A Clinicoepidemiological Study Of Psoriasis And Its Association With Metabolic Syndrome

Background: Psoriasis is an immune-mediated inflammatory disease, characterized by epidermal hyper-proliferation, abnormal keratinocyte differentiation, angiogenesis, vasodilatation and excess Th1/Th17 mediated inflammation,& affects 2-3% of the population worldwide. Recently, many literatures have shown its association with metabolic syndrome Aim: To study the epidemiological aspect and its association with metabolic syndrome Study Design: The epidemiological part was done as a cross-sectional study and association was seen by performing a case control study Materials and Methods: After obtaining approval from institutional ethical committee, all diagnosed cases of psoriasis in outpatient department of dermatology of our college were included for epidemiological study. All cases were subjected to detailed history. Of these 150 new cases who had not taken any treatment in the past 6 months were selected. After obtaining written informed consent 150 cases were confirmed by biopsy and further investigated to see the association with metabolic syndrome. Also, 150 age and sex matched controls from general population (e.g. attendants, hospital staffs and colleagues ) were similarly investigated. The severity of the disease among cases was assessed using PASI scoring. Statistical Method: Results for continuous parameters are presented as mean ± SD and for categorical parameters as percentage. Significance is assessed at 5% level of significance. ANOVA has been used for comparing three or more groups, Chi square and /T test for comparing two or more groups Result: Out of 150 psoriasis patients, 18% were diabetic as compared to 14% controls,14% cases had hypertension in comparison to 15.33% of controls, both data being insignificant and hyperlipidemia though seen in a good number of patients of psoriasis was not statically significant. Conclusion: Though, there are plenty of reports from west approving association of psoriasis and metabolic syndrome it can be explained on the basis of increased prevalence of obesity, abnormal BMI and hypertension in westerners as compared to Indian patients and our study refuted any such association

The term "Psoriasis" embraces a spectrum of diseases ranging from localized plaques to more severe generalized involvement, with or without psoriatic arthritis and other autoimmune diseases.
Psoriasis predominantly affects the skin with erythematous plaques and adherent silvery white scales involving mainly the extensor surfaces of the body like scalp, back, elbows, knees etc. Chronic plaque psoriasis is the most common morphological form with localized and generalized pustular forms less commonly seen.

Types of psoriasis:
Two clinical presentations of psoriasis, type I and II, are distinguished by a bimodal age at onset. Type 1 begins on or before age 40 years; Type II begins after the age of 40 years. Type I disease accounts for more than 75% of cases [7].

Co-morbidities in psoriasis
Recently, a number of co-morbidities have been described in psoriasis patients, including cardiovascular co-morbidities, metabolic syndrome and malignancies [8,9]. Hypertension, heart failure and diabetes mellitus have been found to be more common among psoriasis patients [9].
Metabolic Syndrome(MS), defined as a cluster of risk factors including central obesity, atherogenic dyslipidemia, hypertension and glucose intolerance, is a strong predictor of cardiovascular disease, that confers a cardiovascular risk higher than the individual components.
The chronically high levels of free fatty acids associated with both metabolic syndrome and psoriasis may lead to adipocyte dysfunction and inhibit insulin secretion, and also induce apoptosis of pancreatic b-islet cells through an endoplasmic stress response leading to the development of type 2 diabetes [10].
Psoriasis is associated with MS, independent of its severity [11].
It has been seen that the chronic and systemic Th-1-and Th-17-mediated inflammation of psoriasis characterized by increased levels of pro-inflammatory cytokines, e.g. tumor necrosis factor-α and interleukin-6,that not only promotes epidermal hyperplasia in psoriasis, but also antagonizes insulin signaling, alters adipokine expression, and mediates insulin resistance and obesity [3,12]. Furthermore,Obesity is associated with severe psoriasis and is reported about twice as frequently among psoriasis patients as in the general population.The association between psoriasis and metabolic syndrome is also true for mild severity psoriasis and is independent from the tendency of psoriatic patients to be obese [11].
The combined dysfunction of leptin, adiponectin, resist in, and visfatin described in psoriasis may account for the development of metabolic syndrome and other conditions associated with atherosclerosis seen in patients with psoriasis [13,14].
Recent studies have estimated prevalence of MS to be 15-24% in the general population and 30-50% among psoriasis patients.
This increased frequency imposes a substantial burden on the overall health of psoriasis patients, which needs to be appropriately addressed during treatment of such patients.
Though, many foreign studies on association of MS with psoriasis has recently been done , but such Indian studies are still lacking.
Further, dermatologists taking care of psoriasis should know about such associations of diabetes and hypertension with psoriasis so that they can advise them regarding risk factors and about how to reduce them.
The present study has been undertaken to study association of psoriasis with various components of metabolicsyndrome and PASI.

Source of data
The study comprised of cases of psoriasis visiting outpatient department of dermatology of Patna medical college, Patna, Bihar.

Methodology and type of data collected:
After obtaining clearance and approval from institutional ethical committee, all diagnosed cases of psoriasis in outpatient department of dermatology of Patna Medical College were included for epidemiological study.
All cases were subjected to detailed history including demographic data, drug history, personal history and family history,past and present medical history and drug intake as per the proforma attached in the Annexure1. Demographic and drug intake data was collected. Cases were also classified based on their occupational status.
Out of 372 patients fulfilling above criteria, after obtaining written informed consent 150 cases were confirmed by biopsy and further investigated to see the association with metabolic syndrome. Also, 150 age and sex matched individuals from general population (eg., attendants, hospital staffs and colleagues) were similarly investigated.
The severity of the disease among cases was assessed using PASI scoring and patient divided into mild(<3), moderate (3-10) and severe(>10). Waist circumference was measured by locating the uppermost part of hip bone and placing a measuring tape around abdomen ,tight enough but without compressing the skin, and keeping it horizontal. Blood pressure was recorded as an average of two measurements, taken 5 minutes apart after the subjects had been at rest for 10 minutes. A 5ml venous blood sample was collected from both cases and controls, after overnight fasting (8 hours fast) and sent for laboratory biochemical estimations.

