Why do Patients Forget to Take Immunosuppression Medications and Miss Appointments: Can a Mobile Phone App Help?

Background: Kidney transplant recipients must adhere to their immunosuppressive medication regimen. However, non-adherence remains a major problem. Objective: The aim of this paper is to determine how kidney transplant recipients remember to take their medications, and assess their perception and beliefs about adherence to immunosuppressive medications and barriers to medication adherence. In addition, we aim to assess perception and beliefs about willingness to use a hypothetical, mobile phone app to improve adherence. Methods: We conducted a qualitative study that included an average of three home or workplace visits of kidney transplant recipients (N=16) from a single urban transplant center. Results: The qualitative study revealed that transplant recipients understood the importance of taking their immunosuppressive medications and this motivated them to take their medications. The visits showed that most participants have incorporated medication use into their daily lives and that any minor deviation from daily routines could result in non-adherence. Participants also reported other barriers to adherence. All participants were interested in using an app to remind them to take their medication; however, they reported potential barriers to using the app. Conclusions: Although kidney transplant recipients understood the importance of medication adherence, there were significant barriers to maintaining adherence. Participants also reported interest in using a mobile phone app. (JMIR Public

A novel approach to improving adherence is the utilization of mobile phone medication adherence apps and the use of text messaging (short message service, SMS). A national study by the Pew Research Center reported that 90% of all American adults own a mobile phone, 58% own a mobile phone with app capabilities, and 42% own a tablet computer [13]. The use of mobile phones is increasing among kidney transplant recipients, especially among African Americans and those with lower household incomes [14]. This technology has shown promising results of improved medication adherence in the areas of HIV, tuberculosis, diabetes mellitus, asthma, and emergency department-prescribed antibiotics [15][16][17][18][19][20]. Adherence apps linked to an electronic medication tray and a wireless Bluetooth-enabled blood pressure monitor has been tested in kidney transplant recipients [14,21]. To the best of our knowledge, no other adherence apps tailored to kidney transplantation have been tested.
In order to understand kidney transplant recipients' perceptions and beliefs regarding barriers to medication adherence and potential use of a mobile device platform (presented as paper mock-ups) to improve adherence, we conducted one-on-one semi-structured interviews and home or workplace visits among kidney transplant recipients.

Participants
Transplant recipients were enrolled from August to December 2012 at Hennepin County Medical Center (HCMC). The purposeful sample of ethnically diverse transplant recipients was enrolled based on the perceptions of nurse coordinators that the subjects were either highly adherent or poorly adherent to immunosuppressive medications. Inclusion criteria included the ability to communicate in English, and residence in the Twin Cities area and surrounding suburbs in order to improve feasibility of conducting the interviews. At HCMC, among the 226 recipients transplanted from 2010-2012, 18.1% (41/226) were African American and 3.1% (7/226) were Hispanic. The transplant center actively follows approximately 800 recipients with a kidney transplant. The post-transplant care at the transplant center is routinely managed by a nephrologist. All transplant recipients are seen by a transplant pharmacist at a minimum interval of 2 weeks, 4 weeks, 3 months, 6 months, 12 months, 18 months, and 24 months post-transplant, and yearly thereafter.
All participants were invited for one-on-one semi-structured interviews and home or workplace visits. Initially, twenty participants were enrolled. Four participants dropped out for various reasons such as depression, living with boyfriend, construction at home or traveling. The data on these participants are not included. Each participant gave informed consent and the study was approved by the Human Subjects Research Committee at HCMC.

Procedures
Guides for the semi-structured interviews and home or workplace visits were developed with input from the study investigators. The questions used in the guide, which include closed and open-ended questions, are shown in Textbox 1.
The interviews and visits were conducted by the same individual (BK) who was coached on anthropologic approaches by CJW and/or AI before and weekly during the study. Key findings were discussed with other investigators (CJW, AI) in weekly to bi-weekly meetings for reflection. No clinic or medical personnel were present during these encounters to ensure solid rapport and full disclosure by study participants. The study design included individual interviews for several reasons such as (1) the interviews were conducted during several home or workplace visits; (2) they increased the interviewer's familiarity with study participants' perceptions and beliefs; and (3) they improved trust-building efforts to elicit sensitive data about adherence to medications and appointments during home or workplace visits.
The semi-structured interview methodology was informed by inductive reasoning. While quantitative studies use statistics to establish reliability and validity, qualitative research relies on trust and rapport-building. The semi-structured interviews require the skill of keeping participants on task, maintaining rapport with all to ensure equitable but not peer-pressured participation, and maintaining a high degree of comfort discussing sensitive topics [22]. All interviews were audio taped and reviewed by two authors (BK, AI). The later portion of the semi-structured interview consisted of an oral survey to collect demographic and transplant-related information. The participants' electronic medical records were reviewed for other medical information.

