doiSerbia

Hydantoins: Synthesis, properties and anticonvulsant activity

Trišović Nemanja P. (Tehnološko-metalurški fakultet, Beograd)
Ušćumlić Gordana S. (Tehnološko-metalurški fakultet, Beograd)
Petrović Slobodan D. (Tehnološko-metalurški fakultet, Beograd + Hemofarm koncern, Vršac)

Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

Keywords: hydantoin, properties, reactivity, synthesis, phenytoin, anticonvulsant activity, pharmacofor model, lipophilicity, hydrogen bonding