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Synchronous liver metastases of intracystic papillary carcinoma with invasion of the breast

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Abstract

A rare case of intracystic papillary carcinoma (IPC) with invasion had synchronous metastases to the liver at presentation. A 57-year-old postmenopausal woman noticed a right breast tumor 7 months prior to admission. Mammography showed an oval mass measuring 3.1 cm in diameter with no calcification, and ultrasonography showed an intracystic tumor with a papillary growth pattern. Fine-needle aspiration cytology revealed adenocarcinoma. Excisional biopsy revealed intracystic solid papillary carcinoma with invasion. The tumor was a clear-cell type with extracellular mucin. Two months after the initial biopsy, a screening ultrasonographic examination of the liver showed multiple hyperechoic masses. Abdominal contrast-enhanced CT scan and magnetic resonance imaging (MRI) showed multiple hypervascular masses compatible with metastatic tumors. No suspicious lesions were detected on examinations for malignancy in other organs.

Distant metastases in cases of IPC with invasion are very rare. The potential of distant metastasis in IPC with invasion and the difficulty of evaluating invasive foci should be recognized. Careful evaluation of distant metastases is recommended.

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Abbreviations

IPC:

Intracystic papillary carcinoma

MRI:

Magnetic resonance imaging

ER:

Estrogen receptor

PgR:

Progesterone receptor

HER2:

Human epidermal growth factor receptor type 2

DCIS:

Ductal carcinoma in situ

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Authors and Affiliations

  1. Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-ku, 734-8551, Hiroshima, Japan

    Riki Okita, Shozo Ohsumi, Shigemitsu Takashima & Kenjiro Aogi

  2. Departments of Clinical laboratory, National Hospital Organization Shikoku Cancer Center, Japan

    Rieko Nishimura

  3. Departments of Clinical Research, National Hospital Organization Shikoku Cancer Center, Japan

    Riki Okita, Shozo Ohsumi, Shigemitsu Takashima, Kenjiro Aogi & Rieko Nishimura

  4. Department of Breast Oncology, Saitama Medical School Hospital, Japan

    Toshiaki Saeki

Authors
  1. Riki Okita
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  2. Shozo Ohsumi
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  3. Shigemitsu Takashima
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  4. Toshiaki Saeki
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  5. Kenjiro Aogi
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  6. Rieko Nishimura
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Corresponding author

Correspondence to Riki Okita.

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Okita, R., Ohsumi, S., Takashima, S. et al. Synchronous liver metastases of intracystic papillary carcinoma with invasion of the breast. Breast Cancer 12, 327–330 (2005). https://doi.org/10.2325/jbcs.12.327

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  • DOI: https://doi.org/10.2325/jbcs.12.327

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