Data Analysis
Qualitative data was collected and analyzed according to the principles of grounded theory. Coding is an iterative process produced through several discussions by researchers to establish broad codes and then further refine the code.
The digital audio tapes of the interviews were transcribed verbatim and visit notes were transcribed to produce 124 pages of text. Coding was done manually without the use of specialized coding software. Two authors (BK, AI) reviewed the transcripts manually, line-by-line to generate a preliminary coding scheme through consensus: a list of codes and corresponding definitions. Therefore, no formal measure of agreement was generated for the codes generated by the two authors. The codes were ordered by thematic similarity or relationship into a project codebook. The resulting themes reflected ideas that emerged over a variety of areas of inquiry by the research team. Quotations that most closely represented the theme were then selected to support the analysis. The data from the transcripts was supplemented with notes taken during home or workplace visits.

Results
The characteristics of the study participants are shown in Table  1. All subjects were interviewed at their residence; however one subject was interviewed at his place of work and one at a coffee shop near her place of residence. The average of 3 visits per participant showed that most participants have incorporated medication use into their daily lives, such as one participant keeping morning medications by the car keys in order to remember to take the medications before leaving for work in the morning. However, any minor deviation from daily routines may result in non-adherence. With one exception, no participants had used electronic reminders on a phone (not a mobile phone) to alert them to take their medications. The one subject that did use reminders utilized the alarm feature on his mobile phone and would not turn off the alarm until he took his medications. None of the participants had mobile phones with app capabilities.
With one exception, all participants used pill boxes due to the large number of medications required. Some subjects also had a smaller pill holder, such as a plastic bag, to carry a single dose of medications. Having this smaller pill holder sometimes resulted in missed medications as some subjects forgot to put medications in this smaller pill holder or forgot to ingest the medications due to deviations from their daily routines. Seven families of codes or themes were identified and yielded 133 non-discrete quotations. These seven main themes structure the rest of this paper.

Motivated to Take Immunosuppression Medication
Study participants demonstrated a clear understanding of the negative consequences of not taking their immunosuppressive medications (Theme 1, Table 2). They mentioned that non-adherence could increase their risk of rejection and increase risk of returning to dialysis. Taking the medications reassured them they would not experience rejection.
A participant described his motivation for taking his immunosuppression medications: "So I don't have to go back on dialysis." Participants dreaded the return to dialysis. One participant remarked: "...I want this kidney to work. I don't like the alternative (dialysis)."

Participants' Perceived Barriers to Taking Immunosuppression Medications
The participants reported barriers to adherence such as forgetting to take or renew medications, procrastination, being short on money, having depression, distractions, change in daily routine, forgetting medications while away from home, alcohol use, and falling asleep before taking evening dose (Theme 2, Table 3) "I thought that I took it that morning, but then later on in the afternoon when I look at the medication package I found out it was not taken." Some patients found it difficult to maintain compliance while traveling: Other participants admitted to simply overlooking their medications "…I just had forgotten to renew them…"

Reported Factors That Helped Participants to Take Their Immunosuppression Medications
Factors that help patients remember to take their immunosuppressive medications include creating a routine around taking their medications, monitoring their medication supplies regularly, using a travel-sized pill holder, having a support system, making medications a top priority, taking medications earlier in the day and trusting their physician (Theme 3, Table 4). Surprisingly, only one participant set an alarm.

Motivated to Keep Appointments
The study participants were motivated to keep their appointments. They referenced their appointments as a way to stay alive and healthy and to monitor their kidney function (Theme 4, Table 5).
Well I choose to go to my appointments so we can monitor the kidney function. Make sure all my levels are where they need to be.
Another participant cited similar curiosity to their health status as a reason to keep appointments:

Participants' Perceived Barriers and Motivation to Keeping Appointments
The study participants reported some barriers to keeping appointments such as transportation, busy schedule, forgetting, not feeling ill or due to personal sickness or sickness in the family (Theme 6, Table 6).

