Journal of the Serbian Chemical Society 2012 Volume 77, Issue 3, Pages: 279-286
https://doi.org/10.2298/JSC110630197S
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Cited by
Design, synthesis and antimicrobial activity of new biquinoline derivatives
Shah Nirav K. (Department of chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India)
Shah Nimesh M. (Department of chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India)
Patel Manish P. (Department of chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India)
Patel Ranjan G. (Department of chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India)
A simple and efficient method has been developed for the synthesis of some
novel biquinoline derivatives bearing a thiazole moiety through a onepot
three-component condensation of 2-chlro-3-formylquinolines, ethyl
cyanoacetate and β-enaminone using catalytic amount of piperidine in
refluxing ethanol. These molecules were evaluated in vitro for their
antibacterial and antifungal activity. Most of the compounds exhibited
moderate antibacterial and antifungal activity against all the tested
strains.
Keywords: quinoline, thiazole, antibacterial, antifungal