NIPPON SUISAN GAKKAISHI
Online ISSN : 1349-998X
Print ISSN : 0021-5392
ISSN-L : 0021-5392
Identification of Okadaic Acid As a Toxic Component of a Marine Dinoflagellate Prorocentrum lima
Yasutaka MURAKAMIYasukatsu OSHIMATakeshi YASUMOTO
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JOURNAL FREE ACCESS

1982 Volume 48 Issue 1 Pages 69-72

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Abstract

Two diethyl ether soluble toxins (PL toxin-I, II) and one 1-butanol soluble toxin (PL toxin-III) were isolated from a benthic marine dinoflagellate Prorocentrum lima. The major toxic component, PL toxin-II, was purified by several steps of column chromatography to yield colorless crystals: mp. 156-158°C, [α]20D+23° Physical and chemical data pointed to a molecular formula C44H68O13 having four hydroxyls, one carboxyl, seven ether linkages, three olefins, and five methyls in the molecule. A further examination of its properties and a comparison with an authentic specimen established that PL toxin-II is identical with okadaic acid, recently isolated as a cytotoxic component of two sponges Halichondria okadai and H. melanodocia.

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© The Japanese Society of Fisheries Science
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