Journal of the Serbian Chemical Society 2013 Volume 78, Issue 2, Pages: 217-227
https://doi.org/10.2298/JSC120725154S
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Synthesis, characterization and cytotoxicity of palladium(II) complex of 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one
Šmit Biljana 
(Faculty of Science, Kragujevac)
Pavlović Radoslav Z. (Faculty of Science, Kragujevac)
Radosavljević-Mihailović Ana (Vinča Institute of Nuclear Sciences, Belgrade)
Došen Anja (Vinča Institute of Nuclear Sciences, Belgrade)
Ćurčić Milena G. (Faculty of Science, Kragujevac)
Šeklić Dragana S. (Faculty of Science, Kragujevac)
Živanović Marko N. (Faculty of Science, Kragujevac)
The polydentate ligand,
3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one, was
synthesized by intermolecular cyclocondensation reaction of
2-hydroxybenzaldehyde thiosemicarbazone and ethylchloroacetate. Novel
palladium(II) complex was obtained by nucleophilic substitution of both DMSO
ligands from cis-[Pd(DMSO)2Cl2] with iminic nitrogen and thiolactamic sulfur
from ligand. The structure of compounds was characterized on the basis of
their spectral data. The cytotoxic activity of the ligand and palladium(II)
complex was studied on tumor cell lines: human colon carcinoma HCT-116 and
SW-480 cells using MTT viability test. The results show that investigated
palladium(II) complex has significantly greater cytotoxic effect compared to
ligand.
Keywords: thiohydantoins, palladium(II) complexes, cytotoxic activity
Projekat Ministarstva nauke Republike SRbije, br. 172011 and
III41010