Uptake of the World Health Organization’s trauma care guidelines: a systematic review

Abstract Objective To understand the degree to which the trauma care guidelines released by the World Health Organization (WHO) between 2004 and 2009 have been used, and to identify priorities for the future implementation and dissemination of such guidelines. Methods We conducted a systematic review, across 19 databases, in which the titles of the three sets of guidelines – Guidelines for essential trauma care, Prehospital trauma care systems and Guidelines for trauma quality improvement programmes – were used as the search terms. Results were validated via citation analysis and expert consultation. Two authors independently reviewed each record of the guidelines’ implementation. Findings We identified 578 records that provided evidence of dissemination of WHO trauma care guidelines and 101 information sources that together described 140 implementation events. Implementation evidence could be found for 51 countries – 14 (40%) of the 35 low-income countries, 15 (32%) of the 47 lower-middle income, 15 (28%) of the 53 upper-middle-income and 7 (12%) of the 59 high-income. Of the 140 implementations, 63 (45%) could be categorized as needs assessments, 38 (27%) as endorsements by stakeholders, 20 (14%) as incorporations into policy and 19 (14%) as educational interventions. Conclusion Although WHO’s trauma care guidelines have been widely implemented, no evidence was identified of their implementation in 143 countries. More serial needs assessments for the ongoing monitoring of capacity for trauma care in health systems and more incorporation of the guidelines into both the formal education of health-care providers and health policy are needed.


Introduction
As a result of the unsafe conditions and the relatively poor outcomes once someone is injured in low-and middle-income countries, about 90% of the global burden of injury-related mortality and disability is found in low-and middle-income countries. 1 The likelihood of death after injury is up to sixfold greater in a low-and middle-income country than in a high-income country. 2 This disparity can be partially attributed to the relatively poor quality of trauma care in low-and middle-income countries -a problem often exacerbated by poor levels of development, organization and planning and a scarcity of programmes for the improvement of trauma care. The development of dedicated systems of trauma care, such as those to be found increasingly often in high-income countries, can improve outcomes after injury. [3][4][5][6][7] The World Health Organization (WHO) has made a concerted effort to address geographical inequalities in trauma care, especially via the development of the Essential Trauma Care Project and the publication of three sets of guidelines. These guidelines -entitled Guidelines for essential trauma care, Prehospital trauma care systems, and Guidelines for trauma quality improvement programmes -were published in 2004, 2005 and 2009, respectively, following consultations with dozens of organizations and hundreds of experts. [8][9][10][11] Together, these guidelines represent the best of the otherwise very limited guidance available to policy-makers and clinicians, in countries at all economic levels, who are seeking ways to strengthen systems for trauma care. Implementation of these guidelines reflects, at least in part, the status of trauma care globally.
For guidelines, publication does not always translate into application or implementation. 12 Although WHO publishes dozens of sets of guidelines every year, 13 the dissemination and implementation of any set of WHO guidelines are rarely investigated in detail. [14][15][16] Each of the sets of guidelines on trauma care that WHO published between 2004 and 2009 was mailed to 2000-3000 recipients -including many public libraries and WHO country offices -and several country offices hosted meetings to facilitate dissemination of the guidelines. However, we know very little about the subsequent use of the guidelines and we therefore conducted an Internet-based search for published articles and grey literature on this topic. By so doing, we hoped to identify gaps in use of the guidelines that need to be addressed and obtain a meta-synthesis of experiences with the guidelines that could help promote improvements in trauma care globally. In the broader context, we also sought to expand the knowledge base regarding the dissemination outcomes and implementation strategies for WHO guidelines in general.

