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Future perspectives and challenges with CDK4/6 inhibitors in hormone receptor–positive metastatic breast cancer

    Soley Bayraktar

    *Author for correspondence: Tel.: +1 903 781 1580; Fax: +1 715 464 8101;

    E-mail Address: soley.bayraktar@gmail.com

    Department of Medicine, Division of Medical Oncology & Hematology, Mayo Clinic Health System, Eau Claire, WI, USA

    Department of Medicine, Division of Medical Oncology & Hematology, Biruni University School of Medicine, Istanbul, Turkey

    ,
    Sameer Batoo

    Department of Medicine, Division of Medical Oncology & Hematology, Mayo Clinic Health System, Eau Claire, WI, USA

    ,
    Eyad Al-Hattab

    Department of Medicine, Division of Medical Oncology & Hematology, Mayo Clinic Health System, Eau Claire, WI, USA

    ,
    Sandeep Basu

    Department of Medicine, Division of Medical Oncology & Hematology, Mayo Clinic Health System, Eau Claire, WI, USA

    ,
    Scott Okuno

    Department of Medicine, Division of Medical Oncology & Hematology, Mayo Clinic Health System, Eau Claire, WI, USA

    &
    Stefan Glück

    Global Medical Affairs, Early Assets, Celgene Corporation, Summit, NJ, USA

    Published Online:https://doi.org/10.2217/fon-2020-0234

    There are three US FDA–approved CDK4/6 inhibitors: palbociclib, ribociclib and abemaciclib for patients with HR-positive, HER2-negative (HR+/HER2-) metastatic breast cancer (MBC). They are all equally effective, so the question becomes how to choose among these agents and how to sequence them. Other areas with active investigation include identifying predictive biomarkers for the selection of patients whom may benefit more from CDK4/6 inhibitors, deciding whether to continue CDK4/6 inhibitors after disease progression on CDK4/6 inhibitors, creating novel treatment combinations and expanding use beyond HR+/HER2- MBC. Here, we review the current use of and potential next directions for CDK4/6 inhibitors in the treatment of patients with HR+/HER2- MBC.

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