Journal of the Serbian Chemical Society 2013 Volume 78, Issue 9, Pages: 1269-1289
https://doi.org/10.2298/JSC130402040R
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Polyunsaturated fatty acids in health and disease
Ristić-Medić Danijela (Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, Belgrade)
Vučić Vesna (Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, Belgrade)
Takić Marija (Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, Belgrade)
Karadžić Ivana (Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, Belgrade)
Glibetić Marija (Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, Belgrade)
Polyunsaturated fatty acids (PUFAs) are necessary for overall health. The two
PUFAs families, n-6 and n-3 fatty acid are physiologically and metabolically
distinct. Proportion of PUFAs in serum and erythrocyte phospholipids is an
important determinant of both health and disease, and depends on endogenous
metabolism controlled by genetic polymorphisms and dietary intake. Both n-3
and n-6 PUFAs are processed to powerful promoters of eicosanoids synthesis at
the cyclooxygenase and lipoxygenase level. Evidence from observational and
intervention studies suggest that n-3 PUFAs are cardioprotective, perhaps
through their anti-inflammatory, anti-arrhythmic, lipid-lowering, and
antihypertensive effects. In contrast, dietary n-6 PUFAs have
pro-inflammatory effect. Low n-3 and elevated n-6 PUFAs levels were found in
patients with cancer on different sites. The present review will focus on the
current knowledge related to PUFAs intake and status in health and disease,
with reference to the Serbian population.
Keywords: n-3, n-6, PUFA, inflammation, cardiovascular disease, chronic diseases
Projekat Ministarstva nauke
Republike Srbije, br. III41030