doiSerbia

Green one-pot, four-component synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives using amino-functionalized nanoporous silica SBA-15 under solvent-free conditions

Ziarani Ghodsi Mohammadi (Alzahra University, Department of Chemistry, Tehran, Iran)
Rahimifard Mahshid (Alzahra University, Department of Chemistry, Tehran, Iran)
Nouri Fatemeh (Alzahra University, Department of Chemistry, Tehran, Iran)
Badiei Alireza (University of Tehran, College of Science, School of Chemistry, Tehran, Iran)

Propylamine functionalized nanoporous silica (SBA-Pr-NH2) has been used as an efficient heterogeneous solid basic nanoreactor in the synthesis of 6'-amino-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one derivatives 5 through one-pot, four component condensation of isatin derivatives 1, activated methylene reagents 2, hydrazine hydrate 3 and β-keto esters 4 under solvent free conditions at room temperature

Keywords: SBA-Pr-NH2, solvent free, nanoporous silica, four components, one-pot, spiro indole, pyranopyrazole