Acute Compartment Syndrome Following Anterior Cruciate Ligament Reconstruction with Autologous Hamstring Graft

C l i n M e d International Library Citation: Wheatley B, Oetgen M (2016) Acute Compartment Syndrome Following Anterior Cruciate Ligament Reconstruction with Autologous Hamstring Graft. Trauma Cases Rev 2:035 Received: February 03, 2016: Accepted: March 30, 2016: Published: April 01, 2016 Copyright: © 2016 Wheatley B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Acute Compartment Syndrome Following Anterior Cruciate Ligament Reconstruction with Autologous Hamstring Graft


Introduction
Compartment syndrome is an extremely rare complication described in association with anterior cruciate ligament (ACL) reconstruction [1].Previous reports have described this complication as a result of extravasation of fluid into dependent compartments [2][3][4][5][6][7].There has also been report of compartment syndrome following ACL reconstruction due to anterior tibial artery injury during tibial tunnel placement [8].One proposed mechanism is from a capsular defect that allows irrigation fluid to flow from the joint into lower leg muscular compartments.However, no reports could be found linking the development of compartment syndrome to bleeding from the graft harvest site.To our knowledge, this is the first report of compartment syndrome following ACL reconstruction with utilization of hamstring autograft.

Case Report
The patient is a 16 year old male, who suffered a right (ACL) injury while playing football in September, 2013.He was seen and evaluated at an outside facility and an MRI of the right knee showed disruption of the posterior bundle of the ACL with partial disruption of the anterior bundle.He is an otherwise healthy, athletic individual with no significant past medical history.His family history is noncontributory and of note there is no history of bleeding diathesis.
On December 23 rd , a femoral nerve block was placed with ropivicaine and he was then taken to the operating room.Diagnostic

ISSN: 2469-5777
Wheatley and Oetgen.Trauma Cases Rev 2016, 2:035 within a confined space secondary to any cause.The resultant increase in pressure can reduce the perfusion pressure gradient thereby reducing oxygen delivery to local tissues.The pressure can also compress veins decreasing venous drainage further reducing perfusion pressure and leading to direct compression on nerves [9][10][11].Reduced oxygen delivery can cause ischemic necrosis of muscle and nerve tissue resulting in irreversible injury within 6-10 hours of onset.Compartment syndrome is most commonly related to fractures with tibial diaphyseal, distal radius and forearm being the most common underlying cause [11].Compartment pressures 20-30 mmHg below the diastolic pressure have been shown to be the critical tissue pressure threshold.Compartment syndrome is primarily a clinical diagnosis with the cardinal signs of pain with passive motion and paresthesias.Intra-compartmental pressure monitors have allowed for objective findings to aid in the diagnosis.
Arthroscopy is an extremely common tool within orthopedics with a wide variety of surgeries being performed with minimally invasive techniques.The majority of complications in arthroscopic ACL reconstruction stem from technical errors including tunnel placement, graft fixation and damage to surrounding structures [12,13].Previous studies have reported an approximately 5-10% complication rate with less than 1% having therapeutic consequences [14,15].The formation of DVT has been reported as a common complication in up to 10% of patients when routine screening is performed, however, the majority of these are distal and clinically insignificant [16].The use of an infusion pump during arthroscopy has also been cited as a source of complications in which fluid has extravasated out of the knee during surgery and has rarely been associated with the development of compartment syndrome [17].Studies have been performed with intra-compartmental pressure monitoring during and after arthroscopic knee surgery with mixed results where some report demonstrate increases in pressure postoperatively while others report no significant difference [18,19].While complications do exist in association with arthroscopic ACL reconstruction, acute compartment syndrome has only rarely been described and is most commonly attributed to the extravasation of irrigation fluid.
Previous reports of compartment syndrome have been described in association with peripheral nerve blocks [20,21].Therapeutic and prophylactic anticoagulation has been associated with increased risk of bleeding and compartment syndrome following the placement of a nerve block [20].Peripheral nerve blocks have been more commonly described in delaying the diagnosis of compartment syndrome that developed as a result of other causes [22].medial incision was then made and the superficial and deep posterior compartments were released.The muscle had a dusky appearance but was contractile and no debridement was performed.A significant amount of hematoma was noted tracking from the hamstring graft harvest site to the superficial compartment.The skin was left open and wound vacs were applied to the medial and lateral incisions.The patient was then transferred to the inpatient ward.
Later that night, the patient reported the pain in his right leg had improved.Over the course of the next day, his pain continued to improve and repeat ultrasound of the right lower extremity was performed which showed no evidence of occlusive clot and normal compression of all vessels with satisfactory waveforms.He was taken back to the operating room on December 28 th for irrigation and debridement, wound vac exchange and partial closure.On December 30 th , he underwent delayed primary closure of the medial and lateral incisions.He was discharged on January 2 nd in good condition and his pain was well controlled.
On January 5 th , the patient was readmitted to our service due to acute pain exacerbation.An ultrasound of the lower extremity was performed which showed a large heterogeneous collection in the medial calf consistent with a complex hematoma and no evidence of deep venous thrombosis.The pain service was consulted for management of neuropathic pain and the patient was started on gabapentin.On January 6 th , there was persistent draining of dark blood from the hamstring graft harvest site.The Hematology service was consulted to rule out possible bleeding diathesis.A von Willebrand's panel, factor VIII level, platelet function assay and thromboelastography study were obtained.The factor VIII level was 206%, vWF 45%, collagen/epinephrine was within normal limits at 190 sec and ADP was elevated at 141 sec.Coagulation review showed there is no coagulation factor deficiency, abnormal clot formation or abnormal lysis by thromboelastography.On January 9 th , the patient returned to the operating room for irrigation and debridement of the hamstring graft harvest site due to continued drainage from the surgical site.Cultures obtained showed no evidence of infection and the drainage subsequently subsided.
The patient was subsequently discharged.At final follow-up, the patient was doing well.The surgical sites had healed without complication.His sensation had returned to normal and he suffered no motor deficits.

Discussion
Compartment syndrome is described as the increase in pressure Another potential cause of acute compartment syndrome in arthroscopic ACL reconstruction lies in the use of a tourniquet.Serious complications as a result of the use of a tourniquet are rare and are seldom found when used correctly and for a short duration [22][23][24].Complications have been described with prolonged use and care must be taken to ensure the tourniquet is not left inflated for extended periods of time with allowing for rest [13].
Compartment syndrome following ACL reconstruction has previously been reported due to anterior tibial artery injury due to tibial tunnel placement [8].The intraoperative finding of clot originating at the graft harvest site and extending into the superficial posterior compartment led us to believe that this case of compartment syndrome may have resulted from bleeding at the harvest site.According to the operative report, the tourniquet was released immediately prior to the conclusion of the case.It is possible that adequate hemostasis was not obtained prior to closure and bleeding into the posterior compartment resulted in compression of the local vasculature.Hemostasis is an essential component of any surgery and can be complicated in hamstring harvest for ACL reconstruction due to poor direct visualization of the harvest site.This could have potentially been avoided by ensuring there was adequate control of bleeding after the tourniquet was released, prior to the conclusion of the case.

Figure 1 :
Figure 1: Demonstrates blistering of the skin in the proximal medial and posterior aspects of the leg prior to surgery.