My schedule. I mean I have to do a lot of working around my schedule and then sometimes the clinic is not (open), I think the clinic needs to have extended hours because it just makes it hard
Some patients found it difficult to maintain appointments when they were not feeling well:

Reported Factors That Helped Participants to Keep Appointments
The participants reported scheduling recurrent visits on the same day of the week, various types of reminders and support from others as strategies to keep appointments (Theme 6, Table 7). "When they first started it (the appointment) was Monday, Wednesday, Friday, Monday, Wednesday, Friday then it went down to just Wednesdays, and now I'm going to (every) two weeks so it's every other Monday." Some participants utilized electronic medical record patient communication tools to maintain appointments: I have MyChart and I get emails…'You have so and so many appointments,' and I'll click them and then oh yeah that's a reminder.

Perceived Barriers to a Medication Adherence App
The participants voiced concern regarding their mobile phone being turned off or inaccessible, missing the alarm, and inflexibility of the app to adjust to irregular schedules (Theme 7, Table 8).
If I was in a job interview I would have my phone possibly off or on vibrate…in a meeting it is just common courtesy to do that (turn off phone)…Anywhere from one hour to all day. But there are frequent breaks and during that time everyone checks their phones.
Other participants expressed concern about ignoring their phone during the day: "…when you are pretty busy or when you are enjoying sometimes you don't look at the phone." Because it was prescribed by the doctor 108 "I take it (medication) because it helps me to continue to live to see another day, and also keeps me from going into the hospital…If I don't take it I'm only hurting myself." To stay alive 106 "I don't want to have my kidney reject." To prevent rejection 108 "It's amazing what missing your medications can do to you, and my father is a good example of that. He (my father) might have been able to prevent that stroke had he taken his medications that morning. He felt good, he felt like he was not in a lot of danger." To be adherent because of a death in the family due to nonadherent behavior Forgetting to bring meds to work and work schedule is inflexible 113 "Well so I take so many pills like in the morning I think there are fifteen or sixteen and at a point you get so tired of taking them and you say or you think 'I'll take them a little later'. Then you get to doing things and then something else comes up and then you don't." Procrastinating at taking meds 115 "I procrastinate about ordering my meds. Fairview (pharmacy) will call me and then I'm busy doing something else or in the car or something where they say can you look at your meds now and I say no I can't if I'm driving around." Procrastinating at ordering meds 116 "If you are feeling very good and enjoying things then you forget you are sick. Easy to miss it…" Patients cannot feel the harm they are inflicting on their kidney 113 "I had run out (of money) in the middle of pay days. Even now I try to schedule it, like my wife gets payday Friday and then she and I both get our retirement on the first of the month…I have missed my immunosuppression meds for a day. There was another pill, it was really expensive." Due to being short on money 113 "There was a time when I'm sure I was depressed…It was a duration (of non-adherence) probably of two days max I'm thinking…You just get that lethargic feeling, 'I'm sick of these pills,'…You take them late but you try not to miss them completely." Due to being depressed 101 "About one or two times it was delayed because of the…mail…I was called by the clinic, 'We are sorry we will be late because they were not picked up but by tomorrow it will be around,' and surely I receive it in that time. I ran out of it but I got it the day or two after.'" Pharmacy did not supply meds on time 106 "It was a night, I've never forgotten to take the morning pills, it's always been the night pills…I will sometimes get caught up in doing something else and my short term memory can sometimes be bad so sometimes. If I know I don't have to take this until 10:00 o'clock I get busy doing something and then before I know it it's the next morning." Patient forgot to take it due to a distraction 110 "I think maybe one time because I was enjoying myself too much. And I was like I don't think I should be taking my pills after just consuming alcohol. So I just didn't take it. Yeah I was out partying and enjoying myself too much.
Patient didn't want to take meds with alcohol 119 "No, well not deliberately anyway. I just had forgotten to renew them…" Patient forgot to renew his/her prescription 106 "They (pharmacy) have just had issues with the exact company (insurance) that I need to use mainly because the companies (insurance) don't understand how to use Medicare as a secondary insurer… So there has just been an issue mainly with finding a place that will bill Medicare. That is the issue….I would be on the phone with the insurance company and I would beg, and I would say, 'I will get sick without them'…It was just kind of a mess. It was mainly on the administrative side." Patient changed pharmacies (due to insurance coverage) 119 "The one time I was living in the other place I was living in, they delivered them and left them at the door because it's a safe neighborhood and they weren't there when I got home from work…They said they delivered them, they traced it to the door and one of my roommates…so now I get them delivered to me at work and everyone leaves them alone when I'm not there." Medications were stolen 107 "I was late. It was just the first time I was off my schedule…I was at somebody else's house and we were talking at a dinner party or something…" Patient forgot to take their meds when they were out of their house 119 "Oh yeah, like I said before I had forgotten once or twice in the evening. Usually it's the evening dose. It's only a couple of pills and I fall asleep and then oops, ya know. And it's not like I deliberately don't take them." Patient fell asleep and missed PM meds 110 "The morning of the Prograf (trough level) draws, you can't take your Prograf so after the appointment you have to remember to take Prograf because I didn't take it with my other pills. So one particular day I was…distracted so when I left the clinic I was not thinking and then four or five o'clock came and I took my pill box out of my purse and said, 'What are those two Prograf still doing there, oh shoot I didn't take it.'" Taking meds at different time than usual because the patient has their trough levels checked in the lab Table 4. Helps patients to take immunosuppression medications (coded 23 times).

