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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access June 29, 2014

Green coffee as a novel agent for Alzheimer’s disease prevention by attenuating diabetes

  • Merina Varghese EMAIL logo , Lap Ho , Jun Wang , Wei Zhao , Samara Levine , Kenjiro Ono , Salvatore Mannino and Giulio Pasinetti

Abstract

Diabetes type 2, caused mainly by insulin resistance, is growing in incidence worldwide. In addition to being a major public health concern, type 2 diabetes is also a risk factor for dementia, including Alzheimer’s disease type dementia. Coffee consumption is reported to have protective effects in both diabetes and Alzheimer’s disease. We review here the reported beneficial effects of coffee in both disease conditions and the previously identified active ingredients of coffee. Furthermore, we revisit our recent findings of improved glucose utilization in the periphery and in the brain in a mouse model of high-fat diet induced type 2 diabetes after treatment with a decaffeinated green coffee preparation. Overall, consumption of coffee appears to improve diabetes and reduce the risk of dementia, although future studies are required to further identify the active components and the type of coffee that is most effective in addressing these conditions.

[1] International Diabetes Federation, IDF Diabetes Atlas, cited 2013 August 27, 5th Edition, 2012, available from: http://www.idf.org/diabetesatlas/5e/Update2012 Search in Google Scholar

[2] World Health Organization, Diabetes Fact Sheet, 1999, cited 2013 August 27, available from: http://www.who.int/mediacentre/factsheets/fs312/en/ Search in Google Scholar

[3] Alberti K. G., Zimmet P. Z., Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation, Diabet. Med., 1998, 15, 539–553 http://dx.doi.org/10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-SSearch in Google Scholar

[4] Vagelatos N. T., Eslick G. D., Type 2 diabetes as a risk factor for Alzheimer’s disease: the confounders, interactions, and neuropathology associated with this relationship, Epidemiol. Rev., 2013, 35, 152–160 http://dx.doi.org/10.1093/epirev/mxs01210.1093/epirev/mxs012Search in Google Scholar

[5] Alzheimer’s Association, 2013 Alzheimer’s disease facts and figures, cited 2013 August 27, available from: http://www.alz.org/downloads/facts_figures_2013.pdf Search in Google Scholar

[6] Butt M. S., Sultan M. T., Coffee and its consumption: benefits and risks, Crit. Rev. Food Sci. Nutr., 2011, 51, 363–373 http://dx.doi.org/10.1080/1040839090358641210.1080/10408390903586412Search in Google Scholar

[7] van Dam R. M., Hu F. B., Coffee consumption and risk of type 2 diabetes: a systematic review, JAMA, 2005, 294, 97–104 http://dx.doi.org/10.1001/jama.294.1.9710.1001/jama.294.1.97Search in Google Scholar

[8] Huxley R., Lee C. M., Barzi F., Timmermeister L., Czernichow S., Perkovic V., et al., Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis, Arch. Intern. Med., 2009, 169, 2053–2063 http://dx.doi.org/10.1001/archinternmed.2009.43910.1001/archinternmed.2009.439Search in Google Scholar

[9] Muley A., Muley P., Shah M., Coffee to reduce risk of type 2 diabetes? A systematic review, Curr. Diabetes Rev., 2012, 8, 162–168 http://dx.doi.org/10.2174/15733991280056401610.2174/157339912800564016Search in Google Scholar

[10] Reunanen A., Heliovaara M., Aho K., Coffee consumption and risk of type 2 diabetes mellitus, Lancet, 2003, 361, 702–703, author reply 703 http://dx.doi.org/10.1016/S0140-6736(03)12583-410.1016/S0140-6736(03)12583-4Search in Google Scholar

[11] Saremi A., Tulloch-Reid M., Knowler W. C., Coffee consumption and the incidence of type 2 diabetes, Diabetes Care, 2003, 26, 2211–2212 http://dx.doi.org/10.2337/diacare.26.7.221110.2337/diacare.26.7.2211Search in Google Scholar

[12] Floegel A., Pischon T., Bergmann M. M., Teucher B., Kaaks R., Boeing H., Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) — Germany study, Am. J. Clin. Nutr., 2012, 95, 901–908 http://dx.doi.org/10.3945/ajcn.111.02364810.3945/ajcn.111.023648Search in Google Scholar

[13] Pereira M. A., Parker E. D., Folsom A. R., Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women, Arch. Intern. Med., 2006, 166, 1311–1316 http://dx.doi.org/10.1001/archinte.166.12.131110.1001/archinte.166.12.1311Search in Google Scholar

[14] van Dam R. M., Willett W. C., Manson J. E., Hu F. B., Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women, Diabetes Care, 2006, 29, 398–403 http://dx.doi.org/10.2337/diacare.29.02.06.dc05-151210.2337/diacare.29.02.06.dc05-1512Search in Google Scholar PubMed

