Vojnosanitetski pregled 2016 Volume 73, Issue 1, Pages: 59-65
https://doi.org/10.2298/VSP140930030R
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Respiratory syncytial virus infection and bronchial hyperreactivity in children up to two years of age in correlation with atopy
Relić Tijana (Public Health Institute of Belgrade, Belgrade, Serbia)
Ilić Nevenka (Public Health Institute of Kragujevac, Kragujevac, Serbia)
Kostić Gordana (Clinical Center Kragujevac, Pediatric Clinic, Kragujevac, Serbia)
Jovanović Dara (Public Health Institute of Belgrade, Belgrade, Serbia)
Tambur Zoran (Military Medical Academy, Institute of Hygiene, Belgrade, Serbia)
Lazarević Ivana (University of Belgrade, Faculty of Medicine, Institute of Microbiology and Immunology, Belgrade, Serbia)
Background/Aim. Bronchiolitis in early childhood caused by respiratory
syncytial virus (RSV) is considered to be important risk factor of the
recurrent wheezing and asthma development. The aim of this study was to
examine the frequency of RSV infection and atopy in children up to two years
of age and to determine their correlation with bronchial hyperreactivity.
Methods. The study included 175 children aged 5-24 months. The presence of
RSV infection was identified by serum levels of IgA and IgG determined by
ELISA. Bronchial hyperreactivity (BHR) has been defined as the existence of
chronic bronchial disease and/or three or more previous suspected diagnosis
of acute bronchial disease. Atopy was confirmed by detection of the specific
serum IgE using quantitative multitest Phadiatop infant (cut off ≥ 0.35
kUA/L). Results. The children with atopy were more frequently infected with
RSV (43.3%) than those without atopy (22.8%; p = 0.02). The higher frequency
of RSV infection was found in children with BHR in comparison with those
without it but only in the group who also had atopy (77.8% vs 28.6%, p =
0.018). In the female children, BHR and RSV infection were associated in
62.5% of cases, regardless the atopy. In the male children with atopy, RSV
infection was associated with BHR in 83.3% of the cases, while in those
without atopy, RSV infection with BHR was found in only 17.4% of the cases.
Conclusion. Children up to two years of age with atopy are more frequently
infected with RSV (43.3%) than non-atopic children. Every third child with
atopy develops BHR and 77.8% of them also have RSV infection. Atopic
children are at higher risk for development of BHR when infected with RSV
also.
Keywords: respiratory syncytial viruses, bronchial diseases, hypersensitivity, immediate, comorbidity, child, Serbia