Methods
The registered protocol for this systematic review (PROS-PERO: CRD42014010749) was drafted in accordance with Preferred reporting items for systematic reviews and meta-Objective To understand the degree to which the trauma care guidelines released by the World Health Organization (WHO) between 2004 and 2009 have been used, and to identify priorities for the future implementation and dissemination of such guidelines. Methods We conducted a systematic review, across 19 databases, in which the titles of the three sets of guidelines -Guidelines for essential trauma care, Prehospital trauma care systems and Guidelines for trauma quality improvement programmes -were used as the search terms. Results were validated via citation analysis and expert consultation. Two authors independently reviewed each record of the guidelines' implementation. Findings We identified 578 records that provided evidence of dissemination of WHO trauma care guidelines and 101 information sources that together described 140 implementation events. Implementation evidence could be found for 51 countries -14 (40%) of the 35 lowincome countries, 15 (32%) of the 47 lower-middle income, 15 (28%) of the 53 upper-middle-income and 7 (12%) of the 59 high-income. Of the 140 implementations, 63 (45%) could be categorized as needs assessments, 38 (27%) as endorsements by stakeholders, 20 (14%) as incorporations into policy and 19 (14%) as educational interventions. Conclusion Although WHO's trauma care guidelines have been widely implemented, no evidence was identified of their implementation in 143 countries. More serial needs assessments for the ongoing monitoring of capacity for trauma care in health systems and more incorporation of the guidelines into both the formal education of health-care providers and health policy are needed.
analyses (PRISMA) guidelines. 17 We used the titles of the three sets of WHO guidelines of interest -"Guidelines for essential trauma care", "Guidelines for trauma quality improvement programmes" and "Prehospital trauma care systems" -as our search terms. Phrase, verbatim or full-text searches were conducted where possible. Searches were restricted only by date, searching only after the date of publication of the guideline used as the search term. Articles published in Arabic, Chinese, English, French, Portuguese, Russian, Spanish or Vietnamese -i.e. the languages into which any of the three sets of the guidelines is known to have been translated -were eligible for inclusion in our review. A comprehensive search of both published and grey literature was conducted within the CINAHL, Cochrane, Embase, Global Health Database, Global Health Library -Regional Indexes, Google, Google Scholar, Grey Literature Report, OAIster, Open-Grey, ProQuest Conference Papers Index, ProQuest Dissertation and Theses, PubMed, SciELO, Scopus, Web of Science, WHO International Clinical Trials Registry Platform Search Portal, WHO LIS and WorldCat databases. We then contacted 20 experts in the fieldi.e. the most frequently cited authors in the articles that we considered to be of interest -and asked them to share any information they may have regarding implementation of the guidelines that was unpublished and/or not available online. Finally, we performed citation analysis, using Google Scholar, Scopus and Web of Science, to detect any additional relevant records that had been missed in the initial database searches.
Information sources were included in our review if they included evidence of the dissemination and/or implementation of at least one of the three sets of guidelines. Citation in an article of any information from a set of guidelinese.g. a statistic found in the guidelines -was considered to be evidence of the dissemination of that set of guidelines. Any reported application of a set of guidelines -e.g. use of the guidelines in needs assessments and/or educational initiatives -was taken as evidence of the implementation of the guidelines. Information sources that only referred to one or more of the sets of guidelines in the form of a link that readers might follow to access or purchase the guidelines were excluded. We included sources regard-less of their apparent quality. If two or more information sources described the same implementation event, only one of them was included in our data analysis. The search for relevant information sources was completed at the end of May 2015.
Two authors extracted data. One author performed the initial search, determined the eligibility of information sources for inclusion in the final analysis and determined which eligible sources provided evidence of implementation of the guidelines and which only gave evidence of the guidelines' dissemination. Sources providing evidence of dissemination were divided into those that advocated use of WHO guidelines and those that that merely made reference to such guidelines. Implementation was separated into four categories: (i) use of the guidelines for needs assessments, by the comparison of existing practices and resources with those recommended in the guidelines; (ii) the endorsement of the guidelines by national professional societies or other formal bodies; (iii) the use of the guidelines in educational interventions; and (iv) the incorporation of components of the guidelines into policy -as indicated by citation of the guidelines in an official regulatory document at an institutional, local or national government level. The same author also categorized each information source that documented implementation of WHO guidelines according to its type. The other author -chosen for his lack of involvement in trauma, quality improvement or WHO and his previous lack of a professional relationship with any of the other authors or advisorsthen reviewed the information sources that the first reviewer had classified as defining implementation and independently categorized any implementation. Discordance between the two authors was resolved through discussionsometimes following referral to a third author. Data were organized using Ref-Works reference management software (ProQuest, Ann Arbor, United States of America) and a simple database in Excel (Microsoft, Redmond, USA).
The study was conducted with the assistance of an advisory group that comprised a health-care librarian and five experts in trauma care, trauma quality improvement, WHO guideline formation and dissemination, and systematic review method.
Of the 19 descriptions of inclusion of the guidelines in the curriculum of an educational intervention, nine described continuing medical education for professionals, 37,63,[83][84][85]108,111,113,117 four described courses for lay firstresponders, 53,107,109 another four described education of postgraduate physicians in training, 40,86,88,112 and one the education of nursing students. 87 One reference described use of the guidelines to audit existing educational practices. 89 Only one of the educational interventions described inclusion of the WHO guidelines in degree requirements. 112 Approximately half of the eligible information sources were journal articles listed by PubMed and most of the remainder were from grey literature ( Table 4). Our analysis also included 13 implementation events that were Systematic reviews Use of WHO's trauma care guidelines Lacey LaGrone et al.
only reported directly to us, by the 20 experts in the field who we contacted. 46,47,50,52,59,[112][113][114][115][116][117] According to our analysis, at least one of the three sets of guidelines we investigated had been implemented in each of at least 51 countries -with evidence of implementation in 14 (40%) of the 35 low-income countries, 15 (32%) of the 47 lower-middle income, 15 (28%) of the 53 upper-middle-income and 7 (12%) of the 59 high-income. The location of several implementation events could only be identified as low-and middle-income countries, 21,68,104 Africa, 60,70,81 Europe, 18,67,69 Latin America 27,32 or, even more broadly, the Americas. 100,113 The number of implementation events re-corded per country varied, with more than 10 such events reported in each of five countries: Ghana, India, Mexico, South Africa and Viet Nam (Fig. 2). Almost all (134; 96%) of the 140 implementation events we included in our analysis had been reported in English. Of the 33 reports of implementation events in Latin America that we included, only three were in Spanish and only one was in Portuguese. Similarly, only two of the 16 reports of implementation events in Francophone countries that we included were in French.
Although the three sets of guidelines were specifically developed for lowand middle-income countries, at least one of the sets had been implemented in each of several high-income countries. In France, for example, the senate had adopted a draft bill to include training in first aid in the requirements for a driver's licence and that bill had made reference to Prehospital trauma care systems. 105

