ORIGINAL ARTICLE   Free access

Esperienze Dermatologiche 2018 June;20(2):27-31

DOI: 10.23736/S1128-9155.18.00474-0

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Evaluation of the soothing effect of Eupilen® topical formulation on radiotherapy-induced dermatitis

Giada MARAMALDI ¹, Ambra CORTI ², Martino MENEGHIN ¹, Maria Rosaria CESARONE ³, Roberto EGGENHOFFNER ⁴, Luca GIACOMELLI ^{2, 4} ✉, Gianni BELCARO ³, Stefano TOGNI ¹

¹ Indena S.p.A, Milan, Italy; ² Polistudium SRL, Milan, Italy; ³ Department of Medical and Oral Sciences and Biotechnology, Irvine3 Labs, University of Chieti-Pescara, Chieti, Italy; ⁴ Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy

BACKGROUND: Eupilen® is a topical formulation containing a blend of natural active ingredients specifically combined to counteract sensitive skin discomfort. In this pilot study, we assessed the efficacy and safety of Eupilen® topical formulation as soothing and lenitive agent in patients undergoing radiotherapy for cancer treatment.
METHODS: We enrolled patients treated with radiation therapy for different types of cancer. All study participants freely decided to follow either a standard management (SM) protocol, consisting in the application of dexpanthenol, or SM associated with Eupilen® topical formulation (N.=19 for each group).
RESULTS: Patients treated with Eupilen® reported a consistent beneficial effect in the reduction of several radiation-induced skin damages. After 4 weeks, patients treated with Eupilen® + SM reported a marked decrease in occurrence of skin redness, skin peeling, edema and local pain associated with radiation therapy, with superior results compared to patients treated with SM alone.
CONCLUSIONS: This pilot investigation suggests that Eupilen® topical formulation may help reduce skin redness, skin peeling and others symptoms of radiation-induced skin toxicity in patients treated for cancer.

KEY WORDS: Radiodermatitis - Administration, topical - Skin diseases