Evaluation of the memory CD4+ and CD8+ T cells homeostasis during chronic venous disease of lower limbs.

Dominika Ojdana; Kamil Safiejko; Robert Milewski; Paweł Sacha; Piotr Wieczorek; Alina Lipska; Piotr Radziwon; Jacek Dadan; Elzbieta Tryniszewska

doi:10.2478/v10042-009-0081-4

Vol 47, No 3 (2009)

Original paper

Submitted: 2011-12-19

Published online: 2010-02-19

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Evaluation of the memory CD4+ and CD8+ T cells homeostasis during chronic venous disease of lower limbs.

Dominika Ojdana, Kamil Safiejko, Robert Milewski, Paweł Sacha, Piotr Wieczorek, Alina Lipska, Piotr Radziwon, Jacek Dadan, Elzbieta Tryniszewska

DOI: 10.2478/v10042-009-0081-4

Folia Histochem Cytobiol 2009;47(3):471-477.

Vol 47, No 3 (2009)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2010-02-19

Abstract

More and more is known about the role of venous wall abnormalities and valvular incompetence in the development of chronic venous disorders (CVD). Unfortunately detailed mechanisms of CVD pathophysiology are not well understood. Recent studies focus on involvement of the inflammatory process in the structural remodeling of venous valves and venous wall. The aim of this study is to investigate and to document the memory T cells homeostasis in CVD patients. In this study we present lymphocytic changes in blood from varicose veins in terms of total CD4+ and CD8+ T cells and their particular subsets of memory T cells: TN, TCM and TEM. Results suggest that immunological memory may be involved in the CVD development.