ORIGINAL ARTICLE   

Minerva Surgery 2022 December;77(6):550-7

DOI: 10.23736/S2724-5691.22.09414-X

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

Role of biliary drainage before pancreatoduodenectomy for pancreatic adenocarcinoma: a retrospective study

Philipp R. SCHERBER, Gereon GÄBELEIN, Antonios E. SPILIOTIS ✉, Dorian IGNA, Sebastian HOLLÄNDER, Peter JACOB, Julia HOFMANN, Matthias GLANEMANN

Department of General Surgery, Visceral, Vascular and Pediatric Surgery, Saarland University Medical Center, Homburg, Germany

BACKGROUND: Utilization of preoperative biliary drainage prior to pancreatoduodenectomy for patients with pancreatic ductal adenocarcinoma and obstructive jaundice remains controversial.
METHODS: All patients that underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma at the authors’ institution were analyzed retrospectively to evaluate the effect of endoscopic biliary drainage on postoperative outcomes and long-term survival. Age, gender, ASA-Score, operative time, blood loss, intraoperative transfusion rate, and postoperative complications, including postoperative pancreatic fistula, delayed gastric emptying, bleeding, bile fistula, wound infections, sepsis, pulmonary and cardiac complications as well as the need for relaparotomy were analyzed.
RESULTS: Two hundred eighty-five patients with similar baseline characteristics underwent pancreatoduodenectomy, 151 patients with biliary drainage (group 1) and 134 without drainage (group 2). More than 60% of patients had one or more postoperative complications, without significant difference between the two groups (P=0.140). The overall incidence of pancreatic fistula was 21.75% in both groups (group 1: 19.87% vs. group 2: 23.88%, P=0.659). Wound healing impairment was the only postoperative complication that differed significantly between the two groups (group 1: 24.50% vs. group 2: 8.96%, P<0.001). In multivariate risk analysis, biliary drainage was the only independent risk factor for wound healing impairment (OR 4.126; 95% CI: 1.295-13.143; P=0.017). The median overall survival was similar in both groups.
CONCLUSIONS: Preoperative endoscopic biliary drainage is associated with an increased risk for wound healing impairment and wound infections. Therefore, biliary drainage should not be used routinely in patients with obstructive jaundice prior to pancreatoduodenectomy.

KEY WORDS: Pancreatic neoplasms; Jaundice, obstructive; Cholangiopancreatography, endoscopic retrograde; Pancreatectomy