神戸大学附属図書館デジタルアーカイブ
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https://doi.org/10.24546/81003703
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2024-05-31
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81003703 (fulltext)
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81003703
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open access
出版タイプ
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タイトル
Expression of Beta-catenin and Integrin-linked Kinase in the Mouse Sciatic Nerve
著者
Takeuchi, Junichiro ; Shibuya, Yasuyuki ; Murata, Maho ; Komori, Takahide
著者名
Takeuchi, Junichiro
竹内, 純一郎
タケウチ, ジュンイチロウ
著者名
Shibuya, Yasuyuki
澁谷, 恭之
シブヤ, ヤスユキ
著者名
Murata, Maho
村田, 真穂
ムラタ, マホ
著者ID
A0121
研究者ID
1000050251294
著者名
Komori, Takahide
古森, 孝英
コモリ, タカヒデ
所属機関名
医学研究科
収録物名
The Kobe journal of the medical sciences
巻(号)
54(4)
ページ
217-226
出版者
神戸大学医学部
Kobe University School of Medicine
刊行日
2008-08
公開日
2011-12-08
抄録
In the present study, the expressions of beta-catenin and integrin-linked kinase (ILK) in the adult mouse peripheral nerve were investigated by means of immunoblotting analyses and electron microscopy using the immunogold pre -embedding method. As a result, beta-catenin and ILK were shown to be expressed both in the axon and the Schwann cell of the myelinated and unmyelinated fibers. By electron microscopy, some molecules of beta-catenin and ILK tended to concentrate under the axolemma in the unmyelinated fibers, while these molecules were distributed in a scattered form throughout the axoplasm in the myelinated fibers. Concerning the cytoplasm of the Schwann cells, the loop region was too slender to detect whether beta-catenin and ILK were associated with the plasmalemma; however, beta-catenin and ILK were distributed diffusely without any relationship in regard to the plasmalemma or the cell organelles around the nucleus region. The density of beta-catenin and ILK around the nucleus region was greater than that within the nucleus region. From these results, some molecules of beta-catenin mediate the axon-Schwann cell adhesion of the unmyelinated fibers, while other molecules are thought to be separated from the cadherin-catenin complex on the plasmalemma. Accordingly, it is hypothesized that the cell-cell adhesion property in the peripheral nerve is not strong but dynamic, and this adhesion is possibly regulated by ILK.
カテゴリ
医学研究科
The Kobe journal of the medical sciences
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54巻
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54巻4号(2008-08)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
0023-2513
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NCID
AA00711740
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URI
http://www.med.kobe-u.ac.jp/journal/contents.html
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