Study identification number
Supportive quotations from patients Authors' interpretation of interviews 100 "Because you might be doing something, you might be driving and then if you turn it off once you stop driving you forget so I don't turn it off until I take the meds…It snoozes automatically for five minutes." Everyday bi-daily alarms 108 "I have a system and…my system it's (medications) the last thing I do before I walk out the door. And the way I know I have to take my medication is because it's by my keys. Keys to drive the car, keys to lock the door, keys to get into my office. So when I get up and do all these things that I need to do to get prepared to go out, the last thing I see is my medication by my keys…I have ten tubes of medications. I load all those up at the start of the week." Taking pills around the same time and creating a routine 101 "Every weekend I check my medication. Because I do the packing in the separate (pillboxes). So when I find out this is getting short…I call them and tell them those medications that I need and she told me in a day or two they will be here." Patient monitors med supplies regularly 100 "So if I'm going to go somewhere and I know I will be gone, I got a little pill box, so I pop them out and put them in a pill box. So say I'm at Bible study and we don't get out until 9:30 and I take my meds at 9:00. My alarm will go off, pop them pills." Taking medications at times that are easy to remember 114 "I trust the doctors a little bit too much to be doing that (not taking medications)." Patient trusts their doctor Table 5. Primary motivation to keep appointments (coded 16 times).

Study identification number Supportive quotations from patients Authors' interpretation of interviews
116 "Because when my hemoglobin is very low then I feel very weak and quick tired. Sometimes when I go (to the clinic) the nurse is like, 'Only seven percent of blood is there.' It's very low." To stay healthy 105 "…and I appreciate that about them because they are so vigilant. So I wouldn't not go to them." The patient likes and believes in her doctors care Table 6. Perceived barriers to keeping appointments (coded 13 times).

Study identification number
Supportive quotations from patients Authors' interpretation of interviews 106 "…I don't really have anyone to watch my kids so I may have to bring them with me which I've never done and I don't really want to do that because it's very distracting and hard to do with two of them." Being distracted by kids 101 "… Mostly I contact the transport company then sometime (they are) a little bit late. Sometime (they are) very early that I have to go and wait for almost one hour before I can see my doctor. Sometime they are late that when I reach there the doctor and nurses say we will consider seeing you but you are late." Not having transportation 114 "It's usually been a scheduling conflict…I would schedule a lab appointment down here and something at (hospital) at the same time." Due to double booking doctors' appointments 119 "Nothing (gets in the way of my appointments) unless I'm really sick with the flu or something." Sickness 106 "I guess if it's (the reminder) too far in advance then it's not really that meaningful for the same reason I sometime forget to take (my medications), if it's too far in advance it's not really that immediate. I'm really more in the moment." Reminder too far in advance 113 "Once I missed and it was just that I overslept." Oversleeping 119 "…I did (forget), but I thought it was the following week. I think we got our dates switched…" Forgot the appointment Table 7. Helps patients to keep appointments (coded 22 times).

