Zbornik Matice srpske za prirodne nauke 2012 Issue 123, Pages: 65-73
https://doi.org/10.2298/ZMSPN1223065H
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Myrtus comunis and Eucalyptus camaldulensis cytotoxicity on breast cancer cells
Hrubik Jelena D. (Prirodno-matematički fakultet, Departman za biologiju i ekologiju, Novi Sad)
Kaišarević Sonja N. 
(Prirodno-matematički fakultet, Departman za biologiju i ekologiju, Novi Sad)
Glišić Branka D. (Prirodno-matematički fakultet, Departman za biologiju i ekologiju, Novi Sad)
Jovin Emilija Đ. (Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine, Novi Sad)
Mimica-Dukić Neda M. (Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine, Novi Sad)
Kovačević Radmila Z. (Prirodno-matematički fakultet, Departman za biologiju i ekologiju, Novi Sad)
In vitro cytotoxicity of methanol, ethyl acetate, n-buthanol, and water
extracts of Myrtus communis L. and Eucalyptus camaldulensis Dehnh. was
examined against two human breast cancer cell lines (MCF 7 and MDA-MB-231)
using MTT and SRB assays. The results showed significant cytotoxic potential
of examined extracts, with IC50 values ranging from 7 to 138 μg/ml for M.
communis and 3-250 μg/ml for E. camaldulensis. The two plants generally
expressed similar activity, and no significant difference in cell line’s
sensitivity towards extracts was observed. The results indicate to M.
communis and E. camaldulensis as candidates for thorough chemical analyses
for identification of active compounds, and eventually for attention in the
process of discovery of new natural products in the control of cancer.
Keywords: cytotoxicity, MCF 7, MDA-MB-231, Myrtus communis L.
Projekat Ministarstva nauke Republike Srbije, br. 173037 i br. 172058