New Onset Nephropathy in a Patient with Psoriatic Skin and Joint Disease

C l i n M e d International Library Citation: Psarelis S, Corsava S, Polycarpou K, Ioannou K, Zouvani L, et al. (2015) New Onset Nephropathy in a Patient with Psoriatic Skin and Joint Disease. Clin Med Rev Case Rep 2:053. doi.org/10.23937/2378-3656/1410053 Received: June 08, 2015: Accepted: September 02, 2015: Published: September 05, 2015 Copyright: © 2015 Psarelis S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Clinical Medical Reviews and Case Reports ISSN: 2378-3656 Volume 2 | Issue 9 DOI: 10.23937/2378-3656/1410053


Introduction
A38-year-old male patientwith a background history of psoriasis since the age of 21 (1997) was referred to rheumatology due to a widespread flare of joint disease.He had been on cyclosporine 400 mg daily between 2004 and 2012 for his skin, but this was discontinued by the dermatologists due to abnormally elevated urea and creatinine.After stopping cyclosporine, the patient developed joint symptoms and his skin flared shortly (Figures 1,2).

Case Presentation
The patient was referred to rheumatology with a two-month history of a widespread joint flare affecting his shoulders, right elbow and several of his MCP and MTP joints along with evidence of dactylitis.He was commenced on methotrexate 15 mg/week but this had to be soon discontinued due to gastrointestinal side effects.His urinalysis showed a trace of protein.His inflammatory markers were raised with a CRP of 47 (<5) and ESR of 54 (<0-14).Creatinine was raised at 2,6 mg/dl [0,51-0,95], urea 90 mg/dl [17-43], C3 and C4 were 125 [90-130] and 35 [10-40] respectively.Serologically he had erythematosus with psoriasis/psoriatic arthritis [3].The full house immune staining demonstrated on the kidney biopsy would support such a diagnosis, although there were no clinical manifestations of lupus.Other possibilities include post-infective nephropathies like HIV and HCV-related nephropathies which were screened for and shown negative in this case.
Taking into account all the above, the working diagnosis in this case was that of "Psoriatic Nephropathy", a fairly well-described entity [4,5].Mesangio proliferative glomerulonephritis with IgA, C3 and C1q deposition on the mesangium and basal membranes of glomerular capillaries appears to be the commonest type in psoriasis, although focal proliferative glomerulonephritis and Focal Segmental Glomerulosclerosis (FSC) as well as minimal change disease have also been reported albeit less commonly [4][5][6].
Recent evidence suggests that an increasing number of patients with skin psoriasis develop renal dysfunction [6][7][8][9].In one case, renal transplant completely alleviated all psoriatic manifestations with the patient remaining psoriasis free ever since [9].This raises important issues regarding the correlation between psoriasis and kidney disease and merits further investigation.Considering thorough investigations and kidney-biopsy in such patients to identify the exact mechanism of FSC or minimal change disease is thus justifiable and recommended.These findings could be used to develop novel therapeutic regiments for psoriatic patients, optimizing their management.

Discussion
This is a case of long-standing psoriasis/psoriatic arthritis in a 38-year-old male on cyclosporine presenting with a new onset nephropathy at the time of skin and joint flare.The latter could be a consequence of a number of pathologies including secondary amyloidosis, iatrogenic aetiology (e.g.cyclosporine/NSAID related) or IgA nephropathy [1].Cyclosporine works by inhibiting calcineurin which through a series of complex mechanisms inhibits T-cell activation causing immunosuppresion.Cyclosporin Induced Nephrotoxicity (CIN) is thought to be caused by arteriolopathy: a consequence of altered vascular flow and constriction of the afferent arteriole diameter.An increase in thromboxane and endothelin (vasoconstrictive factors), activates the Renin-Angiotensinaldosterone System (RAAS) resulting in increased aldosterone and angiotensin II levels, reduced Nitric Oxide and prostacyclin (vasodilator factors) promoting eventually prothrombotic activity in the glomeruli.Decreased levels of COX-2 cyclo oxygenase have also been reported in CIN, as have increased levels of TGFβ1 factor all contributing to treatment-resistant hypertension.However our patient, although on long term cyclosporine did not have any signs or symptoms consistent with CIN.Moreover the kidney biopsy showed C3 and C1q deposits which have not been specifically reported in CNI [2].
Less likely causes would be the co-existence of lupus  This case highlights that nephropathy in the context of Psoriatic skin and joint disease can and does occur and high vigilance is necessary.An autoimmune, inflammatory mechanism could link the two although usage of nephrotoxic drugs in psoriasis should be kept in mind and carefully considered.The complexity of these cases necessitates close monitoring and follow-up with involvement of appropriate specialists early on.