Discussion
When we planned this systematic review, our main aim was to determine the extent to which the WHO guidelines on trauma care were being used. The results of the review indicate fairly widespread implementation of the guidelines, with implementation events of various types documented in 51 countries -including 40% of all low-income countries and 30% of all middle-income countries. However, only a small portion (14%) of the relevant implementation events that we did trace involved the use of the guidelines in the formulation of policy -arguably the use with the greatest potential impact.
Since their publication, the guidelines appear to have been used most frequently to conduct needs assessments. This use is consistent with the relatively recent publication of the guidelines and the fact that, in many countries, the systematization of trauma care is only just beginning. We identified only four countries -i.e. Ghana, India, Mexico and Viet Nam -in which use of the guidelines in a needs assessment had been followed-up with documentation of how the issues identified in the assessment had been addressed. 27,37,41,48,76,77,79 Follow-up on other needs assessments is clearly an area for future research and advocacy.
Although WHO guidelines have been associated with weak stakeholder

Low-income
Burkina Faso GETC incorporated into an educational module for humanitarian aid workers. 86 Cambodia GETC used to develop questionnaires that were administered in a nationally representative sample of 85 health centres and 17 referral hospitals. 39 The same guidelines were used by ministry of health planners. 79 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35

Ethiopia
Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35

Haiti
Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35

Liberia
GETC were required reading for the resident physicians taking an online course in emergency medicine. 88 An assessment of an emergency department in Monrovia was compared with the standards defined in PTCS guidelines. 99 GETC and/or GTQIP used to conduct one-day courses for trauma care providers. 111

