The Bite-raised Condition in Aged SAMP8 Mice Reduces the Expression of Glucocorticoid Receptors in the Dorsal and Ventral Hippocampus

Yukiko ICHIHASHI; Naonori SAITO; Yoko ARAKAWA; Chika KURATA; Mitsuo IINUMA; Yasuo TAMURA; Fumihiko IWAKU; Kin-ya KUBO

doi:10.2535/ofaj.84.137

Yukiko ICHIHASHI, Naonori SAITO, Yoko ARAKAWA, Chika KURATA, Mitsuo IINUMA, Yasuo TAMURA, Fumihiko IWAKU, Kin-ya KUBO

Author information

Keywords: masticatory dysfunction, dorsal hippocampus, ventral hippocampus, glucocorticoid receptor, SAMP8 mice

JOURNAL FREE ACCESS

2008 Volume 84 Issue 4 Pages 137-142

DOI https://doi.org/10.2535/ofaj.84.137

Details

Abstract

In the present study, we examined whether the effects induced by the bite-raised condition on glucocorticoid receptor (GR) expression differ between the dorsal and ventral hippocampus in SAMP8 mice. In the bite-raised condition, the number of GR-immunoreactive cells was significantly decreased in both the dorsal and ventral CA1 and dentate gyrus (DG) subfields of the hippocampus compared to control mice, as revealed by immunohistochemical analysis. The decrease in the number of GR-immunoreactive cells tended to be greater in the dorsal hippocampus than in the ventral hippocampus. Only in the DG subfield was there a significant difference in the number of GR-immunoreactive cells between the dorsal and ventral hippocampus. These findings suggest that in aged SAMP8 mice, the bite-raised condition decreases the number of GR-immunoreactive cells in both the dorsal and ventral hippocampus.

Corresponding author

Register with J-STAGE for free!