The thermal properties, glass forming ability (GFA) and mechanical properties of a series of Ti₄₀Zr₁₀Cu_40−xPd₁₀Si_x (x=0, 1, 2) bulk glassy alloys were examined by differential scanning calorimetry (DSC), differential thermal analysis (DTA), X-ray diffractometry (XRD) and compression test. The bulk glassy alloys are expected to be used as biomedical materials because of the absence of toxic elements such as Ni, Al and Be. The glass-forming ability and thermal stability of the Ti–Zr–Cu–Pd alloy can be improved by a small amount of Si addition. The critical diameters for glass formation are 5 mm for both Ti₄₀Zr₁₀Cu₃₉Pd₁₀Si₁ and Ti₄₀Zr₁₀Cu₃₈Pd₁₀Si₂ alloys. A large supercooled liquid region of 65 K was obtained for the Ti₄₀Zr₁₀Cu₃₈Pd₁₀Si₂ bulk glassy alloy. The bulk glassy alloys have higher compressive strength of over 1900 MPa and lower Young’s modulus below 85 GPa as compared with conventional biomedical Ti alloys.