Madagascar
A course based on PTCS guidelines was taught to taxi drivers, as part of a plan to develop a system of lay firstresponders. 109

Malawi
Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 Mozambique WHO, national and local government and other external expert representatives conducted a case review, of the trauma system in Maputo, that was based on criteria from GETC and PTCS guidelines. The results led to recommendations for strengthening the trauma system -including injury surveillance. 27,38,75 Rwanda GETC used to develop a survey tool to assess the surgical and anaesthesia infrastructure at 21 district-level hospitals. 43

Sierra Leone
GETC incorporated into an educational module for humanitarian aid workers. 86

Uganda
GETC and PTCS guidelines incorporated into survey of providers of prehospital care in Kampala and subsequently used as the foundations of a lay first-responders' course. 53,106 A professional society report -from the Bellagio Essential Surgery Group -committed to the revision and adaption of GETC and PTCS guidelines. 62 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 United Republic of Tanzania GETC used in the formation of a survey tool used to assess ten hospitals. 36 GETC and GTQIP used, by a PhD student in an ongoing project, to investigate the suitability of local trauma system development. 47

Lower-middle-income Armenia
Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 Bolivia (Plurinational State of ) PTCS guidelines used as the basis for a lay first-responders' course. 107 Cameroon GETC used to create a tool to assess the physical and human resources and organizational capacity of district hospitals in the Central region. 26

Ghana
GETC used by ministry of health planners 27 and served as the basis for a high-profile stakeholders meeting that resulted in a set of policy recommendations that were presented to parliament. 72 The same guidelines used to assess physical resources for trauma care, 48,80 including, specifically, for paediatric trauma care. 58 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 PTCS guidelines adapted to test the knowledge of emergency medical technicians in Accra 92 and served as the basis for a survey, on the status of prehospital care, that was distributed to the leaders of emergency medical services. 94 GTQIP implemented, via the institution of preventable death panels, at an academic hospital. 115

India
GETC used for needs assessments of trauma care capabilities nationally, 22,49 targeted in Alappuzha district 45 or with a focus on either human resources 28 or the availability of technology. 55 In 2003, in Gujarat, the department of health, a WHO subcountry office and representatives of local and international professional groups held a meeting to adapt GETC to local circumstances. 77 A similar meeting regarding implementation strategies was held in 2005. 27 GETC were endorsed by the Academy of Traumatology 27 and referenced in a working paper, commissioned by the government, that made recommendations for stabilizing the trauma system. 71 GETC used to assess a training programme for trauma teams 89 and incorporated into a pilot two-day intensive trauma course for physicians in Bangalore. 84 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 PTCS guidelines served as basis for a survey, on the status of prehospital care, that was distributed to the leaders of emergency medical services. 94 The same guidelines were referenced in a National Institute of Mental Health and Neurosciences public health alert that recommended development of a first-tier trauma response. 102 The Secretary of the Neurotrauma Society cited GTQIP in a newsletter article that made an explicit call for increased quality improvement activities. 110 Indonesia GETC used to assess the hospital capacities for trauma care in East Timor. 51 Kenya GETC used as basis for needs assessment of district and provincial hospitals and health centres 19,56 and taught as part of a two-day course for medical providers. 111 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 PTCS guidelines served as basis for a survey, on the status of prehospital care, that was distributed to the leaders of emergency medical services. 94

Morocco
GETC used as the basis for an assessment of a university hospital and its associated prehospital system. 29

Myanmar
Course materials regarding morbidity and mortality conferences -which were developed from GTQIP -were incorporated into a training course for trauma teams. 112

Nicaragua
Grant proposal included a needs assessment and the development of an emergency medicine handbook that were based on GETC. 40 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 (continues. . .)

