REVIEW   

Minerva Cardioangiologica 2019 June;67(3):246-53

DOI: 10.23736/S0026-4725.18.04668-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

The association of the S447X mutation in LPL with Coronary artery disease: a meta-analysis

Weiping SUN ¹ ✉, Yongquan WU ², Yumei WEN ¹, Ming GUO ¹, Haibin ZHANG ¹

¹ Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China; ² Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

INTRODUCTION: To investigate the relationships between lipase gene polymorphisms and coronary artery disease (CAD) risk.
EVIDENCE ACQUISITION: We searched PubMed, Embase and ISI web of science databases for articles estimated the association of S447X polymorphism with CAD.
EVIDENCE SYNTESIS: Twelve-five articles were included in the meta-analysis. We found the G allele S447X polymorphism could reduce CAD risk by approximately 22% (OR=0.78, 95% CI: 0.71-0.84; fixed effects, I2=35.3%, P=0.07). Compared with non-carriers, individuals with two copies of the G allele had approximately 52% risks of CAD (OR=0.48, 95% CI: 0.29-0.68), and the individuals with GG and GC+GG had approximately 19% and 26% risks of CAD compared with those with CC genotype, respectively (GC versus CC: OR=0.81, 95% CI: 0.74-0.88; [GC+GG] versus CC: OR=0.74, 95% CI: 0.68-0.80). The G allelic significantly decreased risk of myocardial infarction (MI) (OR=0.74, 95% CI: 0.57-0.92). We found significant relationship between the variant and AMD in all the genetic models (GG versus CC: OR=0.48, 95% CI: 0.18-0.79; GC versus CC: OR=0.76, 95% CI: 0.57-0.94; [GG+GC] versus CC: OR=0.73, 95% CI: 0.64-0.83).
CONCLUSIONS: The results indicated G allelic could significantly decrease CAD and MI risk.

KEY WORDS: Coronary artery disease - Mutation - Meta-analysis