Ekal dravya (Single Herbal Drug) exploit in Covid 19 – A Review

Snehal P Khobrgade1, Sneha Rajendra Vidhate*2, Abhijeet Futane3 1Mahatma Gandhi Ayurved College, Hospital & Research Centre, Salod (H), Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra-442001, India 2Department of Dravyaguna, Mahatma Gandhi Ayurved College, Hospital & Research Centre, Salod (H), Wardha, Maharashtra-442001, India 3Department of ENT, Senior Resident, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra-442001, India


INTRODUCTION
While COVID-19 is at present being feasibly controlled inside China, it is continuously affecting various countries around the globe, most unmistakably the U.S, Iran, and Italy since Feb 25, 2020, WHO (Geneva, 2020). Crown contaminations are a colossal gathering of diseases which may cause sickness in animals or individuals. In individuals, a couple of crown diseases are known to cause respiratory de ilements running from the customary infec-tion to progressively genuine illnesses, for instance, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). The most starting late discovered Covid causes COVID-19 (Khamis et al., 2020). These globules are commonly overpowering, don't go far and quickly sink to the ground. People can get COVID-19 if they take in these dabs from an individual spoiled with the disease. This is the explanation it is basic to stay at any rate 1 meter) away from others. These dots can show up on things and surfaces around the person, for instance, tables, entryway handles and handrails. People can get corrupted by reaching these things or surfaces, by then reaching their eyes, nose or mouth. This is the explanation it is fundamental to wash your hands reliably with chemical and water or clean with alcohol-based hand rub (Vijai and Joyce, 2020). In the wake of COVID-19 pandemic, there's been a lot of excitement for ways to deal with strengthen one's sheltered system, and thus produce a irst line of obstruction against the ruinous disease. Immunity can't be created in a day, yet luckily eating an in any event, eating routine and being really and mentally powerful is commonly enough to keep your safe system sound. As demonstrated by the World Health Organization, around 80% of the absolute people uses local meds for fundamental human administrations, particularly across Europe and South Asia. Investigation shows that countless these lavors not simply have relieving properties; they in like manner help build up the body's ordinary opposition. Additionally, not at all like allopathic medications like an enemy of disease operators, which can have veritable manifestations, an enormous bit of these lavors and lavors are commonly secured (Akanksha Srivastava, 2020).

MATERIALS AND METHODS
Ayurvedic Scriptures, Scienti ic diaries, Internet sites and distributed article were utilized. Being a transferable sickness, social removing and building one's resistance can be an aid to dispose of this pandemic. Ayurveda by methods for the Rasayanas can help at its best to defeat this pandemic. A portion of the single homegrown medication and Rasayanas can be utilized for the equivalent. There are some single natural medications and Rasayana drug which go about as an immunomodulatory.

RESULTS AND DISCUSSION
In Ayurvedic scripture, there are some drugs which are which act as an immune-modulator drug single or combine are as follow.

Haridra (Curcumin longa)
Evidence recommend that Haridra (curcumin longa) has an inhibitory potential against various viral de ilements. The antiviral effects of curcumin were seen against diseases including vesicular stomatitis contamination, parain luenza contamination type 3, vesicular stomatitis contamination, group house disease, herpes simplex contamination, and respiratory syncytial disease (Zorofchian et al., 2014). Curcumin in luences layer proteins by directing the traits of the host lipid bilayer used sub-nuclear mooring with target receptors including SARS-CoV-2 protease, spike glycoprotein-RBD, and PD-ACE2, which are acknowledged to check out contamination infection in assessment with the alluded to ligand or drugs as references (Chen et al., 2013).

Indhana (Artemisia annua)
Artemisinin is subordinates of A.annua that have been promoted as antimalarial drugs (Efferth et al., 2011). The extended reality, interceded by Interleukin-1. A couple of assessments suggesting that oxidative weight is connected with aspiratory illnesses and in all likelihood, the use of customary malignancy avoidance operators is feasible in lung ibrosis A. annua to remove shows basic malignant growth counteraction specialist development that is more then likely in view of its high phenolic content (Ferreira et al., 2010). A. annua subordinates, artesunate, is a promising novel prescription to treat aspiratory ibrosis by thwarting pro-ibrotic particles related with pneumonic ibrosis (Wang et al., 2015).