Study identification number
Supportive quotations from patients Authors' interpretation of interviews 115 "Just mainly towards the end of the month so I remember that it's getting towards the end of the month so I should see when the next lab is." Visits scheduled on the same day of the week or month 117 "The card...I put it in my wallet in the front." Patient puts transplant clinic appointment card in his/her wallet 108 "Well it gives me a chance to get to know I'm on someone's mind as far as the clinic. I get a chance to hear a nurse's voice on the phone and kid around with them on the phone. So receiving that call does a lot. It shows that they're on their job making sure that patients don't forget their appointment. And you kind of build a little rapport with them on the phone. And I kind of look forward to those calls." Phone call reminder from the doctor's office 102 "…I have to go in (to a clinic appointment) on Friday and I've already emailed my boss saying that I will be working from home because I have a doctor's appointment." Work is accommodating and flexible 102 "…I make this a top priority. This is a very important priority that we keep in the back of our minds at all time. My meds come first. Doctors' appointments are first." Making appointments is a top priority 106 "…I will write myself a note to remember. For example, 'I actually have to schedule one for December, but I know it is important enough that I actually have to write myself a note to remember because if I wait until December, chances are they just get really busy, so I need to call in advance." Patient has written personal reminders 114 "Yup, and that way it's easier to remember because it's (email) in writing. Then I can always go back on MyChart and say, 'Hey that's what they said,' so I can always remember." Email doctor through MyChart 108 "…my medical appointments I have set up for both a day and a half an hour before I'm supposed to go. So I get a one day alarm and I get a thirty-minute alarm. But once I get that one day alarm, it's already in my mind that I have to go tomorrow. Then I have thirty minutes, okay time to get ready to go." Mobile phone calendar reminders for appointments 119 "Yeah, I usually have it set for forty-five minutes before hand so I have time to get there and stuff." (BL) "And is the same thing for lab appointments?" "Yeah, mmhmm." Mobile phone calendar reminders for appointments Table 8. Future perceived barriers to the app (coded 9 times).

Study identification number
Supportive quotations from patients Authors' interpretation of interviews 106 "I will turn it on silent at night, but I don't shut it off." Phone turned off periodically 110 "Well like for Prograf (trough levels)…they call you the day before and remind you to take your Prograf at a certain time. And just because I've been doing it for over a year it's like I know that I have to take it. Even though it is good sometimes because I have (forgotten)." App alarms, though helpful, may become too annoying so the patient turns them off 113 "Straight reminder that's maybe after a while going to be a nuisance if you get the re-minder….after you've already taken them and then you get something that says, 'Take your meds!'" 112 "I have a little spot on the counter and so it's plugged in there right now and if I were to go out and do something in the garage it wouldn't be with me. My son comes home and we go out and play, it's not with me." People not having their mobile phone on them all the time 114 "So like I said send me a message before I go…If I work tomorrow at 6:00 then an automated (message) at 5:30 saying do you have your medications ready for work or something." If the app is not flexible enough to work with irregular schedules 117 "That's…easy to forget to take the picture. And then they are going to think that I don't take my medication..." It may cumbersome to take a mobile phone picture to document medication ingestion to prevent the app alarm. (This option for the app was posed to the participants)

