REVIEW   

Minerva Biotechnology and Biomolecular Research 2023 June;35(2):127-44

DOI: 10.23736/S2724-542X.23.02977-2

Copyright © 2023 EDIZIONI MINERVA MEDICA

language: English

Bioactive compounds from Prosopis species as potential oxidative stress and inflammation modulators: an update on mechanisms

Javad SHARIFI-RAD ¹ ✉, Naoual EL MENYIY ², Alibek YDYRYS ^{3, 4}, Naoufal EL HACHLAFI ⁵, Nasreddine EL OMARI ⁶, Afaf A. ALDAHISH ⁷, Farukh SHAROPOV ⁸, Abdelhakim BOUYAHYA ⁹, Jelena ŽIVKOVIĆ ¹⁰, Charles O. ADETUNJI ¹¹, Olugbemi T. OLANIYAN ¹², Miquel MARTORELL ^{13, 14}, Eda SÖNMEZ GÜRER ¹⁵, Christophe HANO ¹⁶, Daniela CALINA ¹⁷

¹ Faculty of Medicine, University of Azuay, Cuenca, Ecuador; ² Laboratory of Pharmacology, National Agency of Medicinal and Aromatic Plants, Taounate, Morocco; ³ Biomedical Research Center, Al-Farabi Kazakh National University, Almaty, Kazakhstan; ⁴ The Elliott School of International Affairs, George Washington University, Washington DC, USA; ⁵ Microbial Biotechnology and Bioactive Molecules Laboratory, Faculty of Sciences and Technologies, Sidi Mohmed Ben Abdellah University, Fez, Morocco; ⁶ Laboratory of Histology, Embryology, and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco; ⁷ Department of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Asir, Saudi Arabia; ⁸ Chinese-Tajik Innovation Center for Natural Products Research Institution, National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan; ⁹ Laboratory of Human Pathologies, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Mohammed V University, Rabat, Morocco; ¹⁰ Institute for Medicinal Plants Research “Dr Josif Pančić”, Belgrade, Serbia; ¹¹ Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Auchi, Nigeria; ¹² Laboratory for Reproductive Biology and Developmental Programming, Department of Physiology, Edo University Iyamho, Auchi, Nigeria; ¹³ Department of Nutrition and Dietetics, Faculty of Pharmacy and Center for Healthy Living, University of Concepción, Concepción, Chile; ¹⁴ Unit of Technological Development, University of Concepción, Concepción, Chile; ¹⁵ Department of Pharmacognosy, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Türkiye; ¹⁶ Laboratory of Tree and Field Crop Biology (LBLGC), University of Orléans, Orléans, France; ¹⁷ Department of Clinical Pharmacy, University of Medicine and Pharmacy, Craiova, Romania

Oxidative stress and inflammation processes are involved in most diseases and illnesses. Many herbal remedies have been shown to have anti-inflammatory and antioxidant effects, and have been used since ancient times as traditional medicine. Species of the genus Prosopis are one of these herbal remedies that grow in arid, semiarid, subtropical, and tropical areas of the world. Paste, gum, and smoke from pods and leaves of Prosopis plants are traditionally used to treat diseases related to oxidative stress and inflammation. This review aims to provide up-to-date information on Prosopis plants as oxidative stress and inflammation modulators. Relevant information was collected from researching scientific databases such as PubMed/Medline, Wiley, Web of Science and Springer. Folk medicinal applications and biologically active molecules of Prosopis spp., and its derivatives, have been collected paying attention to studies that used verified markers of oxidative stress, antioxidant capacity and inflammation. Future studies are needed to deepen more pharmacodynamic, pharmacokinetic and structure-activity relationships of phytochemicals isolated from Prosopis species.

KEY WORDS: Prosopis; Oxidative stress; Inflammation; Antioxidants