A Review: Coronavirus, Its Types, And Impact of COVID-19 on Global Wealth

The virus can multiply itself and their genetic code mostly includes either RNA or DNA. In many different ways, the various types of viral species are spread. For examples, Human immunode iciency virus is transferred through body luids, plant viruses are transferred from plant to plant by insects and other organisms, Severe Acute Respiratory Syndrome virus transmitted by humans and animals, COVID-19 is a respiratory virus that transmitted mainly through direct contact with an infected individual by respiratory droplets when the infected person coughs or sneezes, or by saliva droplets or nose discharge. Coronaviruses are the viruses that belong to the class Coronaviridae and subclass Ortho-coronavirinae, order Nidovirales. Some human coronavirus infections are mild, but Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) human coronaviruses transmission from animals to humans, have caused more than ten thousand cumulative cases in the past two decades. And now a novel coronavirus namely known as COVID-19 is a unique strain which has not been previously recognized in humans emerged as the most important global health threats. Thus this study aims to assess the awareness of this COVID-19 among the general public and to provide basic information such as signs and symptoms, origin, diagnostic method, treatment, prevention recommended byWHO and impact of COVID-19 on global wealth. Global stock exchange has a drop-down rapidly as stock investors continue toworry about the broader economic effects of the COVID-19.


INTRODUCTION
Coronaviruses are the viruses that belong to the class Coronaviridae and subclass Orthocoronavirinae, order Nidovirales. (Groot et al., 2011). The name "coronavirus" is derived from the Latin word Corona and the Greek word korōńē, which means crown. While evaluating beneath an electron microscope, it noti ies the presence of Virions i.e. the infectious form of the virus, which has a huge fringe, reminiscent of either royal crown or a solar corona. Coronaviruses are enveloped positive-sense RNA virusesstarting from 60 nm to 140 nm in diameter with spike-likeprojections on its outer surface giving it a crown-like appearance under the electron microscope; that is why called as coronavirus. (Richman et al., 2016), (Woo et al., 2010) Coronaviruses are zoonotic pathogens with a high mutation rate which might be present in humans and many animals with a broad range of clinical features from asymptomatic course to requirement of hospitalization in the intensive care unit; inducing infections in respiratory, gastrointestinal, neurologic and hepatic systems. (Drexler et al., 2010), (Yin and Wunderink, 2018) Since 2002 outbreaks of the Severe Acute Respiratory Syndrome (SARS) and in 2012 Middle East Respiratory Syndrome (MERS), the risk of coronavirus transmission from animals to humans has been veri ied. (Cui et al., 2019), (Cauchemez et al., 2013) Human coronavirus shows a major class of coronavirus connected with various multiple respiratory diseases of different severity including common cold, cough, bronchitis, and pneumonia. (Pene et al., 2003) After Severe Acute Respiratory Syndrome more than 20 extra novel coronavirus with complete genome sequences have been recognized (Lau et al., 2011) and presently, seven human coronaviruses were classi ied along with recent 2019 novel coronavirus. These types of human coronavirus are divided into four types such as alpha, beta, gamma, and delta coronaviruses. The irst human coronavirus was diagnosed in 1960 and to present, there are seven human coronaviruses were recognized as follows: Human coronaviruses 229E, NL63, OC43, and HKU1 were generally infected in humans worldwide. Human coronavirus 229E (HCoV-229E) is one of the irst reported types of coronavirus variants. It is associated with common symptoms of cold in healthy adults. (Vassilara et al., 2018) A new human coronavirus (HCoV-NL63) was reported in a seven-month-old infant with respiratory symptoms in Holland in 2004. Subsequently, this virus was found in many countries, indicating a spread worldwide. NL63 (alpha coronavirus) is commonly infected children and those immunocompromised with either mild upper respiratory symptoms like cough, fever, and rhinorrhoea or intense LRTI, which includes bronchiolitis and croup, perceived normally in younger children. (Abdul-Rasool and Fielding, 2010) It is evaluated that 1 to 10 percent of the human population is affected yearly by cold-like symptoms of HCoV-NL63. (Szelazek et al., 2017) While it was understood that human coronavirus OC43 (HCoV-OC43) reported for 5 to 30 percent of human respiratory tract infections. (Vijgen et al., 2006) Both HCoV-OC43 and HCoV-229E affect otitis media and LRTI. Even though the virus-infected person stool containing particles like coronavirus, no proof was observed that both the viruses may affect enteric disease in humans. (Burrell et al., 2017) The irst-class A human -CoVHKU1virus was isolated in 2004 in Hong Kong and was later determined worldwide in humans. Just like other human coronaviruses, this new coronavirus HCoV-HKU1 is also affecting 0.9 percent of LRTI and URTI. (Woo et al., 2009) HCoV-HKU1 like respiratory tract infections are the same as other respiratory viruses.
Mostly the URTI patients reported with fever, dry cough, and running nose; while LRTI patients having fever, productive cough, and dyspnea type of symptoms. Generally, children under the age of six are predicted for exposure to HKU1. (Zhou et al., 2013) Normally, HKU1 infections cause moderate URTI and in some patients, it shows extreme respiratory infections, inclusive of pneumonia in geriatric, pediatric, and patients with immunocompromise. (Gralinski and Baric, 2015) Coronaviruses

