Chemical Industry and Chemical Engineering Quarterly 2011 Volume 17, Issue 3, Pages: 341-348
https://doi.org/10.2298/CICEQ110407020S
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Stability indicating liquid chromatographic method for the estimation of desvenlafaxine in pharmaceutical dosage form
Shah Dimal A. (Indukaka Ipcowala College of Pharmacy, Beyond GIDC, Gujarat, India)
Nakrani Riddhi S. (A.R. College of Pharmacy, Gujarat, India)
Baldania Sunil L. (A.R. College of Pharmacy, Gujarat, India)
Chhalotiya Usmangani K. (A.R. College of Pharmacy, Gujarat, India)
Bhatt Kashyap K. (A.R. College of Pharmacy, Gujarat, India)
A simple, sensitive, precise and stability indicating liquid chromatographic
method has been developed for the estimation of desvenlafaxine succinate in
pharmaceutical dosage form. A Hypersil C-18, 5 mm column with a mobile phase
containing 0.05 M potassium dihydrogen phosphate: methanol (60:40 v/v) pH 7
was used. The flow rate was 1.0 mL/min and effluents were monitored at 226
nm. The retention time of desvenlafaxine was 7.4 min and the method was
linear in the range of 0.1-20 µg/mL. Desvenlafaxine stock solution was
subjected to acid and alkali hydrolysis, chemical oxidation and dry heat
degradation. The drug was found to be susceptible to base hydrolysis and
developed method was found to give good separation between the pure drug and
the degraded product. The method was successfully applied to the estimation
of desvenlafaxine in tablet dosage forms.
Keywords: desvenlaflaxine, degradation, reversed phase liquid chromatography, validation
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