PASI
PASI scoring was done using following formula: E=Erythema, I=Induration, D=Desquamation,h=Head,u=Upper limb,t=Trunk, l=Lowerlimb The scores can vary from 1-72 in steps of 0.1.

In our study:
PASI :< 3 was graded as MILD 3-10 was graded as MODERATE >10 was graded as SEVERE

Statistical analysis
Results for continuous parameters are presented as mean ± SD and for categorical parameters as percentage. Significance is assessed at 5% level of significance&Chi square and /T test have been used for comparing two or more groups (Graphs 1-5). The stastical analysis software epiinfo 7 was used to analyse the data (Tables 1-6).  Table 4: Lipid profile among cases and controls.    shown relationship between abnormal glucose tolerance and psoriasis [15].

Discussion
Also, an Indian study by Alexander et al. revealed a prevalence of diabetes in 13.1% of psoriasis patients [16].
Yet another study done by, Madanagobalane S et al., found an association between hyperglycemia and psoriasis [17].
However, western studies show more consistent results with significant association of diabetes with psoriasis seen in most of them. Lonnberg et al. found a significant association between psoriasis and type 2 diabetes mellitus (odds ratio [OR], 1.53; 95% CI, 1.03-2.27; P = .04) [22].
In our study as inferred from tables 1 & 6, metabolic syndrome was not associated with psoriasis disease and severity and consistent with our study, Nisa and Qazi reported that PASI>10 was more common in patients without metabolic syndrome (P>0.050) and also Shankar U, et al. and Lakshmi S, et al. did not show any association of diabetes with psoriasis [23,24].

Association with hypertension
As shown in Table 2 prevalence of hypertension in cases of psoriasis was 13.33% as compared to in 15.33% controls which was consistent with that of an Indian study by Alexander, et al. which revealed a prevalence of hypertension in only 8.1% of psoriasis patients. This however was in contrast to a study done by Alexander E, et al. Pinto J, et al. Pal GS, et al. [16].
Cohen, et al. in their study reported that the prevalence of hypertension was significantly higher in psoriasis patients than controls (38.8%, 29.1% respectively). Similar results were noted by Sommer, et al [19,20]. Thus, there was no significant increase in prevalence of hypertension in patients with psoriasis (p value: 0.741).

Association with lipid parameters
According to table 4. 50.67% of the cases had serum triglycerides within the normal range as compared to 59.3% of the controls and according to table 6 the mean value in cases was 179.81 which was nearly equal to the mean value in controls which was 176. (p val-ue=0.732). Table 4 shows.66.67% of the cases had serum HDL within the normal range as compared to 62 of the controls. Thus, no significant difference in HDL values was seen in cases and controls (p value0.399). Similarly, Madanagobalane S, et al. and Anandan S, et al. did not find any significant association of raised HDL and hypertension with psoriasis [17].  [26].
In a chinese study no association was found between Serum levels of triglyceride and LDL and psoriasis [27].
Even in a recent study done by Kothiwala SK, Khanna N, Tandon N, et al. no correlation was seen between Sr HDL and Sr TG and psoriasis [28].
There was a uniformly higher prevalence of all components of metabolic syndrome in men and women with psoriasis compared with those without across all age groups in a study done by Danielsen K, Wilsgaard T, Olsen AO, Eggen AE, Olsen K, Cassano PA, Furberg AS et al. [29] In our study as evident from table 3, prevalence of obesity among cases was 17.33% and 13.33% among controls so, there was no association between obesity and psoriasis (p value=0.153).  In contrast Madanagobalane and Anandan, reported a higher prevalence of obesity in psoriasis patients than in controls [17] Summary • While comparing 150 age and sex matched cases and controls,17.33% cases as compared to 14% controls had hyperglycemia which may be due to most common age group affected being 41-50 years, which is also common age group for onset of diabetes It may be due to the fact that most of rural population of India especially Bihar are not capable enough of consuming fat rich meals, do a lot of manual work and involved in many rigorous activities.
Our study, clearly refuted any association of psoriasis with metabolic syndrome in Indian patients. The plenty of reports from west approving such an association can be explained on the basis of increased prevalence of obesity, abnormal BMI and hypertension in westerners as compared to Indian patients. In addition, there is also higher prevalence of coexistent risk factors like smoking and alcohol intake in the west which may contribute to the morbidity and prevalence of metabolic syndrome. Further most such studies have been conducted on patients on treatment while our study has been done on newly diagnosed patients prior to the initiation of any therapy.
Looking at various studies around the world, which included population samples, aged from 20 to 25 and upwards, the prevalence of metabolic syndrome in healthy adults varies from 8% in India to 24% in United States in men. This goes on to prove that there are additional metabolic and risk factors that contribute to the increased prevalence of metabolic syndrome in western patients.
This has important implications for treating dermatologist as it allows them to be more adventurous and aggressive in treating these patients while simultaneously saving the cost of expensive unnecessary investigations that they may resort to rule out underlying metabolic syndrome.