Reported implementation events
Nigeria GETC incorporated into an online university curriculum 85 and recommended for implementation -and cited as a stimulus for external rotations for medical providers -in a programme of training in advanced trauma care. 63 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 A conceptual framework for a literature review of the trauma system was based on PTCS guidelines. 93

Pakistan
GETC and PTCS guidelines used to develop a questionnaire administered to 141 staff members at ambulance stations along an interurban road. 23,98 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 42,46 GETC and GTQIP used, by a PhD student in ongoing project, to investigate the suitability of local trauma system development. 47 Brazil GETC used to assess physical and human resources for care at a regional trauma centre. 20 PTCS guidelines served as the basis for a survey, on the status of prehospital care, that was distributed to the leaders of emergency medical services. 94 A continuing education course for health-care professionals was based on GTQIP. 111 China GETC were required reading for nursing students enrolled in an online summer elective course. 87 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35

Colombia
PTCS guidelines used for a needs assessment and subsequently incorporated into national legislation that stipulated basic qualifications for providers, included equipment lists and made audits mandatory. 27,90 GETC also used as the basis for a needs assessment. 27 Ecuador GETC used in needs assessments, for the general care of trauma and for the care of traumatic brain injury, at 24 sites in seven provinces. 27,34 The same guidelines were also endorsed by the Ecuadorian Trauma Society and used by ministry of health planners. 27,79 PTCS guidelines served as the basis for a survey, on the status of prehospital care, that was distributed to the leaders of emergency medical services. 94 Iran (Islamic Republic of ) Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 Jamaica Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 Lebanon GETC used as the basis for a national survey of the resources available for paediatric trauma care. 33 A plan to train official ministry of health emergency responders to a level defined in PTCS guidelines is being implemented. 108

Malaysia
Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 The advanced life support equipment available on 1075 ambulances was compared with recommendations in PTCS guidelines. 97 A continuing education course for health-care professionals was based on GTQIP. 111

Mexico
GETC used for needs assessments at 16 facilities, 41 endorsed by the Mexican Association for the Medicine and Surgery of Trauma, 61 used by ministry of health planners 27 and referenced in national standards. 76 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 PTCS guidelines served as the basis for a survey, on the status of prehospital care, that was distributed to the leaders of emergency medical services 94 and were subsequently incorporated into national legislation that stipulated basic qualifications for providers, included equipment lists and made audits mandatory. 27 119 about one in every four implementation events that we traced involved endorsement of guidelines by at least one professional society. Ideally, with time, the main types of implementation events will shift away from data gathering and stakeholder endorsements towards more incorporation of the guidelines into educational curricula and health policy.
Over our study period, incorporation of the guidelines into educational interventions appeared to be a rare event -documented just 19 times overall and only once as a graduation requirement for resident physicians. 112 The global dearth of formal trauma education for physicians was documented in 2009, in a survey of 774 final-year medical students in 77 countries; only 55% of the surveyed students reported they were comfortable providing basic trauma care. 120 We recommend that the guidelines be incorporated into the mandatory degree requirements for medical professionals.
The WHO's trauma care guidelines were developed specifically for guidance at health ministry level. The relative lack of the guidelines' implementation at

Reported implementation events
South Africa GETC used as the standard against which the inpatient trauma care facilities in KwaZulu-Natal were compared; the results led to a proposal for the development of a local trauma system. 31 After GETC and GTQIP were used to assess the resources for trauma care in a rural health district, the Trauma Society of South Africa used the results to recommend the development of trauma registries and improvements in trauma care to the government. 52 Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 PTCS guidelines served as the basis for a survey, on the status of prehospital care, that was distributed to the leaders of emergency medical services. 94 They also formed the basis of a separate targeted questionnaire used in Limpopo province, 95 and recommendations on national guidelines for assessment of trauma centres. 103

Thailand
Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 A continuing education course for health-care professionals was based on GTQIP. 111 The former Yugoslav Republic of Macedonia The findings of a needs assessment based on the GTQIP were integrated into official strategy for emergency medical services 2009-2017. 116 High-income Argentina GETC formed the foundations of a 2010 consensus statement by the Intersociety Coalition for the Professional Certification, Categorization and Institutional Accreditation in Trauma, Emergency and Disasters. 59

