with Ulcerative Colitis at Dr . Saiful Anwar Malang General Hospital

Background: The prevalence ulcerative colitis (UC) in RSCM Jakarta in 1991-1995 is 2.5%. The disease affects men and women at similar rates or slightly more common in women than in men. Age of onset follows a bimodal pattern, with a peak at 15-25 years and a smaller one at 55-65 years, although the disease can occur in people of any age. The precise etiology of UC is not well understood. UC is precipitated by a complex in Dr. Saiful Anwar General Hospital Malang. Method: This is a retrospective survey analysis from medical record which was taken from 2170 patients who underwent colonoscopy in Dr. Saiful Anwar General Hospital Malang from January 2010 to December 2014. Demographic setting (sex, age), clinical features, lifestyle, diagnosis based on colonoscopy were analyzed as the variables. Results: Total patients with UC was 176 patients. The prevalence of UC during 2010-2014 was 8.2% at Dr. Saiful Anwar General Hospital. There was a similar prevalence of sex between male and female patients, in which 95 (53.4%) were male and 81 (46.6%) were female. The average age of patients with UC was 41,6 years. Most patients were presented with abdominal pain (32.90%) and weight loss (42.1%). The diagnosis based on colonoscopy were pancolitis (36%), proctosigmoiditis/proctitis (31.81%), and left-sided colitis (21.9%). The risk Majority of ulcerative colitis study samples were non-smoker (75%), not consuming herbal treatment/NSAID diet and UC (r = -0.106, p = 0.000). Conclusion: average age was 41.6 years. Patients presented with various clinical symptoms, most are abdominal pain and


INTRODUCTION
Ulcerative colitis (UC) is considered frequent in majority of European and North American population but at the end of the decade of the 90s and into the 21 st century, there is a tendency of increasing incidence in the 6 The prevalence ulcerative colitis in Dr. Cipto Mangunkusumo Hospital Jakarta in 1991-1995 is 2.5%. 1 The disease affects men and women at similar rates or slightly more common in women than in men.Age of onset follows a bimodal pattern, with a peak at 15-25 years and a smaller one at 55-65 years, although the disease can occur in people of any age. 6ased on the study of Olmsted, the average age of patients diagnosed with UC age of 34.9 years. 13he precise etiology of UC is not well understood.It is generally estimated that the pathogenesis of UC preceded by an infection, toxins, diet product or intraluminal colonic bacteria, which occur in susceptible defects, the environment (cigarretes, diet, NSAID, etc), wall. 1 The aim of this study is to identify the prevalence, Anwar General Hospital Malang.

METHOD
We collect medical records from January 2010 to December 2014, all patients who underwent for colonoscopy at Dr. Saiful Anwar General Hospital Malang include in this study.Diagnosed of ulcerative colitis was from colonoscopy.To assess prevalence, risk the following data were recorded for each subject: age, gender, clinical feature (type of defecation, abdominal pain, decrease of body weight, conjunctiva anemic), disease location, consumption of traditional herbs/ were categorized for data analyses.
This study was retrospective survey analysis.The between the rate of UC and clinical characteristics.

RESULTS
From total of 2170 patients which underwent colonoscopy, total patients with UC was 176 patients.The prevalence of UC since 2010-2014 was 8.2% at our hospital.According to the lifestyle, of the total 176 patients UC only 25% were smokers, 75% were non-smoker.One hundred and six (60.22%)UC patients were not proctosigmoid/proctitisas many as 56 (31.8%), the left-sided colitis as many as 39 (21,9%), the colon ascenden as many as 4 (2.2%), the rectosigmoid and colon ascenden as many as 3 (1.7%), the caecum as many as 3 (1.7%), the colon transversum with ascenden and caecum as many as 3 (1.7%), the proctitis with caecum as many as 2 (1.1%), in the ileo-caecal as many as 1 (0.6%), in the terminal ileum as many as 1 (0.6%).

DISCUSSION
This study demonstrated that the prevalence of ulcerative colitis at Dr. Saiful Anwar General Hospital Malang since 2010-2014 was 8.2%.This prevalence was higher than that reported by Dr. Cipto Mangunkusumo Hospital Jakarta in 1991-1995, which was 2.5%.It may indicate the increasing of risk factors like industrian or western diet and lifestyle or an increasing number of susceptibility genes that have bowel disease. 13In our study disease prevalence was high in patients between 46-55 years of age, males and females were equally affected which is in line with those reported by Langan et al which reported UC to be most common in 15 and 40 years of age, with second peak of incidence between 50 and 80 years. 23he rectum is involved in more than 95% of cases, but in our study the most disease manifestation was pancolitis (35.4%), this is because most of patients who came already in advanced state, which is characterized by abdominal pain (71.7%), weight loss (42.1%), and chronic diarrhea with bloody and mucous (22.15%). 6,19e tried to explore the relationship between each risk factor that affects the UC incidence.Variable that we use was smoking, the use of herbal medicine or NSAID for smoking or use of herbal medicine or NSAID in the frequency different between non-UC with UC patient.We continued our statistical analysis for this variable and UC incidence (r = -0.106;p = 0.000).
Despite its contributions, this study had certain limitation.First, the design of our study was restrocpective study, and the second was, the data that we collected was a secondary data from the physician, the third limitation of the study is the quality that made that we lost some data for each individual (hemoglobin level, albumin level, and risk factors).

CONCLUSION
The prevalence of UC in our hospital was higher than that reported by Dr. Cipto Mangunkusumo Hospital Jakarta in 1991-1995.Our results showed

Table 1 . Clinical characteristics of patients ulcerative colitis at Saiful Anwar General Hospital from 2010-2014
The Prevalence, Profile, and Risk Factor of Patients with Ulcerative Colitis at Dr. Saiful Anwar Malang General Hospital