Dengue Infection Could Provoke Cardiac Arrest and Death

C l i n M e d International Library Citation: Vancini-Campanharo CR, Vancini RL, de Lira CAB, Andrade MS, Atallah AN, et al. (2016) Side Effects and Drug Interactions of Marijuana. Int Arch Nurs Health Care 2:030 Received: December 01, 2015: Accepted: January 28, 2016: Published: January 30, 2016 Copyright: © 2016 Vancini-Campanharo CR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Vancini-Campanharo et al. Int Arch Nurs Health Care 2016, 2:030


Introduction
Currently, dengue is one of the most important emerging viral diseases around the world [1,2].This disease is caused by the infection of dengue virus, which is transmitted by a mosquito called Aedes aegypti.Particularly, the highest incidence of dengue is seen in Southeast Asia, India, and the American tropics [3].Recent data suggest that infected individuals account for about half a million hospitalizations for hemorrhagic fever, and twenty thousand deaths occur every year in the world, with around 2.5 million people living in transmission areas at risk of disease.In areas where there is circulation more than one serotype can be severe forms of the infection, characterized by bleeding, circulatory shock and death [4].When the patient came to the emergency room was conscious, breathing, and had pulse.In the initial evaluation presented 89% of oxygen saturation and in the chest X-ray had diffuse pulmonary infiltrate.The results of laboratory tests showed: erythrocytes 5.75 M/uL; hemoglobin 16.3 g/dl; hematocrit 49.1%; leukocytes 8360/ μL; atypical lymphocytes 6.0%; platelets 86000/μL; activated partial thromboplastin time 68.5; prothrombin time 14.2; prothrombin activity 85; INR 1.11; urea 29 md/dl; creatinine 0.73 mg/dl; glutamic oxalacetic transaminase 165 U/L; glutamic pyruvate transaminase 54 U/L; gamma glutamyltransferase 47 U/L; alkaline phosphatase 92 U/L and creatine kinase 2095 U/L.He was placed in the oxygen face mask and receiving antibiotic treatment.After 12 hours of hospitalization experienced worsening of respiratory distress and then had cardiac arrest (CA).The patient received care in the emergency room and CA was witnessed.The presumed cause of the CA was acute respiratory failure and the initial rhythm was pulseless electrical activity.Immediately, cardiopulmonary resuscitation (CPR) was started, with ventilations, external chest compressions, and administration of epinephrine.After 37 minutes, the patient died and the death cause was pulmonary hemorrhage.

Discussion
In our study, the patient infect by dengue, unfortunately, present CA and died by respiratory complications associated with pulmonary hemorrhage since chest X-ray present diffuse pulmonary infiltrate, despite of emergency monitoring and health care.Particularly, this event associated with dengue infection has rarely been reported by the medical literature [10][11][12].However, dengue can cause diffuse alveolar hemorrhage which represents a syndrome that can complicate many clinical conditions.It is recognized by the signs of acute cough, hemoptysis, diffuse radiographic pulmonary infiltrates, and hypoxemic respiratory distress (our patient in the initial evaluation presented 89% of oxygen saturation) [11].
The pathophysiology of extreme dengue fever (dengue haemorrhagic) is a transient increase in pulmonary vascular permeability resulting in plasma leakage [13,14] and cardiovascular collapse [2].The most common causes of death in dengue haemorrhagic include bleeding into vital organs, massive bleeding, and hypovolaemic shock [5,15,16].The pathogenesis of hypovolaemic shock is poorly understood and traditionally, has been described to loss of intravascular fluid due to increased capillary permeability and bleeding [3,5,17].
Previously, Wali JP et al. [5] report a dengue case infection of 44-year-old patient which evolutes to dilated cardiomyopathy.In addition, this patient presented severe acute pulmonary symptoms (hypoxic respiratory failure) and despite aggressive treatment, patient died.Pulmonary involvement is related to severe forms of the disease and it is necessary to consider other diagnostic possibilities during dengue outbreaks [10].
Note that in some cases of death from suspected dengue serology for this disease can be negative, requiring a necropsy, which may show involvement of the various organs and systems by the disease [4].

Final Considerations
Dengue has become very prevalent in tropical and subtropical regions, affecting hundreds of thousands people [10].Early diagnosis and prevention of dengue fever is essential for the appropriate supportive treatment and management and can improve the patient survival [5,18].Cardiac dysfunctions, and consequently other physiological system complications (pulmonary disorders), may have a contributing role in the pathogenesis of shock and could also influence the outcome of the dengue, despite the mechanism leading to the development of shock is complex and remains largely unknown [5].If significant cardiac involvement and failure is present, preventive management strategies and advanced life support should be applied to prevent mortality and morbidity by dengue.However, lung abnormalities are not common in dengue infection and probably reflect increased vascular permeability due to cardiac dysfunction.
Despite of this, it is important that health professional know about this complication of dengue.

Consent
This study was approved by the Ethics and Research Committee of Universidade Federal de São Paulo (protocol -0030/2011).All procedures were performed according to the Declaration of Helsinki.Due to the observational nature of the data collection and the severity of the patients' condition, the study was granted release from consent term.