Almost Total Airway Obstruction Due to Unidentified Massive Hemoptysis under Extracorporeal Membrane Oxygenation

C l i n M e d International Library Citation: Kazuma S, Masuda Y, Tatsumi H, Takahashi K, Yoshida S, et al. (2016) Almost Total Airway Obstruction Due to Unidentified Massive Hemoptysis under Extracorporeal Membrane Oxygenation. Int J Crit Care Emerg Med 2:012 Received: January 19, 2016: Accepted: February 24, 2016: Published: February 26, 2016 Copyright: © 2016 Kazuma S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Kazuma et al. Int J Crit Care Emerg Med 2016, 2:012


Introduction
When life-threatening hemoptysis occurs, it is difficult to determine the focus of hemorrhage and to perform selective hemostasis in many cases.In this situation, it is difficult to maintain respiratory function due to mechanical obstruction by blood clots and blood aspiration.
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has been used in clinical practice for a number of years.It has been used successfully for the management of acute reversible pulmonary failure.Thus, VV-ECMO can be used for respiration in patients with life-threatening hemoptysis in which the bleeding focus cannot be identified, even if there is nearly total airway obstruction.
We report a successfully treated case of almost total airway obstruction due to unidentified massive hemoptysis under extracorporeal membrane oxygenation

Case Presentation
A 54-year-old female weighing 62 kg had hemoptysis with an unidentified focus 4 months before and had been followed in the Department of Respiratory Medicine.Angiographic embolization was performed for a right bronchial artery ramification suspected of being the bleeding focus by bronchofiberscopy, but there were few effects.Right middle lobectomy was performed to control the persistent hemoptysis, and tracheal extubation was performed on the second day of illness.Sustained hemoptysis developed again 8 hours after extubation.Tracheal intubation and mask ventilation were difficult due to trismus, her short neck and blood in her oral cavity, and she went into cardiopulmonary arrest within a few minutes.There was repetition of return of spontaneous circulation and cardiopulmonary arrest while trying to maintain the airway.Then veno-arterial extracorporeal membrane oxygenation (VA-ECMO) was performed via femoral vessels.

ISSN: 2474-3674
In consideration of post cardiac arrest syndrome, the temperature of blood sent by VV-ECMO was controlled at normothemia (bladder temperature controlled within 35-36°C) for neuroprotection [1].Activation coagulation time (ACT) was managed by administration of heparin within 120-160 seconds, which is shorter than that in usual ECMO management for massive hemoptysis.The right inferior lobe, where retention of some blood was observed at the time of the first operation, was suspected of being a bleeding focus of the hemoptysis, and right inferior lobectomy was performed on the same day.In the surgery, blood clots occluding the trachea were removed by using a fogarty catheter, and tidal volume then recovered to about 350 ml.
Ventilation was stable under VV-ECMO support 2 hours after surgery, but outflows of new fresh blood gradually increased again from the nasal cavity, oral cavity, and tracheal tube.Tidal volume fell to about 100 ml, and SpO 2 was less than 90%.Removal of blood clots and fresh blood by a bronchofiberscope and Fogarty catheter was difficult.In consideration of ventilator-induced lung injury, 25 mg/hr of rocuronium was continuously administered, and the ventilator setting was changed from assisted ventilation to adjustment ventilation.Red cell concentrates were administered with the goal of Hb of 15 g/dl for the purpose of increasing oxygen delivery.SaO 2 was maintained at 75-80% by full support of VV-ECMO.
One hour later, ventilation was almost completely interrupted (Figure 1a).VV-ECMO was performed at a flow rate of 3.0-3.5L/min to maintain oxygen saturation (SaO 2 ) at 80% or more, and results of blood gas analysis showed pH of 7.30, PaO 2 of 44 mmHg, PaCO 2 of 60 mmHg, lactate of 24 mg/dL and SaO 2 of 81% (F I O 2 of 0.6 or less and peak inspiratory pressure of 25 cm H 2 O or less).The patient's condition was stable with blood pressure of 138/84 mmHg and heart rate of 104 beats/min, and transthoracic echocardiography revealed that cardiac output was sufficient.Serum lactate level did not increase and there was no organ failure.
During VV-ECMO, blood gas analysis often showed an unexpected high oxygenation level (PaO 2 , 110 mmHg; SaO 2 , 99%).It was thought that liquid ventilation with blood that filled the airway occurred because the circulation and ventilation states did not change.
After the third day of illness, outflow of new blood from the tracheal tube was not seen.Blood clots were removed again using a bronchofiberscope, and tidal volume then gradually increased (Figure 2).
On the seventh day of illness, results of blood gas analysis showed pH of 7.43, PaO 2 of 150 mmHg, PaCO 2 of 45 mmHg, and serum lactate of 11.0 mg/dl (F I O 2 , 0.45; PEEP, 5 cm H 2 O; minute volume, 7.9 L/min with no support by VV-ECMO), and VV-ECMO was therefore stopped (Figure 1b).
Tracheotomy was performed because disturbance of consciousness was prolonged, and she was transferred to a general ward on the 18 th day of illness.
Five months later, there is no paralysis, and her consciousness state has recovered to a level of being able to obey commands.The Glasgow Coma Scale score was 10 (E3VTM6).Infectious diseases such as tuberculosis, collagen disease, bronchiectasis and neoplastic disease were negative from blood tests and bacteriologic culture and by image examinations.After performing lobectomy twice, pathologic examination of operatively extracted specimens revealed features of idiopathic pulmonary hemorrhage that required differential diagnosis of congestive vasculopathy due to pulmonary venous hypertension.