COVID-19
The unknown pneumonia case in December 2019 has been reported irstly in Huanan Seafood Market, Wuhan city of china and all other coronaviruses were studied out by testing laboratory. Chinese authorities announced on 7 January 2020 that a new type of Coronavirus i.e. Novel Coronavirus, (nCoV) was reported. (BMJ, 2020) The outbreak of this virus is widening its wings to various parts of the world as faster as that World Health Organization (WHO) has declared this as "Public Health Emergency of International Con-cern". (Imai et al., 2020) On 12 January 2020, WHO temporarily named the virus (2019-nCoV) and inally named COVID-19 on 11 February 2020. (Rai et al., 2020)Numbers of new cases are identi ied, primarily in Ten Asian countries (Table 1). (Worldometer, 2020)

Origin
How COVID-19 came to Wuhan city of China is presently unknown, but 66 percent of the initially reported cases (27/41) were directly connected to the Huanan Seafood market, Wuhan city of China. (Huang et al., 2020) Transmission COVID-19 is a respiratory virus that transmitted mainly through direct contact with an infected individual by respiratory droplets when the infected person coughs or sneezes, or by saliva droplets or nose discharge. (Chan et al., 2020)Covering of mouth and nose with handkerchief, tissue or lexed elbow, especially during coughing or sneezing, and immediate disposal of the same after use.Periodic sanitization of hands by using an alcohol-based hand sanitizer which contains at least 70% v/v concentration of ethyl alcohol or isopropyl alcohol, or regular washing of hands with soap and water. ((EMRO), 2020)

Signs and Symptoms
Normally signs and symptoms of infection include shortness of breath, fever, and cough, and Dif iculties during breathing. In a more extreme situation, the infection can cause pneumonia, extreme acute respiratory syndrome, kidney failure, and maybe death.
According to the National Health Service and World Health Organization, signs and symptoms include: • Feeling tired and sleepy

Treatment
There is presently no particular vaccine or treatment available for COVID-19 infection and extreme cases, current treatment includes care to support vital organs functions. Various therapeutic choices including ribavirin, interferon alfa, and ritonavir or lopinavir are given in combination. Interferons with ribavirin give a de ined effect on coronavirus infection. In the other way therapies with antibody and plasma obtained from the convalescent patient, cases have recommended as a treatment. Controlling and identifying the source of infection, early diagnosis, identi ication, isolation, supportive remedies or treatments is the correct way to deal with extreme infections of coronavirus and timely reporting epidemic information to keep away from needless panic. For all human beings, good personal hygiene itted masks, good ventilation and distancing away from crowded places will support to prevent coronavirus infection. (Al-Osail and Al-Wazzah,

