Urinary Incontinence as a Presenting Symptom of Bladder Cancer

C l i n M e d International Library Citation: González EV, de la Fuente MP, Díaz EG (2016) Urinary Incontinence as a Presenting Symptom of Bladder Cancer. Obstet Gynecol Cases Rev 3:080 Received: July 13, 2015: Accepted: March 22, 2016: Published: March 25, 2016 Copyright: © 2016 González EV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. González et al. Obstet Gynecol cases Rev 2016, 3:080 Volume 3 | Issue 3

During the next consultation, the patient had withdrawn treatment due to the lack of improvement in symptoms, and she described one episode of hematuria.Transvaginal ultrasound was performed, as we always do in our pelvic floor unit patients in their second visit [2], showing a thickened endometrium (Figure 1) and irregularities in the cavity contour.The ovaries had both proper size and aspect for her age and no free fluid was identified in the pouch of Douglas.The bladder was full during the examination, which allowed the identification of a polypoid, irregular lesion (Figure 2) of 6 mm located in the top right angle.It appeared on color Doppler imaging as highly vascular (Figure 3).Subsequent to these findings, the urology service run a cystoscopy, describing a papillary tumor of 1 cm on the right wall of the bladder.A transurethral resection (TUR) was carried out to remove the lesion, being the histopathological diagnosis of low grade transitional cell carcinoma (pTa G1).
In addition to that, the gynecology service run a histeroscopy and a endometrium curettage getting an histopathological report of well differentiated endometrial adenocarcinoma, succeeding in the performance of complete histerectomy and double anexectomy.
In the patient successive checks carried out by urologists, she presented signs of recurrence of the transitional cell carcinoma, leading to a new TUR and Bacillus Calmette-Guerin instillation.Due to the intolerance to the intravesical treatment, the patient needed a laparoscopic radical cystectomy with external urinary derivation by bilateral percutaneous nephrostomy.

Introduction
Urinary incontinence is very common in women and it often remains undetected and undertreated.Women use to think it is a normal related to age problem, so many times they don't tell about it to their doctors.Its prevalence increases with age, although estimates vary widely, becoming an important and very prevalent problem among postmenopausal women.
The initial evaluation of urinary incontinence includes the description and classification of the type of incontinence, which can be done by a direct questioning about symptoms, identifying potentially reversible causes of incontinence and identifying the underlying conditions, such as neurologic disorders or malignancy.Bladder carcinoma is a rare but possible findings in patients who have urinary incontinence.Initial diagnosis does not require any invasive test [1].We have to consider additional testing in those high risk patients [2], especially when there is no response to empirical treatments.In our gynaecologic check-up, after the initial pelvic examination and during the transvaginal ultrasound, one may insist on ultrasound scanning of the bladder.This bladder examination becomes especially important in those patients with potentially serious conditions, such as bladder cancer, or when no gynaecological pathology is found.Our ultrasound scanning should start before emptying the bladder or be repeated after its proper filling.

Case Report
The patient was a 69 year old white female, smoker, gravida 3 para 3, postmenopausal for 19 years, referred to our pelvic floor department due to urinary incontinence and nicturia.She had leakage of urine.It is a very common problem among women, affecting approximately 36% of women over 60 years [3], altering significantly their quality of life.An increase in urinary incontinence prevalence with age is caused by multiple factors including an incremented incidence of comorbidities such as obesity and diabetes, polypharmacy, and an agerelated cognitive and functional decline [4].
Urinary incontinence can be caused by many different disorders.
First of all, due to its high prevalence, we should consider several external factors as possible causes [2].The first one is urinary tract infection.Alcohol and pharmaceuticals can contribute to this condition.
The physiological changes of the genitourinary tract related to age [4] may be the origin of incontinence, as well as genital atrophy, pelvic organ prolapses or involuntary detrusor contractions.