Discussion
The airway of the patient was almost totally obstructed by sustained massive hemoptysis and could not be ventilated, and respiratory function was completely dependent on VV-ECMO.There have been reports on preventive management by VV-ECMO for emergency cases, but there have been very few reports on respiratory management by VV-ECMO in a situation in which the airway was almost totally obstructed [2,3].
Although VA-ECMO was performed for cardiopulmonary arrest, it was changed to VV-ECMO after return of spontaneous circulation.During partial VA-ECMO, perfusate blood in the thoracic aorta mixes with left ventricular blood that has traversed the lungs.This is the reason why unsaturated blood that has traversed the non- The blood sent by VV-ECMO is mixed with venous return (sending blood: right atrium blood = 3:1).As a result, if pulmonary function is almost totally obstructed as in this case, blood gas analysis would show PaO 2 of 40 mmHg and SaO 2 of 80% in theory.In fact, our patient showed SaO 2 of 75-80%.If Hb is more than 15 g/dl and cardiac function is good, hypoxemia without a factor raising oxygen consumption such as infection can be permitted [4,5].
In general, anticoagulant management for thromboprophylaxis is necessary during ECMO.Both ACT and activated partial thromboplastin time (APTT) is managed by administration of heparin (ACT, 180-220 seconds; APTT, 1.5-2.5 fold of the normal level of APTT, respectively).However, anticoagulant management cannot be performed positively if there is active bleeding.ACT was managed modestly within 120-160 seconds in this case.Instead, thrombogenesis was prevented by management of the flow rate of ECMO at more than 3.0 L/min since clot formation in the circuit might be fatal.
After stopping off VV-ECMO, disturbance of consciousness was prolonged, but there was a tendency for recovery, and it is thought that cardiopulmonary arrest had a great influence.
During VV-ECMO, an inexplicable rise in SaO 2 was seen repeatedly.It was thought that liquid ventilation might be effected.In general, liquid ventilation is performed with perfluorocarbon liquids that have low surface tension, and at atmospheric pressure, large amounts of oxygen and carbon dioxide dissolve in them [6].It has been reported that liquid ventilation with a perfluorocarbon improved lung functions including respiratory distress syndrome [7], congenital diaphragmatic hernia [8], and adult respiratory distress syndrome [9].It is thought that the nature of perfluorocarbon liquids is similar to that of erythrocytes containing hemoglobin.Oxygen might have been carried through blood that had filled the airway since the airway of the patient was almost totally obstructed by blood clots.