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T2-weighted combined with diffusion-weighted images for evaluating prostatic transition zone tumors at 3 Tesla

    Jing Ren

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China

    ,
    Yong Yang

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China

    ,
    Jinsong Zhang

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China

    ,
    Jian Xu

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China

    ,
    Ying Liu

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China

    ,
    Mengqi Wei

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China

    ,
    Yali Ge

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China

    ,
    Yi Huan

    * Author for correspondence

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China. .

    ,
    Andrew C Larson

    Department of Radiology, Northwestern University. Chicago, IL 60611, USA

    Robert H Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA

    &
    Zhuoli Zhang

    Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi’an 710032, China

    Department of Radiology, Northwestern University. Chicago, IL 60611, USA

    Robert H Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA

    Published Online:https://doi.org/10.2217/fon.13.14

    Aim: We hypothesize that the combination of T2-weighted (T2W) MRI with diffusion-weighted imaging (DWI) methods provides a powerful clinical application for the differential diagnosis of prostate cancer and benign lesion in the prostatic transition zone (TZ). Methods: This retrospective study included 113 patients who were diagnosed with TZ lesions by MRI. The apparent diffusion coefficient values were compared between biopsy-proven benign and malignant lesions. Results: The apparent diffusion coefficient values for the malignant nodules were significantly lower than those of the benign nodules. The area under the curve values for T2W imaging combined with DWI and T2W imaging alone were 0.991 and 0.884, respectively. Conclusion: T2W combined with DWI provides a powerful tool for noninvasive differentiation between malignant and benign prostatic hyperplasia nodules in the prostatic TZ.

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