This paper reports the synthesis of an azide-functionalized deoxynucleoside as a precursor for azide-terminated oligonucleotides. Also reported is the synthesis of an acetylene-terminated precursor, which can be used to make a diverse array of silyl-protected acetylene-terminated small molecule cores. Both of these precursors serve as basic building blocks en route to stable “click”-based small-molecule DNA hybrids.

Last modified

• 07/19/2018

Creator

• Emily Mirkin

DOI

• https://doi.org/10.21985/N2F71B

Keyword

• Volume 5

Date created

• 2008

Resource type

• Article

Rights statement

• In Copyright