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Photostability of piroxicam in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin

Nikolić Vesna D. (Faculty of Technology, Leskovac)
Ilić-Stojanović Snežana S. (Faculty of Technology, Leskovac)
Nikolić Ljubiša B. (Faculty of Technology, Leskovac)
Cakić Milorad D. (Faculty of Technology, Leskovac)
Zdravković Aleksandar S. (Vocational High School for Textiles, Leskovac)
Kapor Agneš J. (Faculty of Sciences, Department of Physics, Novi Sad)
Popsavin Mirjana M. (Faculty of Sciences, Department of Chemistry, Novi Sad)

The aim of this work is the protection of piroxicam from photodegradation by forming inclusion complex with 2-hydroxypropyl-β-cyclodextrin. Piroxicam:2-hydroxypropyl-β-cyclodextrin molecular inclusion complex was prepared by coprecipitation method with molar ratio of 1:1. Structural characterization of the complex, the corresponding physical mixture and complexing agents of piroxicam and 2-hydroxypropyl-β-cyclodextrin was carried out by X-ray diffraction (XRD), proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy (FTIR). Photosensitivity to daylight for piroxicam and piroxicam:2-hydroxypropyl-β-cyclodextrin inclusion complex was investigated by Fourier-transform infrared spectroscopy. The investigations show that higher photostability of piroxicam was achieved in complex than in non-complexed piroxicam.

Keywords: inclusion complex, piroxicam, 2-hydroxypropyl-β-cyclodextrin, photodegradation