Chandrashura (Lepidium sativum)
Lepidium sativum seeds are accepted to reasonable therapeutic answer for respiratory issues, like bronchitis and asthma (Nadkarni and Nadkarni, 1976). The plant is created as a culinary vegetable all over Asia (Baquar, 1989). In South Asia, it is used in standard drug to treat asthma, bronchitis, and hack and is seen as supportive as an abortifacient, antibacterial, sexual enhancer, expectorant, gastrointestinal energizer, gastroprotective, laxative and stomachic (Duke, 2002;Maier et al., 1998).

Ashwagandha (Withania somnifera)
Withania somnifera (L.) Dunal is known as Ashwagandha, one of the most regarded therapeutic plants of the standard Indian structures of drugs, is used more than 100 subtleties of Ayurveda and is accepted to be therapeutically proportionate to Ginseng. W. somnifera has been used as an antiviral zest for the treatment of genital ailment achieved by Herpes Simplex Virus among African tribes and appeared antagonistic to in luenza properties (Balkrishna et al., 2020). The purpose of the current examination is to check the antiviral capacity of W. somnifera trimmings against COVID-19 by strategies for computational methods. The middle explanation of this assessment is to limit or cripple the coordinated efforts between the receptor and  (Khanal et al., 2020).

There are some Rasayana dravyas which is utilized in covid 19 are as follow Chyawanprash
Chyawanprash comprises Amla/Amalaki (Phyllanthus emblica/Indian gooseberry) mash as a base, and this is viewed as the best Rasayana for supporting homeostasis. Chyawanprash that contains Amla has a blended taste, joining sweet, sharp, severe, impactful, and astringent characteristics. On standard admission, it keeps up physiological capacities and restores the entire body framework. In the wake of the Covid 19 lare-up, whole humanity over the globe is languishing. Upgrading the body's characteristic safeguard framework (resistance) assumes a signi icant part in keeping up ideal well being (Sharma et al., 2019).

Guduchi (Tinospora Cordifolia)
Guduchi, probably the best medication and henceforth viewed as the irst in the remainder of the ive Rasayana, because of its adaptability. It is otherwise called "Amrita". Diary of Ayurvedic and Herbal Medicine. Guduchi is Agnideepana, Balya, Jwaraghna and Ama nashaka and helpful for the upper respiratory tract contamination, skin infections, urinary illnesses, dyspepsia, general debility, fever, bronchitis, gout, and so on. On account of its  (Hu et al., 2012). Further, as indicated by Ayurveda works of art, rasayana treatment, alongside physical and social removing from tainted people, establish a center technique to defeat pandemic and irresistible illnesses. Building in susceptibility requires time. There might be some asymptomatic bearers who could transmit the infection to other obviously in solid individuals. Thus, physical and social removing for all future fundamental to evade any transmission (Rastogi et al., 2020). Ayurvedic herbal drugs, for example, Ashwagandha, Guduchi, Yashtimadhu and Amalaki for prophylaxis and the executives of SARS-CoV-2 disease. It is conceivable to spare a large number of lives from SARS-CoV-2 contamination by improving host guard. We guess that adequacy and well-being of current therapeutics might be improved by diminishing power of CRS answerable for ARDS. India has an open door for a worldwide authority in creating proof put together prophylactic and remedial techniques with respect to the premise of Ayurveda.

CONCLUSIONS
In the present study, it is observed that the effect of herbal medicine has an effective role in covid 19.
Most of the herbal drugs act as an immune modulator which grants against covid 19. The ekal dravya (single dravya) as mentioned in table and Kalpa (a combination of a drug) as rasayana is most effective during the pandemic condition of Covid -19. The war against COVID-19 requires a transdisciplinary approach with the involvement of researchers from medicine, science, technology and social sciences.

ACKNOWLEDGEMENT
The author Snehal Khobragade expresses thanks to dean MGACH & RC, DMIMS University Nagpur for providing necessary facilities to carry out the present review on covid 19.