Prevention recommended by WHO for the general public
WHO provides the following standard recommendations protocols for the common people to reduce the exposure and contain the infections, which mainly includes hand and respiratory hygiene, and safe food intake and delivery practices:Periodic sanitization of hands by using an alcohol-based hand sanitizer which contains at least 70% v/v concentration of ethyl alcohol or isopropyl alcohol, or regular washing of hands with soap and water for considerable amount of time.
Periodic sanitization of hands by using an alcoholbased hand sanitizer which contains at least 70% v/v concentration of ethyl alcohol or isopropyl alcohol, or regular washing of hands with soap and water for considerable amount of time.
Covering of mouth and nose with handkerchief, tissue or lexed elbow, especially during coughing or sneezing, and immediate disposal of the same after use.
Maintenance of social distancing norms as instructed.
In case of cough, dif iculty in breathing and fever, healthcare provider must be contacted immediately and every detail of past travel history should be shared.
Raw food products or under cooked animal products should not be consumed. Milk, animal organs or raw meat should be handled carefully in order to protect cross-contamination with uncooked foods.
Strict maintenance of considerable distance from individuals having any signs and symptoms of respiratory infection like sneezing and coughing. ((DON), 2020), (Coronavirus, 2020)

COVID-19 and its effect on wealth in our global village
COVID-19 has adversely affected the economy of the entire globe. Poor are worst hit by it. This has been documented and predicted earlier. (Price-Smith, 2001) United Nations has suggested that the pandemics threaten national security, (Davies, 2020) and this has already been observed in past centuries. A pandemic like this takes the globe economically, socially, psychologically way beyond its present time. A comprehensive study which was carried out during 1950-1991 involving 20 countries which had all the three groups of nations including developed, developing and underdeveloped revealed that the increasing prevalence of infectious diseases not only increases human mortality and morbidity rate but also result in the gradual erosion of State capacity and increase in poverty. (Bank, 2020) This economic decline that is caused due to the covid-19 has a unproductive and viscious effect on autonomy, iscal resource, resilience, reach and responsiveness and legitimacy. There are various evidences showing that infectious diseases are heavy threat to national security and State power. The prevalence of infectious disease was found to cause a lot of dif iculties in the ability of the state to maintain the armed forces in positions and well nourished, which in turn possessed a question on State security. (Wilson, 2020) Many factories in People's Republic of China, Republic of Korea and certain other countries where the toll of COVID-19 patients is very high had to be locked down just within a month of onset of the outbreak. As the supply chain to other countries of various non essential goods was interrupted, PRC had to adversely reduce its industrial production, thus undermining trade and economics. The world tourism body had estimated the overall expenditure of world tourism to be nearly US$ 22,000 million, which was however not at all accomplished because of travel bans imposed. The pandemic have already ruined global stock exchange markets directly and indirectly as shown in Figure 1 due to shut down of factories and various businesses. COVID-19 pandemic has been declared as the biggest threat to the global economy by World Trade Organization (WTO) and the Organization for Economic Cooperation and Development (OECD) after the inancial crisis of 2008-2009. (Tandon, 2020 In case the impact on leading economies turns out to be as extreme because the disruptions suffered by means China, the OECD warns that world growth ought to even drop to 1.5 percentage in 2020, almost half the rate originally projected. The following Figure 2 shows the latest growth projections for the world's largest economies, in addition to the preceding forecast dating lower back to November 2019. (OECD, 2020)

CONCLUSIONS
In this review article, various types of coronaviruses that affect a wide variety of human and veterinary diseases have discussed. Coronaviruses are zoonotic pathogens with a high mutation rate which might be present in humans and many animals host cells and carry out their infection and replication. This article also includes signs and symptoms, origin, diagnostic method, treatment, prevention recommended by WHO and the impact of COVID-19 on global wealth. MERS-CoV and SARS-CoV can be transferred directly to humans from the dromedary camel required further studies. The latest methods of identi ication of viruses by RT-PCR assay was used to estimate viral RNA by targeting a consensus RDR pregion of pan -CoV. There is presently no particular vaccine or treatment available for COVID-19 infection and extreme cases, current treatment includes ribavirin, interferon alfa, and ritonavir or lopinavir are given in combination. Global stock exchange has a drop-down rapidly as stock investors continue to worry about the broader economic effects of the COVID-19. All over the world (04 July 2020) more than530,291people are dead and more than 11,260,677people are infected due to this deadly COVID-19 virus. 2020 showed the worst performance for the major stock market since the 2008-2009 inancial crises. We should conduct a continuous health education campaign about the awareness of COVID-19 and also provide the general guidelines & some basic information about symptoms, spreading patterns, mutation, infection, care and prevention of COVID-19.