A semi-automatic system for the chemical separation of Sr and Nd isotope analyses is proposed to attain efficient element separation. The system consists of a peristaltic pump and open column. Using the peristaltic pump, the sample solution and eluant are automatically drawn up from a test tube and loaded onto the resin bed in the column. The flow rate of the pump is adjusted according to the column and resin conditions. We measured the Sr and Nd isotopic ratios of samples JB-2 and JA-3 prepared using the proposed technique; the results are in good agreement with previously reported values. The proposed system reduces the required analysis time, and, unlike other automated systems, is applicable for any type of open column, resin, and geological material. The system has the added benefit of not requiring expensive additional instrumentation.