Archives of Biological Sciences 2012 Volume 64, Issue 3, Pages: 1157-1163
https://doi.org/10.2298/ABS1203157V
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Morphometric characteristics of the neurons of the human subiculum proper
Vulović Maja (Department of Anatomy and Forensic Medicine, Faculty of Medical Sciences, Kragujevac)
Živanović-Mačužić Ivana (Department of Anatomy and Forensic Medicine, Faculty of Medical Sciences, Kragujevac)
Jeremić D. (Department of Anatomy and Forensic Medicine, Faculty of Medical Sciences, Kragujevac)
Stojadinović D. (Department of Anatomy and Forensic Medicine, Faculty of Medical Sciences, Kragujevac)
Tanasković Irena (Department of Histology, Faculty of Medical Sciences, Kragujevac)
Popović-Deušić Smiljka (Institute of Mental Health, Belgrade)
Peljto A. (Institute of Mental Health, Belgrade)
Toševski J. (Department of Anatomy and Forensic Medicine, Faculty of Medical Sciences, Kragujevac)
The human subiculum is a significant part of the hippocampal formation
positioned between the hippocampus proper and the entorhinal and other
cortices. It plays an important role in spatial navigation, memory processing
and control of the response to stress. The aim of our study was
identification of the morphometric characteristics of the neurons of the
human subiculum proper: the maximum length and width of cell body and total
dendritic length and volume of cell body. Comparing the measured parameters
of different types of subicular neurons (bipolar, multipolar, pyramidal
neurons with triangular-shaped soma and neurons with oval-shaped soma), we
can conclude that bipolar neurons have the lowest values of the measured
parameters: the maximum length of their cell body is 14.1 ± 0.2 µm, the
maximum width is 13.9 ± 0.5 µm, and total dendritic length is 14597 ± 3.1 µm.
The lowest volume value was observed in bipolar neurons; the polymorphic
layer is 1152.99 ± 662.69 µm3. The pyramidal neurons of the pyramidal layer
have the highest value for the maximal length of the cell body (44.43 ± 7.94
µm), maximum width (23.64 ± 1.89 µm), total dendritic length (1830 ± 466.3
µm) and volume (11768.65±4004.9 µm3) These characteristics of the pyramidal
neurons indicate their importance, because the axons of these neurons make up
the greatest part of the fornix, along with the axons of neurons of the CA1
hippocampal field.
Keywords: Neurons, human subiculum, hippocampal formation, dendrites, morphometry