate include changes in colour to white with multiple red dots seen in the hard palate and small elevated nodule (Singla and Verma, 2016). It may also cause in lammation to the opening of minor salivary glands due to chronic heat during smoking. It is painless but may be associated with itching or burning sensation (Singla and Verma, 2016). A biopsy is used for diagnosing oral mucosal lesions and is known as the gold standard (Dharman and Muthukrishnan, 2016).
The term smoker's melanosis was irst coined by (Hedin, 1977). It is a benign pigmentation of the oral mucosa (Brad Neville Douglas D. Damm Carl Allen Jerry Bouquot, 2008). It is clinically characterized by a brown to black colouration of the gingiva, palate, buccal mucosa, larynx and pharyngeal wall (Mattoo, 2014). Due to heat from the smoke and stimulation of melanocytes, it results in increased deposition of melanin (Hedin et al., 1993). Histopathological features included para to ortho keratotic strati ied squamous epithelium with prominent granular layer, melanin pigmentation, prominent stratum granulosum, bulbous rete ridges, dense and collagenous connective tissue with mild chronic in lammatory in iltrate (Mattoo, 2014).
Thus, the aim of this study was to evaluate the prevalence of smoker's palate and smoker's melanosis among patients visiting a private dental college in Chennai, India.

MATERIALS AND METHODS
A retrospective study was conducted involving patients visiting a dental hospital from July 2019 till March 2020. Ethical approval for the study was granted by the Institutional Ethics Committee with the following ethical approval number SDC/SIHEC/2020/DIASDATA/0619-0320.
All available cases sheets were reviewed and analyzed. A total of 146 patients were selected based on the inclusion and exclusion criteria. The inclusion criteria were patients diagnosed with smoker's palate and smoker's melanosis. Exclusion criteria were patient without any history of a smoking habit. Cross-veri ication was done using photographs and reviewed by the second reviewer to minimize bias.
Data were retrieved from the records which include socio-demographic data such as age and gender and patients diagnosed with smoker's palate and smoker's melanosis. Data analysis was done using Statistical Package for Social Sciences SPSS version 20. A Chi-square test was used to determine the association between the age and oral mucosal lesion.

RESULTS AND DISCUSSION
One hundred and forty-six patients were selected. Among them, all patients were males. The mean age was 48.4 and ranged from 20 to 79 years old and categorized into six age groups: 20-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years and 70-79 years.

Figure 3: Thebar chart represents the association of age with oral mucosal lesion.
A previous study reported smoker's melanosis was the most commonly observed oral change with 43.28% followed by leukoderma (27.05%) and smoker's palate (22.76%) (Aljabab et al., 2015). Similarly, in a study done by (Behura et al., 2015), smoker's melanosis was more prevalent among patients with habits with 29% and smoker's palate with 6% (Behura et al., 2015). Few studies reported that smoker's palate was the second most preva-lent oral mucosal lesion (Mathew, 2008;Alshayeb, 2019;Rohini et al., 2020). No study has reported any prevalence on the combination of both smoker's palate and smoker's melanosis.
According to the age, this present study reported that 50-59 years' age group was more prevalent to be diagnosed with smoker's palate or smoker's melanosis. Similarly, previous studies reported that oral mucosal lesions were commonly seen in elder patients (Patil et al., 2013;Alshayeb, 2019;Saberi et al., 2019;Rohini et al., 2020). Elderly individ-uals are vulnerable to oral mucosal lesions when compared to younger individuals (Rohini et al., 2020). Studies reported that there was an association between oral mucosal disorders with ageing (Moreira, 2005) and smoking and age are signi icant risk factors for oral mucosal lesion (Gönül, 2011). However, this study revealed that there was no statistically signi icant difference between age and oral mucosal lesion in line with this previous study (Alshayeb, 2019).
Smoker's palate and smoker's melanosis were commonly seen in patients with a smoking habit. Sometimes, smoker's melanosis can be seen in patients with mixed habits (Behura et al., 2015). Studies revealed that bidi smoking manifested smoker's palate more often and found to be more harmful than cigarette smoking (Kumar, 2010;Singla and Verma, 2016). The most common site of smoker's melanosis was buccal mucosa of the patient who smoked using pipe and in the palate in reverse smoking lesion (Müller, 2010).
One of the limitations in this study was small sample size. However, bias was minimized by crossveri ication and random strati ied sampling method. Besides, this study was more focused on smoker's palate and smoker's melanosis. Classi ication of other types of oral mucosal lesion can be done in the future study.

CONCLUSIONS
In conclusion, the most prevalent oral mucosal lesion in the present study was smoker's palate followed by smoker's melanosis and combination of smoker's melanosis and smoker's palate. This type of oral mucosal lesion was predominant in males and 50-59 years. Anti-tobacco counselling and cessation of smoking habit should be advised and the ill-effect of tobacco to the health should be explained to the patients.

Author contributions
First author (Nor Syakirah binti Shahroom) performed the analysis, interpretation and wrote the manuscript. Second author (Dr. Manjari Chaudhary) contributed to the conception, data design, analysis, interpretation and critically revised the manuscript. Third author (Dr. Iffat Nasim) participated in the study and revised the manuscript. All the three authors have discussed the results and contributed to the inal manuscript.