[15] Robinson L. E., Savani S., Battram D. S., McLaren D. H., Sathasivam P., Graham T. E., Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes, J. Nutr., 2004, 134, 2528–2533 10.1093/jn/134.10.2528Search in Google Scholar PubMed

[16] Kogure A., Sakane N., Takakura Y., Umekawa T., Yoshioka K., Nishino H., et al., Effects of caffeine on the uncoupling protein family in obese yellow KK mice, Clin. Exp. Pharmacol. Physiol., 2002, 29, 391–394 http://dx.doi.org/10.1046/j.1440-1681.2002.03675.x10.1046/j.1440-1681.2002.03675.xSearch in Google Scholar PubMed

[17] Yoshioka K., Yoshida T., Kamanaru K., Hiraoka N., Kondo M., (1990). Caffeine activates brown adipose tissue thermogenesis and metabolic rate in mice, J. Nutr. Sci. Vitaminol. (Tokyo), 1990, 36, 173–178 http://dx.doi.org/10.3177/jnsv.36.17310.3177/jnsv.36.173Search in Google Scholar PubMed

[18] Welsch C. A., Lachance P. A., Wasserman B. P., Dietary phenolic compounds: inhibition of Na+-dependent D-glucose uptake in rat intestinal brush border membrane vesicles, J. Nutr. 1989, 119, 1698–1704 10.1093/jn/119.11.1698Search in Google Scholar PubMed

[19] Hemmerle H., Burger H. J., Below P., Schubert G., Rippel R., Schindler P. W., et al., Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase, J. Med. Chem., 1997, 40, 137–145 http://dx.doi.org/10.1021/jm960736010.1021/jm9607360Search in Google Scholar PubMed

[20] Prabhakar P. K., Doble M., Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes, Phytomedicine, 2009, 16, 1119–1126 http://dx.doi.org/10.1016/j.phymed.2009.05.02110.1016/j.phymed.2009.05.021Search in Google Scholar PubMed

[21] Lee K. J., Jeong H. G., Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage, Toxicol. Lett., 2007, 173, 80–87 http://dx.doi.org/10.1016/j.toxlet.2007.06.00810.1016/j.toxlet.2007.06.008Search in Google Scholar PubMed

[22] Bakuradze T., Lang R., Hofmann T., Stiebitz H., Bytof G., Lantz I., et al., Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines, Mol. Nutr. Food Res., 2010, 54, 1734–1743 http://dx.doi.org/10.1002/mnfr.20100014710.1002/mnfr.201000147Search in Google Scholar PubMed

[23] Hu N., Yu J. T., Tan L., Wang Y. L., Sun L., Nutrition and the risk of Alzheimer’s disease, Biomed. Res. Int., 2013, 524820 10.1155/2013/524820Search in Google Scholar PubMed PubMed Central

[24] Barranco Quintana J. L., Allam M. F., Del Castillo A. S., Navajas R. F. C., Alzheimer’s disease and coffee: a quantitative review, Neurol. Res., 2007, 29, 91–95 http://dx.doi.org/10.1179/174313206X15254610.1179/174313206X152546Search in Google Scholar PubMed

[25] Lindsay J., Laurin D., Verreault R., Hebert R., Helliwell B., Hill G. B., et al., Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian Study of Health and Aging, Am. J. Epidemiol., 2002, 156, 445–453 http://dx.doi.org/10.1093/aje/kwf07410.1093/aje/kwf074Search in Google Scholar PubMed

[26] Eskelinen M. H., Ngandu T., Tuomilehto J., Soininen H., Kivipelto M., Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study, J. Alzheimers Dis., 2009, 16, 85–91 10.3233/JAD-2009-0920Search in Google Scholar PubMed

[27] Cao C., Loewenstein D. A., Lin X., Zhang C., Wang L., Duara R., et al., High blood caffeine levels in MCI linked to lack of progression to dementia, J. Alzheimers Dis., 2012, 30, 559–572 10.3233/JAD-2012-111781Search in Google Scholar PubMed PubMed Central

[28] Cao C., Wang L., Lin X., Mamcarz M., Zhang C., Bai G., et al., Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer’s mice, J. Alzheimers Dis., 2011, 25, 323–335 10.3233/JAD-2011-110110Search in Google Scholar PubMed

[29] Gelber R. P., Petrovitch H., Masaki K. H., Ross G. W., White L. R., Coffee intake in midlife and risk of dementia and its neuropathologic correlates, J. Alzheimers Dis., 2011, 23, 607–615 10.3233/JAD-2010-101428Search in Google Scholar PubMed PubMed Central