ISSN: 2377-9004
Urinary incontinence can respond to systemic disorders, being a common complaint in obese patients [5].Nycturia is a typical manifestation of congestive cardiac failure, neurologic diseases as multiple sclerosis or some other neuropathies as the diabetic neuropathy.Other severe pathologies like malignancies can induce the incontinence [1].They should be suspected specially when no other explanation is found.UI is the most common initial symptom in urethral cancer [6], and can be the presenting symptom in bladder cancer too, as shown in our case report.
Bladder cancer is the most common malignancy of the urinary tract [7], and urothelial (transitional cell) carcinoma is the predominant histologic type.The classic presentation of bladder cancer in most patients is hematuria, grossy visible or microhematuria.It is present at initial diagnosis in the 85% of patients [8].The remaining small subgroup of newly diagnosed bladder cancer patients will present the complex of symptoms of bladder irritability and urinary frequency, urgency, and dysuria [8].Hematuria associated with irritative symptoms such as frequency, dysuria, and urgency, should be carefully examined after infection and neurogenic bladder have been dismissed because it may point to relatively advanced tumors or carcinoma in situ that extends to the bladder neck or the urethra.These voiding symptoms in bladder cancer are more common in patients with carcinoma in situ [9], and they are usually the result of a functional decrease of the storage capacity, detrusor overactivity, invasion of the trigone or obstruction of the bladder neck or urethra.
The diagnosis is often delayed because of the similarity of these symptoms to those presented in benign processes as common as urinary tract infections or interstitial cystitis [1]; delays can lead to a worse prognosis due to advanced stage at diagnosis.Men are about 3 to 4 times more likely to get bladder cancer during their lifetime [10] than women, drawing the attention of this proportion in Spain, where it raises up to 7 [11].The excess of bladder cancer in men compared to women is not completely clarified by discrepancies in smoking addiction and occupation [12] (the 2 most well-known risk factors for bladder cancer).Surveys about the incidence and mortality propose that multiparous women have a lower risk of getting bladder cancer than nulliparous women, probably due to the hormonal changes related to gestation, and that the risk may be reduced with increasing pregnancies [13].It has been proved that female patients with bladder cancer have a worse prognosis than male patients [14].
There is evidence that suggests that poorer survival in women can be related to a later diagnosis, as women are more used to suffer urinary incontinence due to physiological changes related to age [2].Women postpone consulting and clinicians often exclude benign pathologies before thinking about malignancies [14].We have to consider the possibility of bladder cancer in those high risk patients, especially when there is no response to empirical treatments, as said before; as it was our patient case, voiding symptoms due to bladder cancer characteristically does not improve with anticholinergic treatment.
The initial diagnosis of an urinary incontinence does not require any invasive test.In our gynaecologic examination, the initial physical exam of the pelvis will be followed by a transvaginal ultrasound [2,15], that offers the opportunity of examining the whole pelvis.The ultrasound would be follow by an urodynamic study and a cystoscopy [2].In high risk patients, or when no gynaecologic pathology is found, one may insist on ultrasound scanning of the bladder.In our case, the episode of hematuria that the patient referred in the second check was seen as a reason enough to suspect bladder pathology, but even without this episode, thickened endometrium does not explain voiding symptoms.
While the main goal of a gynaecological ultrasound is excluding gynaecologic pathology, examination of the bladder should become part of the standard examination procedure [15], especially in postmenopausal women, and women with unexplained symptoms as our patient.For the correct bladder examination, one may initiate the scanning prior to emptying the bladder, or repeat the examination after proper filling.The bladder should be filled with, at least, about 50 mL of urine, that will act as a negative contrast agent [16].We may be able with proper contrast to examine the bladder wall, and visualize any irregularity or solid suspicious lesion.Among them, big size and vascularization (Doppler positive) are the worst prognosis signs.Suspicious bladder lesions, as in our case, are an absolute for urgent cystoscopy indication.

ISSN: 2377-9004
While cystoscopy is the gold standard for bladder cancer diagnosis, ultrasonography has been shown to have 63% specificity and 99% sensitivity for the detection of bladder tumours [17].Underfilling and trabeculation due to bladder wall thickening are the main causes of false positive results.

Figure 2 :
Figure 2: Two dimensional imaging of the full bladder showing the irregular lesion.

Figure 3 :
Figure 3: Two dimensional power Doppler of the bladder showing the highly vascularised lesion.