Croatia
Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 France PTCS guidelines referenced in national legislation, proposed in 2009, that was designed to add basic training in first aid to the requirements for acquiring a driver's licence. 105

Germany
The definition of preventable from GTQIP was used in a study of mortality among injured children in a trauma centre. 114 Poland PTCS guidelines used, for comparison, in an assessment of the adequacy of the injury response system. 91

Portugal
GETC and GTQIP referenced seven times and twice, respectively, in national norms. 82

Saudi Arabia
Published reports of trauma registries were evaluated using a tool derived from GETC and GTQIP. 35 GETC also used to assess trauma care services in the capital, Riyadh. 50 United Kingdom GTQIP referenced in the Royal College of Anaesthetists' professional guidelines that recommended preventable death panels, governance meetings and morbidity and mortality meetings. 118 United States of America American Society of Health-System Pharmacists recommends use of GETC. 66 Region Global Geneva declaration policy paper recommends GTQIP implementation. 64 National Center for Injury Prevention and Control works with national and international public health partners to promote GTQIP implementation. 101 WHO published GETC as checklist to facilitate use as needs assessment. 44 WHO/Global Health Workforce Alliance/ UNICEF/IFRC/ UNHRC recommend use of GETC in joint statement regarding scale-up of community-based health workforce. 65

GETC recommended in WHO's Speed Management: A Road Safety Manual for Decision-Makers and
Practitioners. 73 GETC recommended in WHO's Preventing violence and reducing its impact. 74

Africa
African Federation for Emergency Medicine recommended implementation of GETC and PTCS in workgroup consensus paper. 60 Executive board report of the WHO regional director describes plans to implement GETC and PTCS at regional and country level. 70

Systematic reviews
Use of WHO's trauma care guidelines Lacey LaGrone et al.
national policy level is therefore cause for concern. In the implementation of WHO guidelines, the interaction between researchers and health-care policy-makers has previously been identified as needing improvement. 121 Our search revealed excellent examples of such interaction in Ghana, India and Mexico, where there had been nationallevel consensus meetings in which WHO trauma experts, trauma care professional societies and ministry of health representatives had collaborated to adapt the WHO trauma care guidelines to local circumstances. 27 In addition to increased researcher and policy-maker interaction, the more intentional distribution of guidelines among policymakers is a ready area for improvement. The findings of this systematic review indicate that the guidelines are most readily accessible in clinical journals or other types of information source that are probably accessed primarily by clinicians, not policy-makers.
In considering how to improve implementation of the trauma care guidelines, an article commissioned by WHO to address dissemination and implementation strategies might prove useful. This article states that WHO did not have a general, unified strategy for the dissemination and implementation of guidelines and that there was considerable room for improvement of the applicability, dissemination, implementation and timeliness of WHO guidelines. 121 With regard to applicability, several of the information sources we included in our analysis commented specifically on the appropriateness of the guidelines for low-and middle-income countries. [122][123][124][125] However, most of the implementation events we traced were reported in English-language information sources and none appeared to have been reported in Arabic -indicating a need for wider dissemination of guidelines among the countries, including most low-and middle-income countries, where English is not the predominant language. With regard to timing and timeliness, the dissemination of the guidelines we investigated coincided with an increasing awareness of the substantial contribution made by noncommunicable diseases in generaland injury in particular -to the global disease burden. 1 This study has several limitations. Most importantly, given the chosen method, we cannot make any comment regarding the outcomes of any implementation. We can only state that the guidelines have been used in a certain way and cannot comment on the impact of that use. To assess the outcome of guideline implementation, further research -e.g. examination of process-of-care measures from sentinel sites where the guidelines have been adopted -is recommended. We made no effort to alleviate or evaluate concerns that the development of systems for trauma care might cause harm by diverting resources from other health systems. However, since injury has a disproportionate impact on people of working age, improving outcomes after injury is expected to have a substantial positive impact on a country's overall resources. 1 Furthermore, the trauma system development recommended in the WHO's guidelines frequently entails a more efficient use of existing resources rather than an infusion of new ones. Finally, some improvements in trauma systems -e.g. in prehospital care, referral and patient transport networks and hospital staff training in patient triage and resuscitation -could be expected to benefit patients across a spectrum of acute-care pathologies, including obstetrics and cardiovascular and cerebrovascular diseases. Nonetheless, we acknowledge that, apart from one published report citing the beneficial effect of trauma system development on the outcomes of patients with ruptured aortic aneurysms, 126 there is currently a lack of evidence that trauma system development improves health systems overall. Thus, thoughtful development of trauma systems should include the purposeful avoidance of: (i) duplication; (ii) distortions, such as the creation of a separate elite cohort of better-resourced health workers; (iii) disruptions, such as those caused by leaving posts vacant while health workers are trained; and (iv) distractions, such as specific reporting and other uncoordinated timeconsuming tasks. 127,128 Several of the authors in this study have an interest in reporting the implementation of the WHO's guidelines. They attempted to minimize this potential source of bias by recruiting a co-author -who was not professionally involved with the topic or with the other authors or members of the advisory group -to review the implementation data independently.
An additional weakness of the study is the inclusion of only reports that were available electronically, via the Internet, or known to the 20 experts who were consulted. The use of the guidelines we investigated is likely to be considerably greater than the use we traced. Also, as we selected the experts who we would contact based on their frequent citation in the initial literature search, we failed to contact experts who have not published many articles. We decided to conduct a systematic review because we  (62) 77 (55) Other journal 5 (5) 0 (0) 2 (7) 7 (5) Professional society report 2 (2) 5 (29) 2 (7) 9 (6) Web page or blog 5 (5) 0 (0) 2 (7) 7 (5) Conference proceedings 2 (2) 1 (6) 0 (0) 3 (2) Thesis