[30] Chu Y. F., Chang W. H., Black R. M., Liu J. R., Sompol P., Chen Y., et al., Crude caffeine reduces memory impairment and amyloid beta(1–42) levels in an Alzheimer’s mouse model, Food Chem., 2012, 135, 2095–2102 http://dx.doi.org/10.1016/j.foodchem.2012.04.14810.1016/j.foodchem.2012.04.148Search in Google Scholar PubMed

[31] Cao C., Cirrito J. R., Lin X., Wang L., Verges D. K., Dickson A., et al., Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer’s disease transgenic mice, J. Alzheimers Dis., 2009, 17, 681–697 10.3233/JAD-2009-1071Search in Google Scholar PubMed PubMed Central

[32] Arendash G. W., Mori T., Cao C., Mamcarz M., Runfeldt M., Dickson A., et al., Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer’s disease mice, J. Alzheimers Dis., 2009, 17, 661–680 10.3233/JAD-2009-1087Search in Google Scholar PubMed

[33] Arendash G. W., Schleif W., Rezai-Zadeh K., Jackson E. K., Zacharia L. C., Cracchiolo J. R., et al., Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain beta-amyloid production, Neuroscience, 2006, 142, 941–952 http://dx.doi.org/10.1016/j.neuroscience.2006.07.02110.1016/j.neuroscience.2006.07.021Search in Google Scholar PubMed

[34] Fredholm B. B., Battig K., Holmen J., Nehlig A., Zvartau E. E., Actions of caffeine in the brain with special reference to factors that contribute to its widespread use, Pharmacol. Rev., 1999, 51, 83–133 Search in Google Scholar

[35] Canas P. M., Porciuncula L. O., Cunha G. M., Silva C. G., Machado N. J., Oliveira J. M., et al., Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway, J. Neurosci., 2009, 29, 14741–14751 http://dx.doi.org/10.1523/JNEUROSCI.3728-09.200910.1523/JNEUROSCI.3728-09.2009Search in Google Scholar

[36] Angulo E., Casado V., Mallol J., Canela E. I., Vinals F., Ferrer I., et al., A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation, Brain Pathol., 2003, 13, 440–451 http://dx.doi.org/10.1111/j.1750-3639.2003.tb00475.x10.1111/j.1750-3639.2003.tb00475.xSearch in Google Scholar

[37] Dostal V., Roberts C. M., Link C. D., Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of betaamyloid peptide toxicity, Genetics, 2010, 186, 857–866 http://dx.doi.org/10.1534/genetics.110.12043610.1534/genetics.110.120436Search in Google Scholar

[38] Evans M. J., Scarpulla R. C., Interaction of nuclear factors with multiple sites in the somatic cytochrome c promoter. Characterization of upstream NRF-1, ATF, and intron Sp1 recognition sequences, J. Biol. Chem., 1989, 264, 14361–14368 10.1016/S0021-9258(18)71686-4Search in Google Scholar

[39] Trinh K., Andrews L., Krause J., Hanak T., Lee D., Gelb M., et al., Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson’s disease through an NRF2-dependent mechanism, J. Neurosci., 2010, 30, 5525–5532 http://dx.doi.org/10.1523/JNEUROSCI.4777-09.201010.1523/JNEUROSCI.4777-09.2010Search in Google Scholar PubMed PubMed Central

[40] Tohda C., Kuboyama T., Komatsu K., Search for natural products related to regeneration of the neuronal network, Neurosignals, 2005, 14, 34–45 http://dx.doi.org/10.1159/00008538410.1159/000085384Search in Google Scholar PubMed

[41] Kwon S. H., Lee H. K., Kim J. A., Hong S. I., Kim H. C., Jo T. H., et al., Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice, Eur. J. Pharmacol., 2010, 649, 210–217 http://dx.doi.org/10.1016/j.ejphar.2010.09.00110.1016/j.ejphar.2010.09.001Search in Google Scholar PubMed

[42] Cho E. S., Jang Y. J., Hwang M. K., Kang N. J., Lee K. W., Lee H. J., Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals, Mutat. Res., 2009, 661, 18–24 http://dx.doi.org/10.1016/j.mrfmmm.2008.10.02110.1016/j.mrfmmm.2008.10.021Search in Google Scholar PubMed

[43] Ho L., Varghese M., Wang J., Zhao W., Chen F., Knable L. A., et al., Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice, Nutr. Neurosci., 2012, 15, 37–45 http://dx.doi.org/10.1179/1476830511Y.000000002710.1179/1476830511Y.0000000027Search in Google Scholar PubMed

[44] Ho L., Qin W., Pompl P. N., Xiang Z., Wang J., Zhao Z., et al., Dietinduced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease, FASEB J., 2004, 18, 902–909 10.1096/fj.03-0978fjeSearch in Google Scholar PubMed

Published Online: 2014-6-29
Published in Print: 2014-6-1

© 2014 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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