Possible effects of Ayurvedic herbs on management of COVID-19

Corona virus disease COVID-19 is caused by coronavirus that can spread between animals and humans. The most common symptoms are fever, tiredness, and dry cough. Some individuals also develop aches and pains, nasal congestion, runny nose, sore throat, or diarrhoea. It was reported that traditional remedies may alleviate the symptoms of COVID-19. However, a major drawback is a lack of adequate scienti ic basis. Tulsi has multi-modal therapeutic effects, we hypothesize thatTulsimaybe effective in the prevention and management of COVID-19. Though the existing literature supports the management of symptoms of COVID-19 using Tulsi, a lack of standard formulation limits its use. This is the need of time to start with translational research to provide scienti ic evidence for the ef icacy and to establish the standard formulation of Tulsi in the management of COVID-19. Taking these things in to consideration efforts have been made to treat the patients of COVID-19 with Shaman Therapy Herbal Formulations. On the basis of indings and observations obtained after completion of current project it can be concluded that covid19 are progressive degenerative conditions in which Tridosha at its own Ashaya gets provoked and as it belongs to Madhyam Rogamarga treatment becomes challenging. This attemptpossibly inds solutionswhich canprevent. Ayurveda the features like cough, running of nose& sore throat are caused due toDushti (vitiation) ofPranavahaSrotas& alsohavingAnnavahaStrotasDushti & Rasavaha Strotas Dushti. Ayurveda is the world’s oldest medical system that can manage any disease without side effects.


INTRODUCTION
Corona virus disease COVID-19 is caused by the recently discovered corona virus that can spread between animals and humans. An outbreak of pneumonia in December,2019 in Wuhan, China, has now been determined to be caused by a novel corona virus. It is named as Severe Acute Respiratory Syndrome Corona virus 2 (SARS-CoV-2) (Nisargandha and DadaraoParwe, 2020). The most common symptoms found in covid-19 are fever, tiredness, and dry cough (Deshpande and Parwe, 2020). Some individuals also develop aches and pains, nasal congestion, runny nose, sore throat or diarrhoea. As of July 6, 2020, COVID-19 has been con irmed in over 11,301,850 individuals worldwide and has resulted in more than 531,806 deaths (WHO, 2019; Parwe et al., 2020)

METHODS
In order to locate research studies and interventions that examined the therapeutic effect of ayurvedic herbs from Dravya guna, databases were book of dravya guna (Hegde, 2015) searched through google scholar via universities web browser.

RESULTS
Ayurveda is the world's oldest medical system that can manage any disease without side effects. Ayurveda is equipped with varieties of treatment modalities to handle with any type of deadly diseases. However, a major drawback is a lack of an adequate scienti ic basis. To overcome this problem, AYUSH has started encouraging research in several areas to improve the system effectively. One such valuable plant in Ayurveda and Siddha systems is Tulsi. In Indian tradition, Tulsi has a sacred role as it is considered as an avatar of Shri Mahalakshmi. The Sanskrit meaning of Tulsi is "the incomparable one." Off course, this is acceptable in reality, as Tulsi has multiple bene icial effects on the human body. It can balance various mechanisms and increases the life span, according to Charaka Samhita (Claus, 2003). Offering prayer to Tulsi is the irst act to traditional Indian women and men. In fact, Tulsi plant was present in almost every home even today and the leaves of Tulsi are mandatory included in any prayer of Hinduism (Simoons, 1998).

DISCUSSION
The leaves of Tulsi are consumable and are being used to normalize the Kapha and Vata (Das et al., 1983). Tulsi is being used in the management of pain, diarrhoea, cough and fever which are the common symptoms of COVID-19. (Mohan et al., 2011). Tulsi have been used in the management of fever ranging from normal fever to malaria fever. (Mondal et al., 2011) The leaves of Tulsi, in addition with cow ghee, were described as the best medicine for pneumonia. There exists a strong scienti ic evidence for the antiviral effects of Tulsi (Das et al., 1983). Tulsi has been proven to be effective in inhibiting several deadly viruses like Newcastle Disease virus, Vaccine virus and Infectious Bursal Disease virus. (Prakash and Gupta, 2005) Clinical trials conducted earlier in India, where the extract of Tulsi leaves was administered for patients with viral hepatitis and encephalitis. Interestingly there was an increase in the survival and symptomatic improvement in the Tulsi group when compared with controls (Rajalakshmi et al., 1986). Another study proved improvement in respiratory parameters and relief from symptoms of asthma with three days of consumption of Tulsi. (Sharma, 1983) The striking feature in using Tulsi is that it not only restores physiological functions but also restores the psychological functions. Phenolic compounds and antioxidant properties of Tulsi were reported to contribute its therapeutic effects (Pattanayak et al., 2010). Tulsi consumption increases the anti-oxidant molecules and enzymes in the body and protects the cells and its membrane from being damaged by the toxic substances. (Shivananjappa and Joshi, 2012) Tulsi boosts the immunity of the body and helps to defence the threatening virus and bacteria. (Mondal et al., 2009) Improvement in humoral and cellular immunity was observed in animal studies after treatment with Tulsi oil. (Vaghasiya et al., 2010) The possible mechanism for improving immunity is a modulation of the GABA pathway (Das et al., 1983). Due to its multi-modal therapeutic effects, we hypothesize that Tulsi may be effective in the preventions and management of COVID-19. Though the existing literature supports the management of symptoms of COVID-19 using Tulsi, a lack of standard formulation limits its use. This is the need of time to start with translational research to provide scienti ic evidence for the ef icacy and to establish the standard formulation of Tulsi in the management of COVID-19.

CONCLUSION
Tulsi has multi-modal therapeutic effects. It not only restores physiological functions but also restores the psychological functions. Which can be helpful in covid19 pandemic. Tulsi is being used in the management of pain, diarrhoea, cough and fever which are the common symptoms of COVID-19. Tulsi have been used in the management of fever ranging from normal fever to malaria fever. The leaves of Tulsi, in addition with cow ghee, were described as the best medicine for pneumonia. So from above discussion Tulsi can be used as prophylactic medicine in prevention of spreading COVID-19 disease.

Con lict of Interest
The authors declare that they have no con lict of interest for this study.

Funding Support
Supported by DMIMS (DU).