Principal Findings
The kidney transplant recipients that participated in these interviews demonstrated an understanding of the importance of immunosuppression medications. Commonly cited reasons to remain compliant included to avoid dialysis, stay alive, prevent rejection, and witnessed complications from noncompliance in family members (Table 2). Despite these appropriate concerns, participants shared numerous perceived barriers to maintain perfect adherence to immunosuppression medications. These barriers included simply forgetting to take or renew medications, procrastinating, being short on money, having depression, getting distracted, change in daily routine, forgetting medications while away from home, alcohol use, and falling asleep before taking evening dose (Table 2).
We found it reassuring that our participants identified understanding the importance of immunosuppression medication. In a previous publication using mailed surveys, Chisholm-Burns et al identified that kidney transplant recipients were more likely to miss doses of medications when they acknowledged a weaker belief on the necessity of maintenance immunosuppression medications [23]. Our results suggest that among the participants in our study, present efforts to educate kidney transplant recipients on the importance of immunosuppression are successful to a large extent and should be continued [24,25].
Similar to our findings, several previous investigations have reported patient-identified barriers to medication compliance. Consistent with our findings, these publications have cited limited financial resources, and forgetfulness, interruption of daily routine, travel or leaving home, change in dose, run out of medications, and no immediate access to a pharmacy as barriers to compliance [23,[25][26][27]. Intentional non-adherence has been found previously to be significantly lower than unintentional non-adherence among kidney transplant recipients [26,28]. We found a similar trend among responses in our study. This suggests that larger improvements in adherence may be seen with strategies designed to remind patients to take medications and facilitate delivery and administration of medications in addition to education them on their importance. The behavioral change theories commonly used in mobile app applications, such as health belief model (perceived susceptibility, perceived severity, perceived benefits, perceived barriers, cues to action, and self efficacy), and social cognitive theory (self efficacy, expectations, behavioral capability, observational learning, reinforcements, and reciprocal determinism), combined with behavioral techniques such as nudges (eg, loss aversion, anchoring, and benchmarking), can facilitate medication adherence [29][30][31].
Interestingly, when we tested the idea of using a paper mock-up of a mobile phone app specifically designed for kidney transplant recipients we receive generally positive responses. While some participants reported interest in this utility, others raised concerns with this proposal such as what would happen when the phone was switched off or not in their immediate proximity, developing annoyance to a phone alarm, and the inflexibility of the app to adjust to chaotic and changing schedules were concerns raised by participants (Table 8). A recent review of mobile phone medication adherence apps identified 160 currently on the market. While their efficacy remains untested, medication adherence apps offer many potential benefits that include constant accessibility, ease of use, low cost, and ability to consolidate all medication-specific information for the patient and provider. Based on their respective capabilities and ease of use, the review distinguished ten medication apps as noteworthy. These apps are MyMedSchedule, MyMeds, MedSimple, Med Agenda, RxmindMe Prescription, Dosecast, TRxC (Beta) MediMemory, PillManager, and MedsIQ Individual/Multi-user. No free-standing app, however, was specifically tailored to kidney transplant recipients [32].
In response to the concerns identified by participants in this study, it is our belief that a mobile phone app designed for kidney transplant recipients would have the following features. First, it would be easy to input a multi-drug regimen into the app. Second, the app would offer a choice of options for notification of medication due time. These options would include a standard text message, an email generation or alarm feature when a medication would be due. Third, the app could generate a reminder of a due medication without cellular connectivity. Fourth, the app would feature a "snooze" button to allow for an additional reminder to take the medication if the user was unable to complete the task immediately. Fifth, instead of just a simple reminder, the app would have a feature that allow the user to voluntarily indicate if they did or did not take the medication and note the time when this occurred. This data could be collated and downloaded at the physician office as a way to prompt discussion between the caregivers and the patient of methods to improve adherence. Sixth, the app could communicate with the patient's primary pharmacy and facilitate refills as they become necessary to prevent lapses in medication availability. Finally, any app created based on this input would have to be tested extensively among transplant patients to ensure the app engages the patients through social competition [33], and individual encouragement [34]. Previous focus groups have shown that peer-support relationships and talking to other patients on dialysis therapy have motivated transplant recipients [33].
To our knowledge, no studies utilizing mobile phone apps to improve outcomes in kidney transplant recipients have been published. One study of pediatric liver transplant recipients showed significant reduction in variation of tacrolimus levels using text messaging reminders and suggests that adopting this reminder system may lead to improved medication adherence and decreased episodes of rejection [35].

Limitations
There are several limitations in the current study. First, although we had a diverse group of participants based on their socio-economic information, this study was conducted with a small sample size of prevalent patients in a single center study. In addition, common themes were appearing in the qualitative data provided by the participants. Second, four patients with unstable living situations or depression dropped out of the study; thus, it is possible we may have missed some issues specific to vulnerable populations. We did not include patients that lost their allograft due to noncompliance. However, our findings are generally consistent with previous survey responses regarding the reported barriers to medication adherence from other transplant centers [23,[25][26][27]. None of our subjects had mobile phones, despite no purposeful sampling in regards to access to mobile phone was used. The mobile phone use in 2012 at our county hospital was likely low. Lastly, we did not measure adherence in our study participants; thus, the barriers and facilitators to adherence may be participants' perceptions.
From this qualitative study of medication adherence practices, it is clear that patients have incorporated medications into their daily lives and schedules, but that any variation to this schedule increases the risk of noncompliance. In addition, there are numerous barriers to medication adherence that participants in our studied identified, and participants utilized a variety of techniques to reduce the influence of these barriers. While no transplant-specific app exists presently, an app tailored to the needs of a busy transplant recipient may improve medication adherence.