Acta chirurgica Iugoslavica 2012 Volume 59, Issue 1, Pages: 31-38
https://doi.org/10.2298/ACI1201031H
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Influence of second or multiple tumours on the prognosis of patients with colorectal cancer
Hildebrand Philipp (Department of Surgery, University of Luebeck Medical School, Luebeck, Germany)
Humke Janina (Department of Surgery, University of Luebeck Medical School, Luebeck, Germany)
Oevermann Elisabeth (Department of Surgery, University of Luebeck Medical School, Luebeck, Germany)
Schloericke Erik (Department of Surgery, University of Luebeck Medical School, Luebeck, Germany)
Bürk Conny (Department of Surgery, University of Luebeck Medical School, Luebeck, Germany)
Roblick Johannes Uwe (Department of Surgery, University of Luebeck Medical School, Luebeck, Germany)
Hans-Peter Bruch (Department of Surgery, University of Luebeck Medical School, Luebeck, Germany)
Czymek Ralf (Department of Surgery, University of Luebeck Medical School, Luebeck, Germany)
Background: Colorectal cancer is one of the most common forms of cancer in
the Western world. A wide variety of prognostic factors for colorectal cancer
have been identified. There is, however, a paucity of literature addressing
the influence of multiple primary carcinomas on prognosis. We conducted the
present study in order to investigate the influence of second or multiple
primary tumours on the prognosis of colorectal cancer patients. Patients and
Methods: From 1992 to 2005, 1500 patients underwent surgery for colorectal
cancer at the University Hospital of Luebeck. Of these, 276 patients (19%)
had multiple primary malignant tumours. We performed statistical analyses
only on patients who underwent surgery with curative intent in order to
minimise additional prognostic factors. The patients were divided into groups
according to the time of multiple primary tumour occurrence. Data were
analyzed for various variables. Results: We did not detect any significant
differences in survival either between the various groups or between patients
with and without multiple primary tumours. Conclusion: The presence of
multiple primary carcinomas is not an independent prognostic factor in
patients with an index tumour of the colorectum. Multiple primary tumours are
thus not necessarily associated with a poorer outcome and patients should
receive curative intent surgery and appropriate follow-up care.
Keywords: colorectal cancer, multiple primary carcinomas, prognostic factor