Systematic reviews
Use of WHO's trauma care guidelines Lacey LaGrone et al.
felt that remote surveys of stakeholders -which might, in theory, give a better balanced picture -were often associated with low response rates and inaccurate, anecdotal evidence. Although on-site interviews with stakeholders might allow more detailed investigation of trauma care guidelines in the future, they will require more labour and more resources than the systematic review we conducted.
Despite these limitations, this review adds substantially to the literature. It confirms that, as intended, WHO's trauma care guidelines are being used in low-and middle-income countries across the globe, for needs assessments, education and policy development and with stakeholder endorsement. However, implementation of the guidelines has been documented in a minority of the WHO's 194 Member States. Possible areas for high-yield and appropriate improvement in the implementation of the guidelines include increasing policymakers' awareness of the guidelines, incorporation of the guidelines into the formal education of most health-care providers, and systematic needs assessments based on the guidelines -to be followed by corrective action and ongoing monitoring. Вывод Хотя реализация руководящих принципов ВОЗ в области травматологической помощи носит массовый характер, авторам не удалось обнаружить подтверждение их реализации в 143 странах. Требуется увеличить количество периодических оценок потребностей для постоянного отслеживания потенциала в области травматологической помощи в системах здравоохранения, а также масштабы внедрения руководящих принципов в процесс организованного обучения работников системы здравоохранения и политику в области здравоохранения.

Resumen
Adopción de las directrices sobre la atención de traumatismos de la Organización Mundial de la Salud: una revisión sistemática Objetivo Comprender hasta qué punto se han utilizado las directrices sobre la atención de traumatismos publicadas por la Organización Mundial de la Salud (OMS) entre 2004 y 2009 e identificar las prioridades para la futura implementación y difusión de dichas directrices. Métodos Se llevó a cabo una revisión sistemática, de 19 bases de datos, en la que se utilizaron como términos de búsqueda los títulos de tres conjuntos de directrices: Guidelines for essential trauma care, Prehospital trauma care systems y Guidelines for trauma quality improvement programmes. Se validaron los resultados a través de un análisis de citas y consultas a expertos. De forma independiente, dos autores revisaron todos los informes de la implementación de las directrices.