HSOA Journal of Nephrology & Renal Therapy Case Calciphylaxis or Calcific Uremic Arteriolopathy: Diagnosis Not to be Overlooked in Hemodialysis Patients

TP 39%. An inflam matory syndrome with a CRP at 230 mg/l, a fibrinogen at 7g/l and a ferritinemia 400μg/l. phosphoremia Ca×P 6808mg²/dl²; parathormone 1-84 591pg/ml. The rereading of the biopsy reveals an infiltration of the of the and medium-sized by calcium deposits by and Von Kossa indicating the stopping of immu nosuppressants and AVK with regular skin care and daily dialysis by calcium concentration 1.25mmol/l. Abstract Calciphylaxis or calcific uremic arteriolopathy is a rare and se - vere condition due to its painful ischemic necrosis cutaneous and sometimes systemic lesions, whose functional and vital prognosis is reserved due to infectious complications. Several factors are impli -cated, but the physiopathology is not yet fully understood. Its treat - ment is poorly codified based mainly on a treatment of pain, tissue oxygenation, the release of calcium salts of vessels and the elimina - tion of factors and promoting drugs. We illustrate through a clinical case the essential points to recognize on this pathology.


Discussion
Calcifying uremic arteriolopathy "AUC" is a rare pathology, its incidence is variable according to the literature ranging from 0.04% according to the American register [1] and reaches 4% according to the Martinique register [2]. Many risk factors are raised, in particular diabetes, obesity and the female sex with an average age of 50 years, as well as the use of AVK, with presence of risk factor superadded in hemodialysis patients like hyperphosphoremia, seniority in dialysis> 10 years and VIT D and Ca supplementation treatments, martial supplementation or even corticotherapy-based treatments [3,4].
The pathogenesis of AUC remains poorly understood and incomplete since not all patients who have its risk factors will develop calciphylaxis lesions; nevertheless the process of systemic vascular Citation: Montasser DI, Issouani J, Belmajdoub G, Kabbaj D (2020) Calciphylaxis or Calcific Uremic Arteriolopathy: Diagnosis not to be Overlooked in Hemodialysis Patients. J Nephrol Renal Ther 6: 032. and soft tissue calcifications is responsible for the reduction of arteriolar blood flow with calcification and fibrosis and the formation of thrombi in the dermo-hypodermic arterioles with the installation of a state of hypercoagulability and tissue ischemia, associated with this mechanism the elevation of the phospho-calcic product incriminated as well as the hyperparathyroidism in the hemodialysis patients and the chronic inflammatory states which can also be responsible for the appearance of CUA as in the case of connectivites "crohn, auto disease -immune "or neoplastic disorders reported by certain publications [5][6][7].
The diagnosis must be urgent. The clinic is dominated by lesions of livedo, ulcers or necrotic plaques of locations often distal as in our patient who had lesions in the leg and heel, or proximal or in the fatty areas (trunk, abdomen) [7]. It can pose a problem of differential diagnosis with cholesterol embolism, anti-phospholipid syndrome, anti-vitamin k necrosis, bullous dermatitis, ocher ulcer of venous insufficiency and nephrogenic systemic fibrosis [8].
The treatment is less well codified but the most specific treatment used in the first intention is sodium thiosulfate with a dose adapted to renal function from 12.5 to 25mg/day without exceeding 2.5mg/kg which allows dissociation of the salts calcium with antioxidant effect and local vasodilation [9].
The treatment is also based on hemodialysis patients on the reduction of the calcium-phsphorus product and the correction of risk factors by the use of baths low in calcium 1.25mmol/l as well as the non-calcium phosphorus chelators "sevelamer carbonate or lanthanum carbonate and the use of calcimimetic "cinacalcet" for treatment of PHT and avoiding low blood pressure.
Martial therapy should be discontinued in dialysis patients.
If despite the therapeutic measures and beyond 3 months the patient is declared in therapeutic failure and resistant to treatment with indication of hyperbaric oxygen therapy, some writings recommend the use of biphosphonates if treatment failure [10].
This treatment can be accompanied by local treatment of necrosis by surgical debridement and dressing with MEOPA. Other treatments are being tested such as plasminogen activators and treatment with green larvae of the "lucilia sericata" fly or the rheopherae [11].
The life prognosis is poor (60 to 80% of mortality) given the high risk of systemic infection linked to skin lesions [6]; increased by the female sex 59%, the advanced stage of renal failure, insulin-dependent diabetes, obesity as well as the potential deleterious effect of AVK and insulin injections aggravating the lesions as in our patient associated with disturbances phosphocalcic balance such as hypercalcemia, hyperphosphoremia, hyperparathyoidism and hypervitaminosis D.

Conclusion
AUC is a thrombotic cutaneous microangiopathy responsible for ischemia phenomena and particularly painful skin necrosis of dialysis patients. Several factors are incriminated, mainly obesity, diabetes, female gender, AVK, elevated phosphocalcic product, hyperparathyroidism, overdoses of calcium and vitamin supplements, and chronic inflammatory phenomena. The treatment consists in quickly restoring a normal phospho-calcium balance. The vital prognosis is often engaged.
No conflicts of interest.